DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment side-VI and syg-2

DIOPT Version :9

Sequence 1:	NP_001036705.1	Gene:	side-VI / 4379854	FlyBaseID:	FBgn0083950	Length:	1087	Species:	Drosophila melanogaster
Sequence 2:	NP_001309674.1	Gene:	syg-2 / 181561	WormBaseID:	WBGene00007750	Length:	1230	Species:	Caenorhabditis elegans

Alignment Length:	904	Identity:	189/904 - (20%)
Similarity:	309/904 - (34%)	Gaps:	248/904 - (27%)

- Green bases have known domain annotations that are detailed below.

  Fly     8 LICLIMGAITHANSHEHADGFKPDGEILRVLVNSSAQIKCDVGSSQADDKVLLVVWYKNNLPIYS 72
            ::..:.|:|     |..:..|......|..:...|...:|  .:.::.:.::...|..|...:..
Worm     6 ILLWLFGSI-----HISSQFFLESPSNLSTIAGESITFRC--SAEKSPEPIVYSQWKSNTGSLLG 63

  Fly    73 YDTRG---AHAGTPSHWRDEEVLEDRAVFRTHKEPAELIINPVKEKDAGNFRCRVDFKLSQTRNS 134
            |...|   .|.|..|:            .:.:.|...|.|..|...|.|.:.|::.........:
Worm    64 YHQEGILPGHQGRFSY------------IKQNAEELHLKITHVNLDDDGEYECQMLHPEEGPIRA 116

  Fly   135 NVNLEVVVPPTQPIIFNERRLRIDSRAGPYEEGGSLEVTCVVYGGSPPPTVIWLMNGQLQNSVVD 199
            ...|.::||| |.:.|:..:   .:.....:|...|.:||||....|.|.|:|.|:|::.:..|.
Worm   117 KSFLNIIVPP-QLVYFSNYQ---PNSIIAVKENTPLNITCVVPNVKPEPEVLWYMDGKVMSRDVK 177

  Fly   200 YTYDGAIN------SKLVVRNLSRIHQHAVYTCQASNFHKK---YVATNITIDLYLRPL--LVEI 253
            ......:|      :.|||:: .|.....|.||:|  |.|:   .:.||.|:|:...|.  .|||
Worm   178 QASTPHLNKTFTVYTSLVVQS-DRNDHGKVITCEA--FQKETDIRITTNTTLDVLFPPSDPTVEI 239

  Fly   254 SFNNQPMSADRKYEIECQAIGSRPPAKITWWMGNLELHGHSQKVSEDGNVSTSVLSITPTREDHG 318
            ..|...:.:.....|.|...|..||..:.|:..|..|..||...:....:. ::.|...::.|:.
Worm   240 LRNPSALRSGDNVTIACSVTGGNPPPDVFWYHENKRLQSHSTLDTRSKEIK-NIYSFIASQNDNM 303

  Fly   319 KALSCRATNELVRNGIRETAMKLNVFFIPTLQLDLGSNLNPEDIEEGDDVYFECK-VHANPAAYK 382
            ....|||.|....|..|: ||||.|.: |...::|....|   |..|.....:|| :.:|||: :
Worm   304 AEYECRANNSRTGNPKRK-AMKLEVNY-PPASVELFGESN---IRYGSSANIQCKSLPSNPAS-Q 362

  Fly   383 VVWKHN-HQIIQHNQRAGV----IVSSGDLALQ----GVTRHQAGNYTCTASNVEGDG------- 431
            :.|..| ..:....||..|    ||||.::::.    .|..||. |..|.|:|.||..
Worm   363 ITWIINGRSVPTPTQREFVVENGIVSSSNVSVHSNELSVEAHQI-NVECMATNPEGSSAKQHVIK 426

  Fly   432 ----------------------------------------------------------------- 431

Worm   427 IIAPPKAPIITGLEDRKFFEGDIVNVTCEAQGGNPLAELSWYRGSEKHLVKGRKKMKWSQVNGAH 491

  Fly   432 ----------------------------------DSNVVE---LKVMYKP---ICRP----DQKK 452
                                              |..::|   |.|.|.|   :.||    ||:.
Worm   492 NEVAGFSSYSTLALRVDRTMNTQRLKCEATNAALDEPLIESQYLSVYYPPRRVLIRPADSGDQRL 556

  Fly   453 IYGVARNEAAEIVCEVDAFPPPENFKWSF-----NNTAETFDMP------QSGFRPHSAQGSTLT 506
            :.|    ::|.:||...:..|..:..|.|     :|.....|:.      .:||...    :.|:
Worm   557 LVG----KSARLVCGTLSSNPAAHISWQFSRATDDNKVHLGDVSLNETTRDNGFNVE----NVLS 613

  Fly   507 YTPVKEMDFGTIMCWADNNVGQQKEPCVFHLIAAGKPEAPTN--CTVVNQTSDSL-EVYCIEGFD 568
            :||.:|.|...:.|.|::...:......|.|.....|:...|  .|||....||. |...:.|..
Worm   614 FTPTEEYDGTVVHCIANHPEWKHSVNTSFPLNVMYPPKMLVNDPVTVVMSEGDSFKENLTVRGNP 678

  Fly   569 G-GMRQWFLMEI-FDQHSGQLQANISAKFAALS---VTGLDAGRLFRIYVYAVNGRGRSDAIALD 628
            . .:.||....: ||...|:    :.|:.|.||   :...|||      ||.:..   ::::...
Worm   679 AISLWQWRKNGVPFDHTIGR----VFARGAVLSGKQLLSTDAG------VYTLTA---TNSVGST 730

  Fly   629 GYTLKAAEKQTVALTSYKGSAQSPDNFELTPILSIGIFVGILVAIVC--------------IGIG 679
            ..|:|.|.:.:..:||..           ||:::.   .|..|.:.|              ...|
Worm   731 NITIKLAVEYSARITSIS-----------TPVIAA---TGDTVLLECEADGEPSKANMIHWYKNG 781

  Fly   680 TIAALKLRSHKHQQQQKFVHPNAKFSRPGNLQIK--DKISLPLSHSEEMYDEKNPDVVP 736
            .|.|.:.|.||    :..:..||...:.|....|  :.|.:|......:.....|.|:|
Worm   782 EILAAQHRGHK----KAILRLNATEQQSGEYTCKADNGIGVPAEGQTFLLVNSAPRVLP 836

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
side-VI	NP_001036705.1	IG_like	35..140	CDD:214653	18/107 (17%)
		Ig_3	157..230	CDD:290638	22/78 (28%)
		IG_like	165..242	CDD:214653	26/85 (31%)
		Ig	265..343	CDD:299845	22/77 (29%)
		IG_like	267..343	CDD:214653	22/75 (29%)
		IG_like	363..440	CDD:214653	27/195 (14%)
		IGc2	364..429	CDD:197706	22/74 (30%)
		IG_like	456..532	CDD:214653	17/86 (20%)
		Ig_3	456..524	CDD:290638	17/78 (22%)
		fn3	545..622	CDD:278470	22/84 (26%)
syg-2	NP_001309674.1	IG_like	25..105	CDD:214653	16/93 (17%)
		Ig	33..122	CDD:299845	17/102 (17%)
		Ig	147..228	CDD:299845	26/83 (31%)
		IGc2	248..313	CDD:197706	15/65 (23%)
		Ig	450..537	CDD:299845	3/86 (3%)
		Ig	559..632	CDD:299845	18/80 (23%)
		I-set	657..738	CDD:254352	23/93 (25%)
		Ig	665..738	CDD:299845	20/85 (24%)
		IG_like	748..828	CDD:214653	17/97 (18%)
		IGc2	756..817	CDD:197706	13/64 (20%)
		Ig	845..922	CDD:299845
		FN3	934..1023	CDD:238020
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3515
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.810