DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment side-VI and igcm-1

DIOPT Version :9

Sequence 1:	NP_001036705.1	Gene:	side-VI / 4379854	FlyBaseID:	FBgn0083950	Length:	1087	Species:	Drosophila melanogaster
Sequence 2:	NP_508166.1	Gene:	igcm-1 / 180433	WormBaseID:	WBGene00018215	Length:	1073	Species:	Caenorhabditis elegans

Alignment Length:	858	Identity:	187/858 - (21%)
Similarity:	311/858 - (36%)	Gaps:	251/858 - (29%)

- Green bases have known domain annotations that are detailed below.

  Fly     6 PILICLIMGAITHANSHEHADGFKPDGEILRVLVNSSAQIKCDVGSSQADDKVLLVVWYKNNLPI 70
            |::.......:||.:..|        ||::.:..||:                       :|.|.
Worm   246 PVVFVTPTENLTHLSVEE--------GELVNLTCNSA-----------------------SNPPA 279

  Fly    71 YSYDTRGAHAGTPSHWRDEEVLEDRAVFRTHKEPAELIINPVK--EKDAGNFRCRVDFKLSQTRN 133
            :||:.:  |..:...::.:                   |.|::  ...:|:|.||...:|.:
Worm   280 HSYEWK--HIASGERYQGK-------------------IWPIRVDSSMSGDFECRSTNELGE--- 320

  Fly   134 SNVNLEVVVPPTQPIIFNERRLRIDSRAGPYEEGGSLEVTCVVYGGSPPPTVI---WL-MNGQLQ 194
            ....|::||   |.|    .|:.:.....| .|...:::.|.|   |..|.||   |: .||..|
Worm   321 GTAVLKMVV---QHI----PRINVPESISP-NEMEDIDILCEV---SAVPEVIDIKWVGPNGFKQ 374

  Fly   195 NSVVDYTYDGAINSKLVVRNLSRIHQHAVYTCQASNFHKKY--------VATNITI-DLYLRPLL 250
            |           .|:|.:.::|:. |...|||.|:||...|        :.|..|| |:..:|..
Worm   375 N-----------GSRLTITSISKA-QSGNYTCMATNFLTVYGHSGSQQRMGTGTTIVDVKRKPGQ 427

  Fly   251 VEISFNNQPMSADRKYEIECQA-IGSRPPAKITWWM----GNLELHGHSQKVSEDGNVSTSVLSI 310
            .:|....|.:......::.||| ....|.|..||..    |...|.||::|..|..|...|
Worm   428 AQIVSARQNVDVGETIKLMCQAEDAGNPSASYTWASPSSGGIFGLEGHTEKSFEVRNAQLS---- 488

  Fly   311 TPTREDHGKALSCRATNELVRNGIRETAMKLNVFFIPTLQ-LDLGSNLNPEDI----EEGDDVYF 370
                 |:| ..||:|.|:|...       |:....|..:: ..:.|.|..|.|    |:|.  ..
Worm   489 -----DNG-VYSCKAYNDLGEG-------KIGTVMITVIEKARISSPLATERIFTSGEQGK--IL 538

  Fly   371 ECKVHANPAAYKVVWKHNHQIIQHNQRAGVIVS--------------SGDLALQGVTR-HQAGNY 420
            ||:....|:.. :.|..:.:.::.:..|....|              :..|.|.|..: ...||:
Worm   539 ECEAQGYPSPV-IKWLKDGRPVKQSIYASSATSESKCLPEDFCTQTVASTLTLAGPLKWSDKGNF 602

  Fly   421 TCTASN----VEGDGDSNVVELKVMYKPIC---RPDQKKIYGVARNEAAEIVCEVDAFPPPENFK 478
            ||.|.|    .:.|..|..: ::|::||:.   :..:|.:........|.|.|:|.|.|.|| |.
Worm   603 TCVADNGSDKTDKDSSSWTI-VRVLHKPVFLNRKFPEKSLAAADIGSQAIIRCKVSARPEPE-FH 665

  Fly   479 WSFNNTAETFDMPQSGFRPHSAQG------STLTYTPVKEMDFGTIMCWADNNVGQQKEPCVFHL 537
            |.|.: :|..:..:..|......|      ..|....|:|.|:|..:|.|.|  |...:..|..|
Worm   666 WMFRD-SEISENERHSFHTVGITGKPDEYEQLLQIESVQESDYGEYVCRATN--GNGGDHVVIEL 727

  Fly   538 IAAGKPEAPTNCTVVNQTSDSLEVYCIEGFDGGMRQWFLMEI--FDQHSGQLQANISAKFAALSV 600
            .....|..|.:...::.||:|:.:..:..||||..|.:::|.  .|..:|::..|  |..:.|::
Worm   728 RKTSPPALPLDLQKLSATSNSVLLGWVPQFDGGADQTYVLETRKIDPFTGEIDGN--APVSKLNI 790

  Fly   601 TGLDA-----GRLFRIYVYAVNGRGRSDAIALDGYTLKAAEKQTVALTSYKGSAQSPDNFELTPI 660
            ..:..     |.|....::...|     ...|..|.|:      :...|.||.:      |.||:
Worm   791 NAVQQDQEIDGTLVSKNIFNFTG-----LTPLSTYNLR------IQAVSEKGES------EFTPV 838

  Fly   661 LSIGIFVGILVAIVCIGIGTIAALKLRSHKHQQQQKFVHPNAKFSRPGNLQI---KDKIS----L 718
            |                   ||:           .:.|..:|....|..|.:   :.||:    |
Worm   839 L-------------------IAS-----------TEDVVEDANMMSPSRLVLDSSEQKINVEPKL 873

  Fly   719 P-------------LSHSEEMYDEKNP--DVVPYNEVDGEYKQKSATQTPSGHLSTTSEVEISCK 768
            |             :..:...:...||  :::|    ..||:.:..| |.:|         :.|.
Worm   874 PSDACTLLYVFLDGIWRTSTCHTSSNPIGNIIP----GREYRARFCT-TANG---------LKCS 924

  Fly   769 PGS---TSGTGIV 778
            |.|   :||:|.|
Worm   925 PVSKTISSGSGSV 937

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
side-VI	NP_001036705.1	IG_like	35..140	CDD:214653	15/106 (14%)
		Ig_3	157..230	CDD:290638	21/76 (28%)
		IG_like	165..242	CDD:214653	24/88 (27%)
		Ig	265..343	CDD:299845	23/82 (28%)
		IG_like	267..343	CDD:214653	23/80 (29%)
		IG_like	363..440	CDD:214653	19/95 (20%)
		IGc2	364..429	CDD:197706	16/83 (19%)
		IG_like	456..532	CDD:214653	23/81 (28%)
		Ig_3	456..524	CDD:290638	21/73 (29%)
		fn3	545..622	CDD:278470	18/83 (22%)
igcm-1	NP_508166.1	Ig	45..119	CDD:299845
		Ig	146..226	CDD:299845
		Ig_3	245..316	CDD:290638	19/121 (16%)
		IG_like	258..329	CDD:214653	19/125 (15%)
		IG_like	338..398	CDD:214653	21/75 (28%)
		IGc2	347..398	CDD:197706	19/65 (29%)
		Ig_2	429..513	CDD:290606	26/100 (26%)
		IG_like	437..513	CDD:214653	24/92 (26%)
		Ig	537..615	CDD:143165	15/78 (19%)
		IG_like	644..728	CDD:214653	24/87 (28%)
		IGc2	646..719	CDD:197706	23/76 (30%)
		FN3	733..843	CDD:238020	31/158 (20%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	42	1.000	Domainoid score	I8450
eggNOG	1	0.900	-	-		E1_KOG3515
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	3	2.810