Protein Alignment side-III and nphs1

DIOPT Version :10

• Sequence 1: NP_001036681.1
• Gene: side-III / 4379844
• FlyBaseID: FBgn0083949
• Length: 1689
• Species: Drosophila melanogaster
• Sequence 2: XP_073779348.1
• Gene: nphs1 / 692352
• ZFINID: ZDB-GENE-051102-1
• Length: 1287
• Species: Danio rerio
• Alignment Length: 604
• Identity: 120/604 - (19%)
• Similarity: 194/604 - (32%)
• Gaps: 178/604 - (29%)

  Fly    14 TTSYNANIRRSCLALFALFLFAAHISLTSGQIDWDDDDDPVSTVAVEAVLGRTASLP-------- 70
            |...|..:|....||....:..|     ||.:.|..|.         .:||...|||
Zfish    76 TEPRNVTVRAGATALLKCEVLRA-----SGAVQWVKDG---------LLLGPLRSLPGYPRYSMT 126

  Fly    71 ------------CDIEPEAKDDRVYMVLWFRESAGKPLYSFDVRGRPFEKALYWSDTNSFGPRAY 123
                        .|:..|  ||..|.....|..:.:|:.|..|          |.:......:.|
Zfish   127 GDQKKGQYHLQILDVTLE--DDGPYECQVGRSESSRPIVSRTV----------WLNVQIPSSQPY 179

  Fly   124 F--------VTGQQ------------PAKL-------------------SVDNIQ---------- 139
            |        |.|:|            ||::                   |.|.:|
Zfish   180 FQLESEEPWVEGEQYTVTCIAPDAKPPAEITMFRDGEELLESESYTMSGSQDKLQNTHAEVTIRA 244

  Fly   140 --LDDEGVYRCRVDFQNSP-TRNHRINLTVIVPPHQILVYDASGRDVAGAVGPLLEGDNIVLTCE 201
              .||.....||.....|| .....:.:.|..||...::......:|..       |..:.:.|.
Zfish   245 RSSDDTRRLTCRAKNPASPRALETGMTMKVYFPPQAPMIMGLENEEVKA-------GSFLKVVCM 302

  Fly   202 VRGGRPEPTVTWMNGTRTLEAGSGVSM--GRHVTVNRLEVAQISRSALNNTYRCQASNTKLVAPV 264
            ..||.|..|:.|......|.....|..  .|..:|.::||......|:   .:||:.|....:|:
Zfish   303 SYGGNPLATLHWTKNGEVLSTSWDVDFVSRRASSVLKMEVKPEDNHAV---LQCQSINQVTRSPM 364

  Fly   265 ERSIRIEMLLKPTSVNLTNKLKVFASNTQYNLTCIVAGSVPDTEIKWTQNNRPFKRGLLSTSQ-S 328
            ..:..:.:|.:|..|.|....:. ....:.||:|..:.|.|...|:|....:...|..::.:: .
Zfish   365 SLTRTLTVLFEPAEVTLLGSFEA-VEGEEINLSCSTSSSNPPVHIRWWLGFKELNRTEVTFAEGD 428

  Fly   329 NG--RVISTLTFYPQPEDDGTMLKCEGSNPRLQNSAIEDSLMMNVIYPPQ----------VTLSL 381
            ||  ..:|.||.....||:|..|:||..|...:.|::..:.:: |.||||          |.|..
Zfish   429 NGGMMTVSNLTHKVSREDNGLSLQCEAFNKGTRFSSVRAAELI-VYYPPQKVWLDAPPPNVFLHS 492

  Fly   382 GSTLRPDDIKEGDDVYFECHIKSNPKEHRIMWSHDGQPVTQNVSWGIIISTRSLVLQRVGRIHS- 445
            |||||                       .:.:|..|.| |..::|   :....:||....::.|
Zfish   493 GSTLR-----------------------LVCFSSGGNP-TGQLTW---LKNNKVVLTASKQVSSE 530

  Fly   446 -----------------GFYACSAANDRGETQSAPVNLRIRYAPVCSSSSITVIGASLE----ED 489
                             ..|.|.::|...:..|.....|:.:..|    |:.::....|    :.
Zfish   531 RGVSRELLLILHPSDNLATYRCDSSNKAKKVLSTQTKFRVLFPAV----SVKIVAKQKELRRGQT 591

  Fly   490 VPIPCRVNSDPPEIDFEWT 508
            :.:.|...|..|..:..|:
Zfish   592 LDLDCLAGSSNPTANISWS 610

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
side-III	NP_001036681.1	V-set	59..166	CDD:462230	31/178 (17%)
		Ig_3	190..257	CDD:464046	16/68 (24%)
		Ig	289..359	CDD:472250	20/72 (28%)
		Ig strand C	308..312	CDD:409468	1/3 (33%)
		Ig strand E	335..338	CDD:409468	1/2 (50%)
		Ig strand F	348..353	CDD:409468	2/4 (50%)
		Ig_3	374..454	CDD:464046	20/107 (19%)
nphs1	XP_073779348.1	None