DRSC/TRiP Functional Genomics Resources

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Protein Alignment side-III and Nphs1

DIOPT Version :9

Sequence 1:NP_001036681.1 Gene:side-III / 4379844 FlyBaseID:FBgn0083949 Length:1689 Species:Drosophila melanogaster
Sequence 2:NP_072150.1 Gene:Nphs1 / 64563 RGDID:620460 Length:1252 Species:Rattus norvegicus


Alignment Length:1359 Identity:274/1359 - (20%)
Similarity:417/1359 - (30%) Gaps:479/1359 - (35%)


- Green bases have known domain annotations that are detailed below.


  Fly     5 AKRTSTMPLTTSYNANIRRSCLALFALFLFAAHISLTSGQIDWDDDDDPVSTVA----------V 59
            |||.:.....||   .|.|:. :|..|.|..   .||||..     :.||.|.|          :
  Rat     3 AKRVTVRGARTS---PIHRTS-SLTPLLLMG---MLTSGLA-----ESPVPTSAPQGFWALSENL 55

  Fly    60 EAVLGRTASLPCDIEPEAKDDRVYMVLWFRES---------AGKPLYSFDVRGRPFEKALYWSDT 115
            .||.|.|..|.|.:.....     :|.|.::.         .|.|.||.:               
  Rat    56 TAVEGTTVKLWCGVRAPGS-----VVQWAKDGLLLGPNPKMPGFPRYSLE--------------- 100

  Fly   116 NSFGPRAYFVTGQQPAKLSVDNIQLDDEGVYRCRVDFQN------SPTRNHRINLTVIVPPHQIL 174
               |.||     :....|.::...|.|:..|.|:|....      ||    ::.|:::|.|..:|
  Rat   101 ---GDRA-----KGEFHLLIEACDLSDDAEYECQVGRSELGPELVSP----KVILSILVSPKVLL 153

  Fly   175 VYDASGRDVAGAVG--------------------------------------------------- 188
            :...:|..|....|                                                   
  Rat   154 LTPEAGSTVTWVAGQEYVVTCVSGDAKPAPDITFIQSGRTILDVSSNVNEGSEEKLCITEAEARV 218

  Fly   189 --------------------------------------PLLE-----------GDNIVLTCEVRG 204
                                                  |:::           |:|:.|.|..||
  Rat   219 IPQSSDNGQLLVCEGSNPALDTPIKASFTMNILFPPGPPVIDWPGLNEGHVRAGENLELPCTARG 283

  Fly   205 GRPEPTVTWMNGTRTLEAGSGVSMGRHVTVNRLEVAQ-ISRSALNNTYR---------CQASNTK 259
            |.|..|:.|:...:.:....|.           |.|| ::.|.|..|.|         ||:.|:.
  Rat   284 GNPPATLQWLKNGKPVSTAWGT-----------EHAQAVAHSVLVMTVRPEDHGARLSCQSYNSV 337

  Fly   260 LVAPVERSIRIEMLLKPTSVNLTNKLKVFASNTQYNLTCIVAGSVPDTEIKWTQNNRPFKRGLLS 324
            .....||||.:::...|:::.:...:.. :.|....|.|:...|.|...::|....|.    ||.
  Rat   338 SAGTQERSITLQVTFPPSAITILGSVSQ-SENKNVTLCCLTKSSRPRVLLRWWLGGRQ----LLP 397

  Fly   325 TSQS------NGRV-ISTLTFYPQPEDDGTMLKCEGSNPRLQNSAIEDSLMMNVIYPPQVTLSLG 382
            |.::      .|.: :|.|||..:.||:|..|.||..:........:.||.:||.||.|.....|
  Rat   398 TDETVMDGLHGGHISMSNLTFLVRREDNGLPLTCEAFSDAFSKETFKKSLTLNVKYPAQKLWIEG 462

  Fly   383 STLRPDD--IKEGDDVYFEC-HIKSNPKEHRIMWSHDGQPVTQ--------NVSWGII-----IS 431
            .   |:.  |:.|..|...| .|..|| :..::|..|.:||::        .|..|.:     ..
  Rat   463 P---PEGQYIRTGTRVRLVCLAIGGNP-DPSLIWFKDSRPVSEPRQPQEPRRVQLGSVEKSGSTF 523

  Fly   432 TRSLVLQRVGRIHSGFYACSAANDRGETQSA----PVNLRIRYAPVCSSSSITVIGASLEEDVPI 492
            :|.|||......:...::|.|......||..    |.||.|     .::||....|.:|.    :
  Rat   524 SRELVLIIGPPDNRAKFSCKAGQLSASTQLVVQFPPTNLTI-----LANSSALRPGDALN----L 579

  Fly   493 PC-RVNSDPPEIDFEWTFSTSGEHFEVPSGHYATIQDPTMTTTSDVRRTV---VESNE------- 546
            .| .::|:|| ::..|  ...||..|    ..|..........|...|:|   |.|.:       
  Rat   580 TCVSISSNPP-VNLSW--DKEGERLE----DVAAKPQSAPFKGSAASRSVFLRVSSRDHGQRVTC 637

  Fly   547 -THFESYVETVS-----ELIYTPK--GER-------DYGTLACYGRNAIGKQSDPCV-------- 588
             .|.|:..||||     .::|.|:  ||:       :.|.:..    .:...::|..        
  Rat   638 RAHSEALRETVSSFYRFNVLYPPEFLGEQVRAVTVVEQGQVLL----PVSVSANPAPEAFNWTFR 698

  Fly   589 -FQVVPAAKP-------GALR--NCTLRP------------------------YVVTSASLNSSN 619
             :::.||..|       |||:  |.|...                        |..|..:|....
  Rat   699 GYRLSPAGGPRHRILSGGALQLWNVTRADDGFYQLHCQNSEGTAEALLKLDVHYAPTIRALRDPT 763

  Fly   620 QT----------TMHANQILPTQY-----GRHES--NYPHMEYV----------RERHNSSGGN- 656
            :.          |:.||.|||..:     |..|.  |...||.|          |:...|..|. 
  Rat   764 EVNVGGSVDIVCTVDANPILPEMFSWERLGEEEEDLNLDDMEKVSKGSTGRLRIRQAKLSQAGAY 828

  Fly   657 ----NNGTAPAAGRNNVANKNMRGRTSAGQAKSNNKQLTQQQLQRLKKRTSFTPSQTLAAIERQR 717
                :||.||||          ||                  |.||..|  |.|           
  Rat   829 QCIVDNGVAPAA----------RG------------------LVRLVVR--FAP----------- 852

  Fly   718 QRKQLSQQQQQLQQQHHQATATKSGGDN--------KPDGSPAKS---SKQRMRRASRDPQIQQQ 771
               |:.|..        ..|...:.||:        :..|.|...   :|..:....:||:..:.
  Rat   853 ---QVDQPT--------PLTKVAAAGDSTSSATLHCRARGVPNIDFTWTKNGVPLDLQDPRYTEH 906

  Fly   772 QQHQQQQQHQLHAATSITSSQRKQAESNLSTSHLGKGSSSSSRSRRSSSSNINSKSNNGKQPAKY 836
            :.||......|....:::::|........:|:.||           |..:||...|.:...|...
  Rat   907 RYHQGVVHSSLLTIANVSAAQDYALFKCTATNALG-----------SDHTNIQLVSISRPDPPLG 960

  Fly   837 FNKRQKNMHKQKHQQKLKQLKGTTNEHNSNIIHHYAALSSSLRRRKRLAANDILATVAAASTSAS 901
            .    |.:....|...|:...|............|.||.:     ......|:|.|.|...|...
  Rat   961 L----KVVSISPHSVGLEWKPGFDGGLPQRFQIRYEALET-----PGFLHVDVLPTQATTFTLTG 1016

  Fly   902 LSSPPASSAASLAATATAAVEIEQDVSAVDAPAADSGSNNKRSRKSLTIL-DKQKQQQEQQQL-- 963
            |..........||:.|                ..|||..:|..:.|:|.. ..|..:....||  
  Rat  1017 LKPSTRYRIWLLASNA----------------LGDSGLTDKGIQVSVTTPGPDQAPEDTDHQLPT 1065

  Fly   964 -LPPNAPQISNQPVAAISGNNVKETAATSAHG--------AVAAGVKDKAPSSKEDSTDNDNDSD 1019
             |||..|::...||....|..:..:.|:...|        .:|..:.:|..:..||...|:.:..
  Rat  1066 ELPPGPPRLPLLPVLFAVGGLLLLSNASCVGGLLWRRRLRRLAEEISEKTEAGSEDRIRNEYEES 1130

  Fly  1020 ---GDEDDDDDDDDGAEID-----------------AETETNDEEEDEDEG--GEAHDD 1056
               ||.|........||:|                 .|...:...|.||..  |..||:
  Rat  1131 QWTGDRDTRSSTVSTAEVDPNYYSMRDFSPQLPPTLEEVLYHQGAEGEDMAFPGHLHDE 1189

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
side-IIINP_001036681.1 IG_like 59..166 CDD:214653 24/121 (20%)
V-set 59..166 CDD:284989 24/121 (20%)
ig 190..268 CDD:278476 23/98 (23%)
IG_like 192..259 CDD:214653 21/87 (24%)
Ig 296..361 CDD:299845 20/71 (28%)
IG_like 391..468 CDD:214653 23/94 (24%)
IGc2 392..454 CDD:197706 18/75 (24%)
Nphs1NP_072150.1 Ig 52..128 CDD:299845 20/103 (19%)
IG_like 52..127 CDD:214653 20/102 (20%)
C2-set_2 155..242 CDD:285423 3/86 (3%)
Ig_3 256..335 CDD:290638 21/89 (24%)
IG_like 268..350 CDD:214653 25/92 (27%)
C2-set_2 358..440 CDD:285423 21/86 (24%)
I-set 460..555 CDD:254352 23/98 (23%)
Ig 472..555 CDD:299845 20/83 (24%)
Ig 563..646 CDD:299845 21/98 (21%)
IG_like 670..750 CDD:214653 10/83 (12%)
Ig 676..750 CDD:299845 10/77 (13%)
Ig_3 753..834 CDD:290638 17/80 (21%)
IG_like 762..848 CDD:214653 26/113 (23%)
Ig 848..956 CDD:299845 24/142 (17%)
IG_like 859..949 CDD:214653 18/100 (18%)
FN3 955..1049 CDD:238020 22/118 (19%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1043..1067 5/23 (22%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1113..1144 7/30 (23%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E1_KOG3515
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 1 1.000 - -
TreeFam 00.000 Not matched by this tool.
32.810

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