DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment side-III and NPHS1

DIOPT Version :9

Sequence 1:	NP_001036681.1	Gene:	side-III / 4379844	FlyBaseID:	FBgn0083949	Length:	1689	Species:	Drosophila melanogaster
Sequence 2:	NP_004637.1	Gene:	NPHS1 / 4868	HGNCID:	7908	Length:	1241	Species:	Homo sapiens

Alignment Length:	1303	Identity:	243/1303 - (18%)
Similarity:	407/1303 - (31%)	Gaps:	434/1303 - (33%)

- Green bases have known domain annotations that are detailed below.

  Fly   109 ALYWS-DTNSFGP-------RAYFVTGQQPAK----LSVDNIQLDDEGVYRCRVDFQN------S 155
            |:.|: |....||       ..|.:.| .||:    |.::...|.|:..|.|:|....      |
Human    61 AVQWAKDGLLLGPDPRIPGFPRYRLEG-DPARGEFHLHIEACDLSDDAEYECQVGRSEMGPELVS 124

  Fly   156 PTRNHRINLTVIVPPHQILVYDASGRDVAGAVG-------------------------------- 188
            |    |:.|:::|||..:|:...:|..|....|
Human   125 P----RVILSILVPPKLLLLTPEAGTMVTWVAGQEYVVNCVSGDAKPAPDITILLSGQTISDISA 185

  Fly   189 ---------------------------------------------------------PLLE---- 192
                                                                     |::|
Human   186 NVNEGSQQKLFTVEATARVTPRSSDNRQLLVCEASSPALEAPIKASFTVNVLFPPGPPVIEWPGL 250

  Fly   193 -------GDNIVLTCEVRGGRPEPTVTWMNGTRTLEAGSGVSMGRHVTVNRLEVAQISRSALNNT 250
                   |.::.|.|..|||.|..|:.|:...:.:....|..          ....::||.|..|
Human   251 DEGHVRAGQSLELPCVARGGNPLATLQWLKNGQPVSTAWGTE----------HTQAVARSVLVMT 305

  Fly   251 YR---------CQASNTKLVAPVERSIRIEMLLKPTSVNLTNKLKVFASNTQ---YNLTCIVAGS 303
            .|         |:|.|:......|..|.:::...|:::.:...    ||.|:   ..|:|:...|
Human   306 VRPEDHGAQLSCEAHNSVSAGTQEHGITLQVTFPPSAIIILGS----ASQTENKNVTLSCVSKSS 366

  Fly   304 VPDTEIKWTQNNR---PFKRGLLSTSQSNGRVISTLTFYPQPEDDGTMLKCEGSNPRLQNSAIED 365
            .|...::|....|   |.:..::.........:|.|||..:.||:|..|.||..:........:.
Human   367 RPRVLLRWWLGWRQLLPMEETVMDGLHGGHISMSNLTFLARREDNGLTLTCEAFSEAFTKETFKK 431

  Fly   366 SLMMNVIYPPQVTLSLGSTLRPDDIKEGDDVYFEC-HIKSNPKEHRIMWSHDGQPVTQN------ 423
            ||::||.||.| .|.:........::.|..|...| .|..|| |..:||..|.:.||::
Human   432 SLILNVKYPAQ-KLWIEGPPEGQKLRAGTRVRLVCLAIGGNP-EPSLMWYKDSRTVTESRLPQES 494

  Fly   424 --VSWGII-----ISTRSLVLQRVGRIHSGFYACSAANDRGETQSAPVNLRIRYAPVCSSSSITV 481
              |..|.:     ..:|.|||......:...:.|.|..     .||...|.:::.|    :::|:
Human   495 RRVHLGSVEKSGSTFSRELVLVTGPSDNQAKFTCKAGQ-----LSASTQLAVQFPP----TNVTI 550

  Fly   482 I--GASLE--EDVPIPC-RVNSDPPEIDFEWTFSTSGEHFEVPSGHYATIQDPTMTTTSDVRRTV 541
            :  .::|.  :.:.:.| .|:|:|| ::..|  ...||..|   |..|..:......::..|..:
Human   551 LANASALRPGDALNLTCVSVSSNPP-VNLSW--DKEGERLE---GVAAPPRRAPFKGSAAARSVL 609

  Fly   542 VESN----------ETHFESYVETVS-----ELIYTPK--GERDYGTLACYGRNA---IGKQSDP 586
            ::.:          ..|.....||||     .::|.|:  ||:.....|.....|   :...::|
Human   610 LQVSSRDHGQRVTCRAHSAELRETVSSFYRLNVLYRPEFLGEQVLVVTAVEQGEALLPVSVSANP 674

  Fly   587 CV---------FQVVPAAKP-------GALR--NCT---------------------LR---PYV 609
            ..         :::.||..|       |||.  |.|                     ||   .|.
Human   675 APEAFNWTFRGYRLSPAGGPRHRILSSGALHLWNVTRADDGLYQLHCQNSEGTAEARLRLDVHYA 739

  Fly   610 VTSASLNSSNQT----------TMHANQILPTQYG-------RHESNYPHMEYV--------RER 649
            .|..:|....:.          |:.||.|||..:.       ..:.:...||.:        |..
Human   740 PTIRALQDPTEVNVGGSVDIVCTVDANPILPGMFNWERLGEDEEDQSLDDMEKISRGPTGRLRIH 804

  Fly   650 H---NSSGGN----NNGTAPAAGRNNVANKNMRGRTSAGQAKSNNKQLTQQQLQRLKKRTSFTPS 707
            |   ..:|..    :||.||.|.|                            |.||..|  |.|
Human   805 HAKLAQAGAYQCIVDNGVAPPARR----------------------------LLRLVVR--FAP- 838

  Fly   708 QTLAAIERQRQRKQLSQQQQQLQQQHHQATATK--SGGDN--------KPDGSP---AKSSKQRM 759
                                   |..|....||  :.||:        :..|.|   ...:|..:
Human   839 -----------------------QVEHPTPLTKVAAAGDSTSSATLHCRARGVPNIVFTWTKNGV 880

  Fly   760 RRASRDPQIQQQQQHQQQQQHQLHAATSITSSQRKQAESNLSTSHLGKGSSSSSRSRRSSSSNIN 824
            ....:||:..:...||......|....:::::|.....:..:|:.||           |..:||.
Human   881 PLDLQDPRYTEHTYHQGGVHSSLLTIANVSAAQDYALFTCTATNALG-----------SDQTNIQ 934

  Fly   825 SKSNNGKQPAKYFNKRQKNMHKQKHQQKLKQLKGTTNEHNSNIIHHYAALSSSLRRRKRLAANDI 889
            ..|.:...|....    |.:....|...|:...|............|.||.:     ......|:
Human   935 LVSISRPDPPSGL----KVVSLTPHSVGLEWKPGFDGGLPQRFCIRYEALGT-----PGFHYVDV 990

  Fly   890 LATVAAASTSASLSSPPASSAASLAATATAAVEIEQDVSAVDAPAADSGSNNKRSRKSLT---IL 951
            :...|...|...|..........||:.|                ..|||..:|.::..:|   :.
Human   991 VPPQATTFTLTGLQPSTRYRVWLLASNA----------------LGDSGLADKGTQLPITTPGLH 1039

  Fly   952 DKQKQQQEQQQLLPPNAPQ-ISNQPVAAISGNNVKETAATSAHGA--------VAAGVKDKAPS- 1006
            ....:.::|....||:.|. :...||....|..:..:.|:...|.        :|.|:.:|..:
Human  1040 QPSGEPEDQLPTEPPSGPSGLPLLPVLFALGGLLLLSNASCVGGVLWQRRLRRLAEGISEKTEAG 1104

  Fly  1007 SKEDSTDNDNDSD---GDEDDDDDDDDGAEID----------AETETNDEEEDEDEGGEAHDDD- 1057
            |:||...|:.:..   |:.|.........|.:          .:.....||.....|....|:|
Human  1105 SEEDRVRNEYEESQWTGERDTQSSTVSTTEAEPYYRSLRDFSPQLPPTQEEVSYSRGFTGEDEDM 1169

  Fly  1058 ---ADLDEDVAQLATDA-------DYLADGPGDLQ-EYETVEEVDGQAKHVHMLSLEEQL--DLE 1109
               ..|.::|.:....:       |.:..||.||. ..:|.::..|         :.:|:  ||:
Human  1170 AFPGHLYDEVERTYPPSGAWGPLYDEVQMGPWDLHWPEDTYQDPRG---------IYDQVAGDLD 1225

  Fly  1110 SLE 1112
            :||
Human  1226 TLE 1228

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
side-III	NP_001036681.1	IG_like	59..166	CDD:214653	19/74 (26%)
		V-set	59..166	CDD:284989	19/74 (26%)
		ig	190..268	CDD:278476	20/97 (21%)
		IG_like	192..259	CDD:214653	19/86 (22%)
		Ig	296..361	CDD:299845	17/67 (25%)
		IG_like	391..468	CDD:214653	23/90 (26%)
		IGc2	392..454	CDD:197706	20/75 (27%)
NPHS1	NP_004637.1	V-set	38..119	CDD:284989	15/58 (26%)
		IG_like	38..113	CDD:214653	14/52 (27%)
		C2-set_2	141..228	CDD:285423	3/86 (3%)
		Ig	240..321	CDD:299845	19/90 (21%)
		IG_like	254..336	CDD:214653	20/91 (22%)
		Ig	345..424	CDD:299845	20/82 (24%)
		Ig	445..530	CDD:299845	19/85 (22%)
		I-set	446..541	CDD:254352	23/100 (23%)
		Ig	549..632	CDD:299845	15/88 (17%)
		IG_like	558..642	CDD:214653	17/89 (19%)
		I-set	646..736	CDD:254352	16/89 (18%)
		Ig	662..736	CDD:299845	12/73 (16%)
		Ig_3	739..820	CDD:290638	13/80 (16%)
		IG_like	748..821	CDD:214653	11/72 (15%)
		Ig8_hNephrin_like	834..942	CDD:143250	25/144 (17%)
		IG_like	845..935	CDD:214653	19/100 (19%)
		fn3	942..1023	CDD:278470	16/105 (15%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1025..1057		5/31 (16%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1099..1137		8/37 (22%)
		Binds to NPHS2	1160..1241		17/78 (22%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3515
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.810