DRSC/TRiP Functional Genomics Resources

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Protein Alignment side-III and NPHS1

DIOPT Version :10

Sequence 1:NP_001036681.1 Gene:side-III / 4379844 FlyBaseID:FBgn0083949 Length:1689 Species:Drosophila melanogaster
Sequence 2:NP_004637.1 Gene:NPHS1 / 4868 HGNCID:7908 Length:1241 Species:Homo sapiens


Alignment Length:1303 Identity:243/1303 - (18%)
Similarity:407/1303 - (31%) Gaps:434/1303 - (33%)


- Green bases have known domain annotations that are detailed below.


  Fly   109 ALYWS-DTNSFGP-------RAYFVTGQQPAK----LSVDNIQLDDEGVYRCRVDFQN------S 155
            |:.|: |....||       ..|.:.| .||:    |.::...|.|:..|.|:|....      |
Human    61 AVQWAKDGLLLGPDPRIPGFPRYRLEG-DPARGEFHLHIEACDLSDDAEYECQVGRSEMGPELVS 124

  Fly   156 PTRNHRINLTVIVPPHQILVYDASGRDVAGAVG-------------------------------- 188
            |    |:.|:::|||..:|:...:|..|....|                                
Human   125 P----RVILSILVPPKLLLLTPEAGTMVTWVAGQEYVVNCVSGDAKPAPDITILLSGQTISDISA 185

  Fly   189 ---------------------------------------------------------PLLE---- 192
                                                                     |::|    
Human   186 NVNEGSQQKLFTVEATARVTPRSSDNRQLLVCEASSPALEAPIKASFTVNVLFPPGPPVIEWPGL 250

  Fly   193 -------GDNIVLTCEVRGGRPEPTVTWMNGTRTLEAGSGVSMGRHVTVNRLEVAQISRSALNNT 250
                   |.::.|.|..|||.|..|:.|:...:.:....|..          ....::||.|..|
Human   251 DEGHVRAGQSLELPCVARGGNPLATLQWLKNGQPVSTAWGTE----------HTQAVARSVLVMT 305

  Fly   251 YR---------CQASNTKLVAPVERSIRIEMLLKPTSVNLTNKLKVFASNTQ---YNLTCIVAGS 303
            .|         |:|.|:......|..|.:::...|:::.:...    ||.|:   ..|:|:...|
Human   306 VRPEDHGAQLSCEAHNSVSAGTQEHGITLQVTFPPSAIIILGS----ASQTENKNVTLSCVSKSS 366

  Fly   304 VPDTEIKWTQNNR---PFKRGLLSTSQSNGRVISTLTFYPQPEDDGTMLKCEGSNPRLQNSAIED 365
            .|...::|....|   |.:..::.........:|.|||..:.||:|..|.||..:........:.
Human   367 RPRVLLRWWLGWRQLLPMEETVMDGLHGGHISMSNLTFLARREDNGLTLTCEAFSEAFTKETFKK 431

  Fly   366 SLMMNVIYPPQVTLSLGSTLRPDDIKEGDDVYFEC-HIKSNPKEHRIMWSHDGQPVTQN------ 423
            ||::||.||.| .|.:........::.|..|...| .|..|| |..:||..|.:.||::      
Human   432 SLILNVKYPAQ-KLWIEGPPEGQKLRAGTRVRLVCLAIGGNP-EPSLMWYKDSRTVTESRLPQES 494

  Fly   424 --VSWGII-----ISTRSLVLQRVGRIHSGFYACSAANDRGETQSAPVNLRIRYAPVCSSSSITV 481
              |..|.:     ..:|.|||......:...:.|.|..     .||...|.:::.|    :::|:
Human   495 RRVHLGSVEKSGSTFSRELVLVTGPSDNQAKFTCKAGQ-----LSASTQLAVQFPP----TNVTI 550

  Fly   482 I--GASLE--EDVPIPC-RVNSDPPEIDFEWTFSTSGEHFEVPSGHYATIQDPTMTTTSDVRRTV 541
            :  .::|.  :.:.:.| .|:|:|| ::..|  ...||..|   |..|..:......::..|..:
Human   551 LANASALRPGDALNLTCVSVSSNPP-VNLSW--DKEGERLE---GVAAPPRRAPFKGSAAARSVL 609

  Fly   542 VESN----------ETHFESYVETVS-----ELIYTPK--GERDYGTLACYGRNA---IGKQSDP 586
            ::.:          ..|.....||||     .::|.|:  ||:.....|.....|   :...::|
Human   610 LQVSSRDHGQRVTCRAHSAELRETVSSFYRLNVLYRPEFLGEQVLVVTAVEQGEALLPVSVSANP 674

  Fly   587 CV---------FQVVPAAKP-------GALR--NCT---------------------LR---PYV 609
            ..         :::.||..|       |||.  |.|                     ||   .|.
Human   675 APEAFNWTFRGYRLSPAGGPRHRILSSGALHLWNVTRADDGLYQLHCQNSEGTAEARLRLDVHYA 739

  Fly   610 VTSASLNSSNQT----------TMHANQILPTQYG-------RHESNYPHMEYV--------RER 649
            .|..:|....:.          |:.||.|||..:.       ..:.:...||.:        |..
Human   740 PTIRALQDPTEVNVGGSVDIVCTVDANPILPGMFNWERLGEDEEDQSLDDMEKISRGPTGRLRIH 804

  Fly   650 H---NSSGGN----NNGTAPAAGRNNVANKNMRGRTSAGQAKSNNKQLTQQQLQRLKKRTSFTPS 707
            |   ..:|..    :||.||.|.|                            |.||..|  |.| 
Human   805 HAKLAQAGAYQCIVDNGVAPPARR----------------------------LLRLVVR--FAP- 838

  Fly   708 QTLAAIERQRQRKQLSQQQQQLQQQHHQATATK--SGGDN--------KPDGSP---AKSSKQRM 759
                                   |..|....||  :.||:        :..|.|   ...:|..:
Human   839 -----------------------QVEHPTPLTKVAAAGDSTSSATLHCRARGVPNIVFTWTKNGV 880

  Fly   760 RRASRDPQIQQQQQHQQQQQHQLHAATSITSSQRKQAESNLSTSHLGKGSSSSSRSRRSSSSNIN 824
            ....:||:..:...||......|....:::::|.....:..:|:.||           |..:||.
Human   881 PLDLQDPRYTEHTYHQGGVHSSLLTIANVSAAQDYALFTCTATNALG-----------SDQTNIQ 934

  Fly   825 SKSNNGKQPAKYFNKRQKNMHKQKHQQKLKQLKGTTNEHNSNIIHHYAALSSSLRRRKRLAANDI 889
            ..|.:...|....    |.:....|...|:...|............|.||.:     ......|:
Human   935 LVSISRPDPPSGL----KVVSLTPHSVGLEWKPGFDGGLPQRFCIRYEALGT-----PGFHYVDV 990

  Fly   890 LATVAAASTSASLSSPPASSAASLAATATAAVEIEQDVSAVDAPAADSGSNNKRSRKSLT---IL 951
            :...|...|...|..........||:.|                ..|||..:|.::..:|   :.
Human   991 VPPQATTFTLTGLQPSTRYRVWLLASNA----------------LGDSGLADKGTQLPITTPGLH 1039

  Fly   952 DKQKQQQEQQQLLPPNAPQ-ISNQPVAAISGNNVKETAATSAHGA--------VAAGVKDKAPS- 1006
            ....:.::|....||:.|. :...||....|..:..:.|:...|.        :|.|:.:|..: 
Human  1040 QPSGEPEDQLPTEPPSGPSGLPLLPVLFALGGLLLLSNASCVGGVLWQRRLRRLAEGISEKTEAG 1104

  Fly  1007 SKEDSTDNDNDSD---GDEDDDDDDDDGAEID----------AETETNDEEEDEDEGGEAHDDD- 1057
            |:||...|:.:..   |:.|.........|.:          .:.....||.....|....|:| 
Human  1105 SEEDRVRNEYEESQWTGERDTQSSTVSTTEAEPYYRSLRDFSPQLPPTQEEVSYSRGFTGEDEDM 1169

  Fly  1058 ---ADLDEDVAQLATDA-------DYLADGPGDLQ-EYETVEEVDGQAKHVHMLSLEEQL--DLE 1109
               ..|.::|.:....:       |.:..||.||. ..:|.::..|         :.:|:  ||:
Human  1170 AFPGHLYDEVERTYPPSGAWGPLYDEVQMGPWDLHWPEDTYQDPRG---------IYDQVAGDLD 1225

  Fly  1110 SLE 1112
            :||
Human  1226 TLE 1228

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
side-IIINP_001036681.1 V-set 59..166 CDD:462230 19/74 (26%)
Ig_3 190..257 CDD:464046 18/86 (21%)
Ig 289..359 CDD:472250 20/75 (27%)
Ig strand C 308..312 CDD:409468 0/3 (0%)
Ig strand E 335..338 CDD:409468 1/2 (50%)
Ig strand F 348..353 CDD:409468 2/4 (50%)
Ig_3 374..454 CDD:464046 23/93 (25%)
NPHS1NP_004637.1 V-set 38..119 CDD:462230 15/58 (26%)
C2-set_2 141..228 CDD:400489 3/86 (3%)
Ig strand B 156..160 CDD:409353 0/3 (0%)
Ig strand C 170..174 CDD:409353 0/3 (0%)
Ig strand E 200..204 CDD:409353 0/3 (0%)
Ig strand F 214..219 CDD:409353 0/4 (0%)
Ig strand G 229..232 CDD:409353 0/2 (0%)
Ig 237..336 CDD:472250 22/108 (20%)
Ig strand B 261..265 CDD:409353 1/3 (33%)
Ig strand C 275..279 CDD:409353 1/3 (33%)
Ig strand E 300..304 CDD:409353 2/3 (67%)
Ig strand F 314..319 CDD:409353 1/4 (25%)
Ig strand G 332..335 CDD:409353 1/2 (50%)
Ig 345..424 CDD:472250 20/82 (24%)
Ig strand B 357..361 CDD:409353 1/3 (33%)
Ig strand C 371..375 CDD:409353 0/3 (0%)
Ig strand E 400..404 CDD:409353 2/3 (67%)
Ig strand F 414..419 CDD:409353 2/4 (50%)
Ig strand G 430..433 CDD:409353 0/2 (0%)
Ig 446..541 CDD:472250 23/100 (23%)
Ig strand B 461..465 CDD:409353 1/3 (33%)
Ig strand C 475..479 CDD:409353 1/3 (33%)
Ig strand E 510..515 CDD:409353 2/4 (50%)
Ig strand F 525..530 CDD:409353 1/4 (25%)
Ig 549..632 CDD:472250 15/88 (17%)
Ig strand B 563..567 CDD:409353 0/3 (0%)
Ig strand C 577..581 CDD:409353 1/5 (20%)
Ig strand E 606..610 CDD:409353 1/3 (33%)
Ig strand F 620..625 CDD:409353 0/4 (0%)
Ig strand G 635..638 CDD:409353 1/2 (50%)
Ig 646..736 CDD:472250 16/89 (18%)
Ig strand B 664..668 CDD:409353 1/3 (33%)
Ig strand C 678..682 CDD:409353 0/3 (0%)
Ig strand E 702..706 CDD:409353 3/3 (100%)
Ig strand F 716..721 CDD:409353 0/4 (0%)
Ig strand G 729..732 CDD:409353 0/2 (0%)
Ig_3 740..820 CDD:464046 13/79 (16%)
IgC1_hNephrin_like 834..942 CDD:143250 25/144 (17%)
putative Ig strand A 839..844 CDD:143250 2/4 (50%)
putative Ig strand B 859..866 CDD:143250 0/6 (0%)
putative Ig strand C 870..876 CDD:143250 0/5 (0%)
putative Ig strand C' 879..881 CDD:143250 0/1 (0%)
putative Ig strand D 888..891 CDD:143250 0/2 (0%)
putative Ig strand E 898..906 CDD:143250 1/7 (14%)
putative Ig strand F 917..924 CDD:143250 0/6 (0%)
putative Ig strand G 939..942 CDD:143250 0/2 (0%)
FN3 941..1022 CDD:238020 15/105 (14%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1025..1057 5/31 (16%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1099..1137 8/37 (22%)
Binds to NPHS2 1160..1241 17/78 (22%)

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