DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment side-III and side

DIOPT Version :9

Sequence 1:	NP_001036681.1	Gene:	side-III / 4379844	FlyBaseID:	FBgn0083949	Length:	1689	Species:	Drosophila melanogaster
Sequence 2:	NP_001247334.1	Gene:	side / 43300	FlyBaseID:	FBgn0016061	Length:	986	Species:	Drosophila melanogaster

Alignment Length:	884	Identity:	244/884 - (27%)
Similarity:	379/884 - (42%)	Gaps:	166/884 - (18%)

- Green bases have known domain annotations that are detailed below.

  Fly     4 PAKRTSTMPLTT-----------SYNANIRRSCLAL------------FALFLFAAHISLTSGQI 45
            ||.:|:..|..|           ..|.|..|.....            |.|.|......|.|...
  Fly    20 PAMQTTYWPRQTGNSKSKSNTNCKCNINTHRKSRTRCPDNGKTIWAVGFTLVLLTCLQQLKSVSA 84

  Fly    46 DWDDDDDPVSTVA--VEAVLGRTASLPCDIEPEAKDDRVYMVLWFRESAGKPLYSFDVRGRPFEK 108
            |.:..|...:..|  |.|.||:|..||||:.|....|.|.::|||:::.|.||||.|.||...:.
  Fly    85 DEESQDFQKNIPARLVWAALGKTVELPCDLTPPTSQDSVKLLLWFKDTTGIPLYSLDSRGGNVKL 149

  Fly   109 ALYWSDTNSFGPRAYFVTGQQP--AKLSVDNIQLDDEGVYRCRVDFQNSPTRNHRINLTVIVPPH 171
            |.:.:..:..|.|.:|..|..|  ::|.:::::.:|.|||||||||.||||||.|.|||::|||.
  Fly   150 APHAAIASDLGQRLFFSIGDNPKDSRLQINDVKPEDGGVYRCRVDFFNSPTRNFRHNLTLVVPPE 214

  Fly   172 QILVYDASGRDVAGAVGPLLEGDNIVLTCEVRGGRPEPTVTWMNGTRTLEAGSGVSM--GRHVTV 234
            :..::||.|::::...||..||..:.|.|:||||||.|.|||......|...|..|:  |..|.|
  Fly   215 EPRIFDAQGKEISQMAGPFREGYELFLCCQVRGGRPPPKVTWWRDDTELIGTSHTSVEEGATVMV 279

  Fly   235 NRLEVAQISRSALNNTYRCQASNTKLVAPVERSIRIEMLLKPTSVNLTNKLKVFASNTQYNLTCI 299
            |:|.:...:|........|:|..|:||.||.:.:.:::.|||..|.:....::..:.....:.|.
  Fly   280 NQLLIGTTTRDFYGIRIECRAQGTRLVDPVRKDVTVQVYLKPVRVKIATPNELLTAGQPMPIRCE 344

  Fly   300 VAGSVPDTEIKWTQNNRPFKRG--LLSTSQSNGRV-ISTLTFYPQPEDDGTMLKCEGSNPRLQNS 361
            ..||.|..:|.|..:..|.:..  .:.:.:.:|.: .|.||.....|:|...|.|..:||.....
  Fly   345 SWGSYPAAKITWLLDGEPIRNAEVTVHSDKEDGNITTSILTLKVTSENDNAELTCRATNPWFSGG 409

  Fly   362 AIEDSLMMNVIYPPQVTLSLGSTLRPDDI---KEGDDVYFECHIKSNPKEHRIMWSHDGQPVTQN 423
            ||||..::.|.|||.|::.|.:. .|..:   .||.:|.|:|...:.|......|..:|..::..
  Fly   410 AIEDKRIIRVAYPPTVSVHLANE-DPSRLVTRAEGQNVTFKCRADARPPVTSYSWFKNGMRMSGE 473

  Fly   424 VSWGIIISTRSLVLQRVGRIHSGFYACSAANDRGETQSAPVNLRIRYAPVC-SSSSITVIGASLE 487
                   ||..:.|.::.|..:|.|||.|.|..|||:|:.:.|:::::|.| |.:..|.|||...
  Fly   474 -------STEIMHLTQLERESAGAYACGATNTEGETRSSSLTLKVQFSPRCKSGTEQTSIGAVSL 531

  Fly   488 EDVPIPCRVNSDPPE-IDFEWTFSTSGEHFEVPSGHYATIQDPTMTTTSDVRRTVVESNETHFES 551
            ..:.:.|.|::|||: :.|.||::.:                   ...|.|..:.::||
  Fly   532 HSILVKCEVDADPPDSVRFSWTYNNT-------------------RNVSPVLNSRIQSN------ 571

  Fly   552 YVETVSELIYTPKGERDYGTLACYGRNAIGKQSDPCVFQVVPAAKPGALRNCTLRPYVVTSASLN 616
              ...|.:.|.|:.:.:..||||:..||:|:|:.||:..::||..|.|.:.|.||
  Fly   572 --GLASTVTYLPQTDSELITLACWASNAVGRQTTPCLVHILPANTPEAPKACELR---------- 624

  Fly   617 SSNQTTMHANQILPTQYGRHESNYPHMEYVRERHNSSGGNNNGTAPAAGRNNVANKNMRGRTSAG 681
              |.|.:....:..:..|.  |.|..:|.|       ||:...:....|             |||
  Fly   625 --NDTVLEVVCVAGSDGGL--SQYFMLEVV-------GGDPLYSGDPGG-------------SAG 665

  Fly   682 QAKSN---------------NKQLTQQQLQRLKKRTSFTPSQTLAAIERQRQRKQLSQQQQQLQQ 731
            |.:..               |.|.|...:.|:::.   :|...|..:|..|:.:.|
  Fly   666 QGRGQFSEAIGLGDNEISTLNDQATSAPIFRMQEN---SPQFRLNNLEPGREYQFL--------- 718

  Fly   732 QHHQATATKSGGDNKPDGSPAKSSKQRMRRASRDPQIQQQQQHQQQQQHQLHAATSITSSQRKQA 796
                ..|..:.|.::|   |......|: .|...|..:                 ||.|.....|
  Fly   719 ----VYAVNAKGRSEP---PVVIENVRV-AAQLGPYDE-----------------SILSEDPTPA 758

  Fly   797 ESNLSTSHLGKGSSSSSRSRRSSSSNINSKSNNGKQPAK 835
            |    |:|.|.|....|    .|||.:.:.::.|..|.|
  Fly   759 E----TTHHGGGGVGGS----GSSSGLGTGASTGSGPEK 789

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
side-III	NP_001036681.1	IG_like	59..166	CDD:214653	49/108 (45%)
		V-set	59..166	CDD:284989	49/108 (45%)
		ig	190..268	CDD:278476	30/79 (38%)
		IG_like	192..259	CDD:214653	25/68 (37%)
		Ig	296..361	CDD:299845	17/67 (25%)
		IG_like	391..468	CDD:214653	23/76 (30%)
		IGc2	392..454	CDD:197706	17/61 (28%)
side	NP_001247334.1	V-set	95..211	CDD:284989	51/115 (44%)
		IG_like	100..211	CDD:214653	50/110 (45%)
		Ig	235..301	CDD:299845	24/65 (37%)
		Ig	326..408	CDD:299845	17/81 (21%)
		IG_like	329..407	CDD:214653	17/77 (22%)
		IG_like	435..511	CDD:214653	23/82 (28%)
		Ig_2	442..511	CDD:290606	23/75 (31%)
		FN3	<700..735	CDD:238020	9/53 (17%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	41	1.000	Domainoid score	I12487
eggNOG	1	0.900	-	-		E1_KOG3515
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D23448at33392
OrthoFinder	1	1.000	-	-		FOG0002810
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR23278
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X1676
	7	6.920