DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment side-III and side-VII

DIOPT Version :9

Sequence 1:	NP_001036681.1	Gene:	side-III / 4379844	FlyBaseID:	FBgn0083949	Length:	1689	Species:	Drosophila melanogaster
Sequence 2:	NP_001262432.1	Gene:	side-VII / 41184	FlyBaseID:	FBgn0037736	Length:	939	Species:	Drosophila melanogaster

Alignment Length:	950	Identity:	278/950 - (29%)
Similarity:	430/950 - (45%)	Gaps:	144/950 - (15%)

- Green bases have known domain annotations that are detailed below.

  Fly    31 LFLFAAHISLTSGQIDWDDDDDPVSTVAVEAVLGRTASLPCDIEPEAKDDRVYMVLWFRESAGKP 95
            |.||...:.|....|  ...|.|:.  .:|:::|....|||::.....|:.| :|||:|:..|.|
  Fly     4 LLLFMLALQLIESSI--GSKDVPIH--QIESIVGENIYLPCNVTTYDGDEPV-LVLWYRDDKGTP 63

  Fly    96 LYSFDVRGRPFEKALYWSDTNSFGPRAYFVTGQQPAKLSVDNIQLDDEGVYRCRVDFQNSPTRNH 160
            :||.|:|....:....|||.:.||.||||:..::|.|||:.|.|..|.|.|||||||..:.|.|.
  Fly    64 IYSIDIRAGVSKAPKRWSDDSVFGDRAYFIFDKEPGKLSIQNTQASDSGTYRCRVDFLKAQTINS 128

  Fly   161 RINLTVIVPPHQILVYDASGRDVAGAVGPLLEGDNIVLTCEVRGGRPEPTVTWMNGTRTLEAGSG 225
            ||.|.||.||.|:::.|:|..:.:..|||..|||.:.|.|:|.||.|.||::|......:.....
  Fly   129 RIRLNVISPPKQVIIRDSSNVERSTVVGPYSEGDIVSLKCQVIGGYPTPTISWYRDGIEIPCELS 193

  Fly   226 VSMGRHVTVNRLEVAQISRSALNNTYRCQASNTKLVAPVERSIRIEMLLKPTSVNLTNKLKVFAS 290
            ...|..:....:.:..:.|..||:...|:|.:......||..::|:|...|.::.|....:..::
  Fly   194 HLAGGKIIECEITLPSLGREDLNSRLTCRALSHPRAPIVEAVVQIDMNFAPLNIRLLGAHQPLSA 258

  Fly   291 NTQYNLTCIVAGSVPDTEIKWTQNNRPFKRGLLSTSQSNGRVISTLTFYPQPEDDGTMLKCEGSN 355
            ..:|:|.|..|||.|...|.|.||....::...:||....:..|||:......|.|..|.|:..|
  Fly   259 GRRYDLLCQSAGSRPPAVITWWQNGIRLEKTTETTSSDGNQTTSTLSISLSKSDAGKYLSCKAYN 323

  Fly   356 PRLQNSAIEDSLMMNVIYPPQVTLSLGSTLRPDDIKEGDDVYFECHIKSNPKEHRIMWSHDGQPV 420
            ..:.:..:||...:::.|.|:..:.||::|.|..::||.||||:|.:.::|...||.|.|:.||:
  Fly   324 HAVPSEPLEDGWKLDIQYVPEAYVRLGTSLDPSTLREGTDVYFDCLVMAHPNVFRIEWRHNEQPL 388

  Fly   421 TQNVSWGIIISTRSLVLQRVGRIHSGFYACSAANDRGETQSAPVNLRIRYAPVCSSSSITVIGAS 485
            :.|:|.|:|||..|||||.|.|..:|.|:|...|..||..|||..|.|.|||.|:.:...|.|.:
  Fly   389 SHNISLGVIISNHSLVLQGVTRATAGNYSCVGFNAEGEGISAPFALNILYAPTCAQNQKKVYGIA 453

  Fly   486 LEEDVPIPCRVNSDPPEIDFEWTFSTSGEHFEVPSGHYATIQDPTMTTTSDVRRTVVESNETHFE 550
            .:||..:.|.|:::|.|::|.|||:.|.|..:|.:.|                  ::.|.
  Fly   454 KQEDAKVMCTVDANPREVEFSWTFNNSAESIDVATNH------------------IIRSG----- 495

  Fly   551 SYVETVSELIYTPKGERDYGTLACYGRNAIGKQSDPCVFQVVPAAKPGALRNCTLRPYVVTSASL 615
                |.|.:.|||..|.|||||.|...|.||||..||||.::.|.:|..:.|||:....:||.::
  Fly   496 ----TTSIVTYTPITELDYGTLLCLASNKIGKQRVPCVFHIIAAGRPEKVHNCTVNNISMTSLTV 556

  Fly   616 NSSNQTTMHANQILPTQYGRHESNYPHMEYVRERHNSSGGNNNGTAP----------AAGRNNVA 670
            ..|:    ..|..||..:        ::|.:.........|...|.|          :..|.|:.
  Fly   557 TCSD----GFNGGLPQSF--------NLELLDSYTQEIKANITSTIPKFTVPGLSPGSIYRLNIY 609

  Fly   671 NKNMRGRT-----SAGQAKSNNKQLTQQQLQRLKKRTSFTP------SQTLAAI----------- 713
            ..|.:||:     :|...:...||||.:|...|:....|:|      ..|||.:
  Fly   610 AFNTKGRSDPAIVNAAMLRMPEKQLTSEQTHNLRAELLFSPVMSLTIGLTLAVLVAVLAIILALR 674

  Fly   714 -----ERQRQRKQLSQQQQQLQQQHHQATATKSGG--------DNKPDGSP--------AKSSKQ 757
                 ..:|::|:||  .:.:.:......:.||.|        :..||..|        |:|.::
  Fly   675 IPCTASSRRRQKELS--NENISRDESPGPSDKSSGSKEVDDCDEKNPDVVPESIEPDEQAESIRK 737

  Fly   758 RMR----RASRDPQ---IQQQQQHQQQQQHQLHAA-----TSITSSQRKQAESNLS------TSH 804
            |.:    ..:|.|.   ...:|||....:..|.|:     .::.|....||:|::.      |.|
  Fly   738 RQQISTIDTNRSPNRGIFVNEQQHLTAAEISLRASHGIGYCTLRSGMHAQAQSSVGEISINVTPH 802

  Fly   805 LGKGSSSSSRSRRSSSSNINSKSN---NGKQPAKYFNKRQKNMHKQKHQQKLKQLKGTTNEHN-S 865
            :...|.|.....|.||.|:.:..|   .|.:|...|           ||....|.:.....|| :
  Fly   803 VYSNSISQCTLPRQSSQNVWNNYNCNITGARPTSTF-----------HQLTFPQGRVNVGGHNPA 856

  Fly   866 NIIHHYAALSSSLRRRKRLAANDILATVAAASTSASLSSP 905
            ..:|.:|...|.       |:|.     :.||::.:|..|
  Fly   857 QPLHGHAPSPSQ-------ASNS-----SMASSTNTLPQP 884

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
side-III	NP_001036681.1	IG_like	59..166	CDD:214653	46/106 (43%)
		V-set	59..166	CDD:284989	46/106 (43%)
		ig	190..268	CDD:278476	20/77 (26%)
		IG_like	192..259	CDD:214653	18/66 (27%)
		Ig	296..361	CDD:299845	20/64 (31%)
		IG_like	391..468	CDD:214653	37/76 (49%)
		IGc2	392..454	CDD:197706	30/61 (49%)
side-VII	NP_001262432.1	IG_like	32..134	CDD:214653	45/102 (44%)
		V-set	32..134	CDD:284989	45/102 (44%)
		IGc2	160..>214	CDD:197706	14/53 (26%)
		Ig	262..328	CDD:299845	21/65 (32%)
		IG_like	264..323	CDD:214653	19/58 (33%)
		IGc2	360..425	CDD:197706	31/64 (48%)
		Ig_3	456..519	CDD:290638	27/89 (30%)
		FN3	538..620	CDD:238020	19/93 (20%)
		FAM176	643..741	CDD:291517	18/99 (18%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	41	1.000	Domainoid score	I12487
eggNOG	1	0.900	-	-		E1_KOG3515
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D23448at33392
OrthoFinder	1	1.000	-	-		FOG0002810
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR23278
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X1676
	7	6.920