DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment side-III and kirre

DIOPT Version :9

Sequence 1:	NP_001036681.1	Gene:	side-III / 4379844	FlyBaseID:	FBgn0083949	Length:	1689	Species:	Drosophila melanogaster
Sequence 2:	NP_001245505.1	Gene:	kirre / 31292	FlyBaseID:	FBgn0028369	Length:	956	Species:	Drosophila melanogaster

Alignment Length:	1049	Identity:	205/1049 - (19%)
Similarity:	319/1049 - (30%)	Gaps:	367/1049 - (34%)

- Green bases have known domain annotations that are detailed below.

  Fly    61 AVLGRTASLPCDIEPEAKDDRVYMVLWFRESAGKPLYSFDVRGRPFEKALYWSDTNSFGPRAYFV 125
            ||:|...:|||.:.     ::|..:.|.::..|                 .....|..|...|.:
  Fly    93 AVVGSRVTLPCRVM-----EKVGALQWTKDDFG-----------------LGQHRNLSGFERYSM 135

  Fly   126 TGQQPA---KLSVDNIQLDDEGVYRCRVDFQNSP-------TRNHRINLTVIVPPHQILVYDASG 180
            .|....   .|.:..:.|||:..|:|:|    .|       .|:....|||:|||.
  Fly   136 VGSDEEGDFSLDIYPLMLDDDAKYQCQV----GPGPQGEQGIRSRFAKLTVLVPPE--------- 187

  Fly   181 RDVAGAVGPLLEGDNIVLT--------CEVRGGRPEPTVTWMNG-----TRTLE-AGSGVSMGRH 231
                  ...:.:||.:|.|        |..:||:|...:||::|     |:.:| ....::..|.
  Fly   188 ------APKITQGDYLVTTEDREIELECVSQGGKPAAEITWIDGLGNVLTKGIEYVKEPLADSRR 246

  Fly   232 VTVNRLEVAQISRSALNNTYRCQASNTKLVAPVERSIRIEMLLKPTSVNLTNKLKV--------- 287
            :|...:......:...|.|:.|||.||     .:|:.|...||  ..|....|:.|
  Fly   247 ITARSILKLAPKKEHHNTTFTCQAQNT-----ADRTYRSAKLL--LEVKYAPKVIVSVVGGALAG 304

  Fly   288 --FASNTQYNLTCIVAGSVPDTEIKWTQNNRPFKRGLLSTSQSNGRVISTLTFYPQPEDDGTMLK 350
              .....:..|:|....:..:...:|..|:.     |::...:...:|..::  .|..|  .::|
  Fly   305 GKIPEGAEVILSCQADANPHELSYRWFINDE-----LMTGDFTTKMIIHNVS--RQYHD--AIVK 360

  Fly   351 CEGSNPRLQNSAI---EDSLMMNVIY-------PPQVTLSLGSTLRPDDIKEGDDVYFECHIKSN 405
            ||..|      |:   |.|..:::.:       |..|...||:|           |...|.:..|
  Fly   361 CEVVN------AVGKSEQSKKLDISFGPVFRQRPVSVEADLGAT-----------VSMRCDVAGN 408

  Fly   406 PKEHRIMWSHDGQPVTQNVSWGIIISTRSLVLQRVGRIHSGFYACSAANDRGETQSAPVNLRIRY 470
            | |..|.|      :::|...  ::...:.:..:|....:|.|.|.|..:......|...|.::.
  Fly   409 P-EPEIEW------ISENSDQ--VVGVAAELKLKVSSETAGRYFCKAVVNGFPEIGAEATLYVKR 464

  Fly   471 APVCSSSSITVIGASLEEDVPIPCRVNSDPPEIDFEWTFSTSGEHFEVPSGHYATIQDPTMTTTS 535
            ||:.:|..:...|..  ..|.|.|...|.|......|:|  .|:...:.|.      ||.:....
  Fly   465 APIITSHKVQFGGVG--GRVKIDCLAFSIPKAEHILWSF--EGKIINMSSA------DPDIYIFE 519

  Fly   536 D------VRRTVV--ESNETHFESYVETV------SELIYTPKGERD--------YGTLAC---- 574
            :      ||..::  :|..|||..|..||      ..|:.|...|..        .|::.|
  Fly   520 EHHLPEGVRAALIIRDSKATHFGKYNCTVMNSYGGDSLVITLLREPGNIPVLLVVMGSMFCVAII 584

  Fly   575 ---------YGRNAIGKQSDPCVFQVVPAAKPGA---------LR------------------NC 603
                     |.:....|:..|.  .|:|.|..|.         ||                  |.
  Fly   585 LMIVMIIIVYRKRRSRKKPMPA--DVIPEASRGGDKLNELKSELRSKAYDVEYSEAGGDGLAINL 647

  Fly   604 TLRP---YVVTSASL------------------------------NSSNQTTMHANQILPTQY-G 634
            |..|   ..:..|:|                              |..||.        .|.| |
  Fly   648 TQSPMPDVQMKGATLGVPLAGPVKFDERFSGDFGGDRYNRQCHIKNLKNQQ--------ETAYKG 704

  Fly   635 RHESN-YPH-MEYVRERHNSSGGNNNGTAPAAGRNNVANKNMRGRTSAGQAKSNNKQLTQQQLQR 697
            ..::| |.| .||..: ::..||  .|.|...|...|......|..||
  Fly   705 SPQANGYAHYFEYALD-YSPPGG--EGAAVVVGSGGVGKLKNGGMNSA----------------- 749

  Fly   698 LKKRTSFTPSQTLAAIERQRQRKQLSQQQQQLQQQHHQATATKSGGDNKPDGSPAKSSKQRMRRA 762
                       ||.                      |.|.||.:||.....|..:
  Fly   750 -----------TLP----------------------HSAAATVNGGGAGNGGGAS---------- 771

  Fly   763 SRDPQIQQQQQHQQQQQHQLHAATSITSSQRKQAESNLSTSHLGKGSSSSSRSRRSSSSNIN--- 824
                 :.:.|:|:.||..|                   |...||:....:....|.|:...|
  Fly   772 -----LPRNQRHEIQQSQQ-------------------SNGFLGQPLLQNGIDSRFSAIYGNPYL 812

  Fly   825 -------------SKSNNGKQPAKYFNKRQKNMHKQKHQQKLKQLKG-----TTNEHNSNIIHHY 871
                         |.:|....||.......::.|.......||...|     |:...|.||....
  Fly   813 RTNSSLLPPLPPPSTANPAATPAPPPYHAARHGHAHHANGGLKHFVGGAVITTSPVGNVNINGGG 877

  Fly   872 AALSSSLRRRKRLAANDILATVAAASTSASLSSPPASSAASLAATATAAVEIEQDVSAVDAPAAD 936
            ...|:.      .....:...|||..:.:..||...:|:.:||||..|...:........:|
  Fly   878 GGGSTP------SGGGGVGVGVAAGGSVSGSSSNLTASSNTLAATPLAGGGVGNSGQCAQSP--- 933

  Fly   937 SG----SNN 941
            ||    |||
  Fly   934 SGQFILSNN 942

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
side-III	NP_001036681.1	IG_like	59..166	CDD:214653	23/114 (20%)
		V-set	59..166	CDD:284989	23/114 (20%)
		ig	190..268	CDD:278476	23/91 (25%)
		IG_like	192..259	CDD:214653	21/80 (26%)
		Ig	296..361	CDD:299845	12/64 (19%)
		IG_like	391..468	CDD:214653	15/76 (20%)
		IGc2	392..454	CDD:197706	13/61 (21%)
kirre	NP_001245505.1	Ig	87..183	CDD:299845	24/115 (21%)
		IG_like	88..182	CDD:214653	23/114 (20%)
		C2-set_2	189..279	CDD:285423	23/94 (24%)
		Ig_2	307..379	CDD:290606	15/86 (17%)
		I-set	382..462	CDD:254352	20/99 (20%)
		IGc2	396..446	CDD:197706	14/69 (20%)
		Ig	466..561	CDD:299845	24/104 (23%)
		IG_like	478..561	CDD:214653	21/92 (23%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	1	0.910