DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment side-III and syg-2

DIOPT Version :9

Sequence 1:	NP_001036681.1	Gene:	side-III / 4379844	FlyBaseID:	FBgn0083949	Length:	1689	Species:	Drosophila melanogaster
Sequence 2:	NP_001309674.1	Gene:	syg-2 / 181561	WormBaseID:	WBGene00007750	Length:	1230	Species:	Caenorhabditis elegans

Alignment Length:	881	Identity:	174/881 - (19%)
Similarity:	314/881 - (35%)	Gaps:	246/881 - (27%)

- Green bases have known domain annotations that are detailed below.

  Fly   132 KLSVDNIQLDDEGVYRC-RVDFQNSPTRNHRINLTVIVPPHQILVYDASGRDVAGAVGPLLEGDN 195
            :|||:..|::.|    | ..:.:.|..:.|.|.  :|.||...::.....|       ...|||.
Worm   398 ELSVEAHQINVE----CMATNPEGSSAKQHVIK--IIAPPKAPIITGLEDR-------KFFEGDI 449

  Fly   196 IVLTCEVRGGRPEPTVTWMNGT-RTLEAGSGVSMGRHVTVNRLEVA----------QISRSALNN 249
            :.:|||.:||.|...::|..|: :.|..|........|.....|||          ::.|:....
Worm   450 VNVTCEAQGGNPLAELSWYRGSEKHLVKGRKKMKWSQVNGAHNEVAGFSSYSTLALRVDRTMNTQ 514

  Fly   250 TYRCQASNTKLVAPVERSIRIEMLLKPTSVNL------TNKLKVFASNTQYNLTCIVAGSVPDTE 308
            ..:|:|:|..|..|:..|..:.:...|..|.:      ..:|.|..|   ..|.|....|.|...
Worm   515 RLKCEATNAALDEPLIESQYLSVYYPPRRVLIRPADSGDQRLLVGKS---ARLVCGTLSSNPAAH 576

  Fly   309 IKW-----TQNNRPF--KRGLLSTSQSNG-RVISTLTFYPQPEDDGTMLKCEGSNPRLQNSAIED 365
            |.|     |.:|:..  ...|..|::.|| .|.:.|:|.|..|.|||::.|..::|..::| :..
Worm   577 ISWQFSRATDDNKVHLGDVSLNETTRDNGFNVENVLSFTPTEEYDGTVVHCIANHPEWKHS-VNT 640

  Fly   366 SLMMNVIYPPQVTLSLGSTLRPDDIKEGDDVYFECHIKSNPKEHRIMWSHDGQPVTQNV----SW 426
            |..:||:|||::.::...|:   .:.|||.......::.||......|..:|.|....:    :.
Worm   641 SFPLNVMYPPKMLVNDPVTV---VMSEGDSFKENLTVRGNPAISLWQWRKNGVPFDHTIGRVFAR 702

  Fly   427 GIIISTRSLVLQRVGRIHSGFYACSAANDRGETQSAPVNLRIRYAPVCSSSSITVIGASLEEDVP 491
            |.::|.:.|:     ...:|.|..:|.|..|.| :..:.|.:.|:...:|.|..||.|: .:.|.
Worm   703 GAVLSGKQLL-----STDAGVYTLTATNSVGST-NITIKLAVEYSARITSISTPVIAAT-GDTVL 760

  Fly   492 IPCRVNSDPPEID-FEW-----------------------TFSTSGEH----------------- 515
            :.|..:.:|.:.: ..|                       |...|||:
Worm   761 LECEADGEPSKANMIHWYKNGEILAAQHRGHKKAILRLNATEQQSGEYTCKADNGIGVPAEGQTF 825

  Fly   516 --------------------------------FEVPSGHYATIQDPTMTTTSDVRRTVVESNETH 548
                                            :.||:..:...:|..:...:..:.::| :.:..
Worm   826 LLVNSAPRVLPVARYAKTAGILGGVAKARCKVYAVPTVEFVWEKDEQLIKKNSSKYSIV-NTQID 889

  Fly   549 FESYVET--VSELI---YTPKGERDYGTLACYGRNAIGKQSDPCVFQVVPAAKPGALRNCTLRPY 608
            :.:|..|  :..::   ||.|       :.|..||:.|  :|.....::|...|....|.|:...
Worm   890 YSTYESTLWIKNIVPDDYTKK-------VKCIARNSFG--TDHLSIPIIPPTHPDEPFNLTMTNS 945

  Fly   609 VVTSASLNSSNQTTMHANQILPTQYGRHESNYPHMEYVRERH---------------------NS 652
            .:.:.|:....:....::||...:|.|...:..|:  |...|                     |:
Worm   946 TLNTISVAWEPRFDGGSDQIFEVKYRRQNDDLIHL--VNTTHTNLRLSGLATANTYFFQIRSINA 1008

  Fly   653 SGGNNNGTAPAAGRNNVANKNMRGRTSAGQAKSNNKQLTQQQLQRLKKRTSFTPSQTLAAI---- 713
            .|..::.|:|..    .|..|..|   ...|...|::|         |.|::.|...:..:
Worm  1009 RGFASSWTSPVI----FATLNEDG---VNVAMIRNEKL---------KLTTWIPYILIFIVLFML 1057

  Fly   714 ----------ERQRQRKQLSQQQQQLQQQHHQATATKSGGDNKP----------DGSPAKSSKQR 758
                      .|.::||        |:::...|....:|||.:.          ||...:....|
Worm  1058 LNVVICCFVCNRTKKRK--------LREKTEMARTAINGGDVRQVQMYGTMMGNDGMSRRDIDDR 1114

  Fly   759 MRRASRDPQIQQQQQ-----HQQQQQHQLHAATSITSSQRKQAESNLST-SHLGKGSSSSSRS-- 815
            ...:..:..::...:     :.|..:..|:.:|.:       .|.:..| |::  |||..:||
Worm  1115 PEMSEDEHSVRTMIEVSPNGYMQPIEPMLYESTGL-------LEYDYQTRSYM--GSSQGTRSMT 1170

  Fly   816 ----------RRSSSSNINS---KSNNGKQPAKYFN 838
                      :.|..||.||   :|||...|..:.:
Worm  1171 YANVPYPEPPQPSYHSNWNSLQRQSNNNTSPQHHLS 1206

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
side-III	NP_001036681.1	IG_like	59..166	CDD:214653	9/34 (26%)
		V-set	59..166	CDD:284989	9/34 (26%)
		ig	190..268	CDD:278476	23/88 (26%)
		IG_like	192..259	CDD:214653	21/77 (27%)
		Ig	296..361	CDD:299845	22/72 (31%)
		IG_like	391..468	CDD:214653	18/80 (23%)
		IGc2	392..454	CDD:197706	14/65 (22%)
syg-2	NP_001309674.1	IG_like	25..105	CDD:214653
		Ig	33..122	CDD:299845
		Ig	147..228	CDD:299845
		IGc2	248..313	CDD:197706
		Ig	450..537	CDD:299845	21/86 (24%)
		Ig	559..632	CDD:299845	22/75 (29%)
		I-set	657..738	CDD:254352	19/89 (21%)
		Ig	665..738	CDD:299845	17/78 (22%)
		IG_like	748..828	CDD:214653	12/80 (15%)
		IGc2	756..817	CDD:197706	8/60 (13%)
		Ig	845..922	CDD:299845	13/86 (15%)
		FN3	934..1023	CDD:238020	15/94 (16%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3515
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.810