DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment stnB and STON2

DIOPT Version :9

Sequence 1:	NP_001036318.2	Gene:	stnB / 4379834	FlyBaseID:	FBgn0016975	Length:	1262	Species:	Drosophila melanogaster
Sequence 2:	NP_001353778.1	Gene:	STON2 / 85439	HGNCID:	30652	Length:	977	Species:	Homo sapiens

Alignment Length:	1137	Identity:	286/1137 - (25%)
Similarity:	450/1137 - (39%)	Gaps:	264/1137 - (23%)

- Green bases have known domain annotations that are detailed below.

  Fly   147 LGRIPATRSPSPVSMRD-----LHSPSPTPD--SGLADLLDVS---------VDSGSSAHTQGIE 195
            |..:.||.....||..:     .||...|.:  .||:...|.|         ||.||..|:...:
Human     4 LDHVIATHQSEWVSFNEEPPFPAHSQGGTEEHLPGLSSSPDQSESSSGENHVVDGGSQDHSHSEQ 68

  Fly   196 AD------LISGVAGGVRLDNPFAVPTAVPNIQAAVPLPATPIKQPPRPPPPRPAPPRPAPPGQA 254
            .|      |||..|                                             :|||
Human    69 DDSSEKMGLISEAA---------------------------------------------SPPG-- 86

  Fly   255 APQRPPPPLAAVNPPPAAPEADDLLDMFGTTACKPAKPPPPKSKEDILSLFEQPHVPLSQPA-SK 318
            :|::|||.||:.        ..:.:.....|......||..::.|..|        ||:.|. :.
Human    87 SPEQPPPDLASA--------ISNWVQFEDDTPWASTSPPHQETAETAL--------PLTMPCWTC 135

  Fly   319 PDLLHDDLDETIGEGEPPEQEEPDTEQSNEISSRDEPVF----TSL-LIRPDESTHDITS----- 373
            |..      :::|.. |...|...|..|.:.||   |.|    |.| ||..:|.|....|
Human   136 PSF------DSLGRC-PLTSESSWTTHSEDTSS---PSFGCSYTDLQLINAEEQTSGQASGADST 190

  Fly   374 --QPQAATGLERQVNNMAAPSGTASTQRATTPDIEITTVEDLP-RSDDEDE-PEAMQEP-ETETK 433
              :.:..||.:..|:.:.|.|...||:   |..::.:.....| ||.:..| ||....| :..:.
Human   191 DKRTEWQTGRQTAVSPVQACSEHTSTR---THRLDPSPPSPQPKRSQNPGEGPEGASAPNDNSSS 252

  Fly   434 PQIEPDTEPEIVS-EHSPPTERLVTQAALVDGELIAAEPEPEEMDTGLDFPLASSGQLSANPFAS 497
            .|.:.:.|.|.:| :.|.|                |....|....|...||          .:.:
Human   253 LQEDEEVEMEAISWQASSP----------------AMNGHPAPPVTSARFP----------SWVT 291

  Fly   498 PDEEEPNFAPMPAAVANIFAVNDPDSQMETPKAPSHTANIFASDPDEFDAFSAKFDSVKKDNISI 562
            .|:.|.: .|:| .|.:....|.|.|....|..|.::...| ...|...:....|..|:|.:||.
Human   292 FDDNEVS-CPLP-PVTSPLKPNTPPSASVIPDVPYNSMGSF-KKRDRPKSTLMNFSKVQKLDISS 353

  Fly   563 MDGFGGSGAITPTGGDAWGGSAFGSTTISANACGDTNSADDGFGNDDDDFYA----MQAPARADS 623
            ::.       ||:..:|   |.:.:|....|     .:..|...:..:.|.|    .:..::..|
Human   354 LNR-------TPSVTEA---SPWRATNPFLN-----ETLQDVQPSPINPFSAFFEEQERRSQNSS 403

  Fly   624 VESV----DKDFSVVIRPMA---EETSGVAPQLAPPPPPARGVNQAQTTSLPGLTVNPFEDVSGF 681
            :.|.    .:|..:||...|   :::|               ..|:.:.::..|.....:|...|
Human   404 ISSTTGKSQRDSLIVIYQDAISFDDSS---------------KTQSHSDAVEKLKQLQIDDPDHF 453

  Fly   682 PAPGLPPTDGTAIKRTDSQDTPQTPLYDEDVSQPLEEFPRLHYIGPGWEMQLRQPNKKKITGQRF 746
            .:..||..|..|....|:.......      |||.:          ||.|.||.|.||.|...|.
Human   454 GSATLPDDDPVAWIELDAHPPGSAR------SQPRD----------GWPMMLRIPEKKNIMSSRH 502

  Fly   747 WKKIVVRLVVQNDVPVVQLLNQAGDKQPFQELPLQPSYSVSEIGAQQYDQFGKIFTMKLQYIFYK 811
            |..|.|:|   .|...:||..:.|.::||:|..|:..:.:||...|.||:.|:|.::::..:.||
Human   503 WGPIFVKL---TDTGYLQLYYEQGLEKPFREFKLEICHEISEPRLQNYDENGRIHSLRIDRVTYK 564

  Fly   812 ERPGVRPGQVTKAERITNKLTKFAQYAIAGDYEGVKEFGSDLKKLGLPVEHAPQSSQLFKIGSMN 876
            |:...:|...                                      |.|..:..|:.|:|:.|
Human   565 EKKKYQPKPA--------------------------------------VAHTAEREQVIKLGTTN 591

  Fly   877 YEDMKQFSVCIEEALFKIPA----LRERALTYKMEEVQVTAVDEIT-VEQDFEGKILKQIARVRL 936
            |:|...|...:::.|..:|.    |....|.|..||:.|...||.: :....:.:||:.....|:
Human   592 YDDFLSFIHAVQDRLMDLPVLSMDLSTVGLNYLEEEITVDVRDEFSGIVSKGDNQILQHHVLTRI 656

  Fly   937 FFLAFLTGMPTIELGVNDMWRQGKEVVGRHDIIPVATEEWIRLEAVEFHSVVNQKEYERTRTIKF 1001
            ..|:||:|:....||:||:..:|.|:|.|.||:|..|.:||:|....||..|::..:..:|.|.|
Human   657 HILSFLSGLAECRLGLNDILVKGNEIVLRQDIMPTTTTKWIKLHECRFHGCVDEDVFHNSRVILF 721

  Fly  1002 QPPDANYIELLRFRVRPPKNRELPLQLKATWCVSGNKVELRADI-LVPGFTSRK--LGQIPCEDV 1063
            .|.||...||:|||. ....:.||..|:....|:|.:||:::.: :..||::.:  |.|:|||:|
Human   722 NPLDACRFELMRFRT-VFAEKTLPFTLRTATSVNGAEVEVQSWLRMSTGFSANRDPLTQVPCENV 785

  Fly  1064 SVRFPIPECWIYLFRVEKHFRYGSVKSAHRRTGKIKGIERILGAVDTLQESLIEVTSGQAKYEHH 1128
            .:|:|:|..|:..||.|......|:|:...| |...|...:.|:     |.::.||.|.|||||.
Human   786 MIRYPVPSEWVKNFRRESVLGEKSLKAKVNR-GASFGSTSVSGS-----EPVMRVTLGTAKYEHA 844

  Fly  1129 HRAIVWRCPRLPKEGQGAYTTHQLVCRMALTSYDQIPSELAPYAFVEFTMPATQVSHTTVRSVSV 1193
            ..:||||..|||.:...:...|...|.:.|.|..::||..|.:..|||:||.|..|..:|||:||
Human   845 FNSIVWRINRLPDKNSASGHPHCFFCHLELGSDREVPSRFANHVNVEFSMPTTSASKASVRSISV 909

  Fly  1194 QDSDGDEPPEKYVRYLARHEYKVGIETTHGES 1225
            :|.   ....|:|.|.|.:.|    :||..::
Human   910 EDK---TDVRKWVNYSAHYSY----QTTETDN 934

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
stnB	NP_001036318.2	Trypan_PARP	377..496	CDD:114603	26/122 (21%)
stnB	NP_001036318.2	AP_MHD_Cterm	897..1219	CDD:299401	113/325 (35%)
STON2	NP_001353778.1	Stonin2_N	1..397	CDD:314830	108/512 (21%)
STON2	NP_001353778.1	AP_stonin-2_MHD	616..928	CDD:271169	113/325 (35%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	184	1.000	Domainoid score	I3417
eggNOG	1	0.900	-	-		E1_KOG2677
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0006875
OrthoInspector	1	1.000	-	-		otm41043
orthoMCL	1	0.900	-	-		OOG6_108692
Panther	1	1.100	-	-	LDO	PTHR10529
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R1533
SonicParanoid	1	1.000	-	-		X2217
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	10	9.840