DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment stnB and Ston1

DIOPT Version :9

Sequence 1:	NP_001036318.2	Gene:	stnB / 4379834	FlyBaseID:	FBgn0016975	Length:	1262	Species:	Drosophila melanogaster
Sequence 2:	NP_084134.2	Gene:	Ston1 / 77057	MGIID:	1924307	Length:	730	Species:	Mus musculus

Alignment Length:	699	Identity:	174/699 - (24%)
Similarity:	283/699 - (40%)	Gaps:	146/699 - (20%)

- Green bases have known domain annotations that are detailed below.

  Fly   611 DFYAMQAPARADSVESVDKDF----------SVVIRPMAEETSGVAPQLA----PP--------- 652
            |||....|.....:.:..|||          :.|:.|:.|.:|..||..|    ||
Mouse    68 DFYFSPGPPSNSPLSTPTKDFPGFPGIPKAGTHVLYPIPECSSSSAPTTAGGVGPPLLLTKPDCS 132

  Fly   653 -------------PPPARGVNQ---AQTTSLPGLTVNPFEDVSGFPAP-------GLP-PTDGTA 693
                         |.|..|..:   .|...........|:|...|..|       ..| |.|..|
Mouse   133 PHVSLPSSHSHTQPTPTLGFTEDAGPQRVQSEARQFEYFQDHCAFSNPFWKDEGSASPFPLDSLA 197

  Fly   694 IKRTDSQDTPQTPLYDEDVSQ-----PLEEFPRLH----------------YIG----------- 726
            .::..|....:.|:..:.::|     ..|:...||                |.|
Mouse   198 SRKPFSPKDKEVPIGHKSLTQCSLDYICEKLEHLHSAETQDPLGDLSMQDPYAGDTVSFVPHSLF 262

  Fly   727 -----PGWEMQLRQPNKKKITGQRFWKKIVVRLVVQNDVPVVQLLNQAGDKQPFQELPLQPSYSV 786
                 .||...||.|.||.:...|.|..|.::::...   ::|:..:.|.::||:|..|.|...:
Mouse   263 RSQPRAGWSFMLRIPEKKNMMSSRQWGPIFLKVLPGG---ILQMYYEKGLEKPFKEFQLDPHCRL 324

  Fly   787 SEIGAQQYDQFGKIFTMKLQYIFYKERPGVRPGQVTKAERITNKLTKFAQYAIAGDYEGVKEFGS 851
            ||...:.:...|||.|:|::::.|.|:                           ..|....|
Mouse   325 SEPKLENFSMAGKIHTVKVEHVSYSEK---------------------------RKYHAKTE--- 359

  Fly   852 DLKKLGLPVEHAPQSSQLFKIGSMNYEDMKQFSVCIEEALFKIPA-LRERALTYKMEEVQVTAVD 915
                    |.|.|:..|:.|:||..:.|..:|...:||.|.|:|| .:.:..:|:.:|:.:...|
Mouse   360 --------VVHEPEVEQMLKLGSTEHRDFLEFLTTVEEELIKLPATAKPKNKSYEEQEICLDIQD 416

  Fly   916 EITVEQDFEGKILKQIARVRLFFLAFLTGMPTIELGVNDMWRQGKEVVGRHDII--PVATEEWIR 978
            .:..:...||::::.....::..|.||.|.....|.:||     :|:..|.:..  ....::.|.
Mouse   417 SLWGKVTKEGQLVESAVVTQICCLCFLNGPAECFLALND-----RELQKRDECYFEKEPEKKGIA 476

  Fly   979 LEAVEFHSVVNQKEYERTRTIKFQPPDANYIELLRFRVRPPKNRELPLQLKATWCVSGNKVELRA 1043
            :....||:.|..:|:|::|.|||.|.||...||:||:...... |||..:|:...|.|..|||:|
Mouse   477 ILDYHFHTCVKAEEFEQSRIIKFVPLDACRFELMRFKTSYEAG-ELPFAVKSVVTVQGAYVELQA 540

  Fly  1044 DI-LVPGFT-SRKLGQI-PCEDVSVRFPIPECWIYLFRVEKHFRYGSVKSAHRRTGKIKGIERIL 1105
            .: :.|... |...|.: .|.::.:.||:|..||.........|..|:|:...|...:..::
Mouse   541 FVNMTPAAQGSPHAGALRSCNNIMIHFPVPAQWIKALWTRNLQRQKSLKAKMNRRACLGSLQ--- 602

  Fly  1106 GAVDTLQESLIEVTSGQAKYEHHHRAIVWRCPRLPKEGQGAYTTHQLVCRMALTSYDQIPSELAP 1170
               :...|.:|:||.|.||||..:||:||:..|||.:.......|.|..::.|.|..::||:..|
Mouse   603 ---EPESEPVIQVTVGSAKYESAYRAVVWKIDRLPDKNSSPDQPHCLSYKLELGSDQEVPSDWYP 664

  Fly  1171 YAFVEFTMPATQVSHTTVRSVSVQDSDGDEPPEKYVRYLARHEYKVGIE 1219
            :|.|:|:|.....|.|.|||:.|   :.|..|:|:|...|.:..:|.||
Mouse   665 FATVQFSMLEACASRTEVRSLGV---ESDAQPQKHVCQRACYNIQVEIE 710

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
stnB	NP_001036318.2	Trypan_PARP	377..496	CDD:114603
stnB	NP_001036318.2	AP_MHD_Cterm	897..1219	CDD:299401	93/326 (29%)
Ston1	NP_084134.2	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..26
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	38..83		4/14 (29%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	132..159		3/26 (12%)
		AP_MHD_Cterm	397..711	CDD:385861	95/329 (29%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	190	1.000	Domainoid score	I3271
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	289	1.000	Inparanoid score	I2794
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	1	1.000	-	-		otm43113
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR10529
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R1533
SonicParanoid	1	1.000	-	-		X2217
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	8	8.090