DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment stnB and gtf2a1

DIOPT Version :9

Sequence 1:	NP_001036318.2	Gene:	stnB / 4379834	FlyBaseID:	FBgn0016975	Length:	1262	Species:	Drosophila melanogaster
Sequence 2:	XP_031746336.1	Gene:	gtf2a1 / 549662	XenbaseID:	XB-GENE-1006404	Length:	1223	Species:	Xenopus tropicalis

Alignment Length:	977	Identity:	228/977 - (23%)
Similarity:	395/977 - (40%)	Gaps:	252/977 - (25%)

- Green bases have known domain annotations that are detailed below.

  Fly   343 TEQSNEISSRDEPVFTSLLIRPDESTHDITSQPQAATGLERQVNNMAAPSGTASTQRATTPDIEI 407
            |::|:.:|..|:.:... ..:.|:|:|
Frog     7 TQKSDWVSFNDDLILQG-AAKQDQSSH-------------------------------------- 32

  Fly   408 TTVEDLPR--SDDEDEPEAMQEPETETKPQIEPDTEPEIVSEHSPPTERLVTQAALVDGELIAAE 470
                 ||.  ||.|....::   .:.::.:|:|.....:||:|         ..||.|...:.
Frog    33 -----LPNKFSDQEKSHLSL---HSSSENEIKPTEADHMVSDH---------VNALQDHLNLG-- 78

  Fly   471 PEPEEMDTGLDF-----PLASSGQLSANPFASPD----EEEPN-FAPMPA-----------AVAN 514
                 :.|.:.|     |:......:.:...:||    ::.|: .:|:|:           ::.:
Frog    79 -----LSTWVQFEESLPPVPKENAKTESSVGAPDQRWFDQNPSGRSPLPSQSSSEVYVEDISIVS 138

  Fly   515 IFAVNDPDSQMETPKAPSHTANIFASDPDEFDAFSAKFDSVKKDNISIMDGFGGSGAITPTGGDA 579
            |....||.| ::|..|||..|:...|..:.        .|.::|....|:..|
Frog   139 IGPQTDPCS-IQTDDAPSEIASGTGSADNS--------SSFQEDEDLDMENLG------------ 182

  Fly   580 WGGSAFGSTTISANACGDTNSADDGFGNDDDDFYAMQAPARADSVESVDKDFSVVIRPMAEETSG 644
            |..::|   ||:.:....|.|....:...:|:.    ||::.||.:.:.:..:..::......|.
Frog   183 WPVNSF---TINGHTDSPTKSKFPNWVTFEDEI----APSQKDSTQKLLESPTSTLKKRERPKSS 240

  Fly   645 VAPQLAPPPPPARGVNQAQTTSLPGLTVNPFEDVS---GFPAPGLP------------------- 687
            :.............:::..:.:.|....|||.|.:   ..|:|..|
Frog   241 LVDFQRTQRLDFTSLHRQSSLNSPPTKTNPFHDETLKHVLPSPINPFSSYFEKQEKRSQCSSVSS 305

  Fly   688 ----------------------------PTDGTAIK-----RTDSQDTPQTPLYDEDVSQPLEEF 719
                                        .....|::     |.:..|:|.:|...:|   ||::.
Frog   306 DQESCQINFTSLLSEELDTEQFEDYRKKSLQADAVECLKQIRLEDPDSPGSPTLPDD---PLKDD 367

  Fly   720 P----RLHYIGP----GWEMQLRQPNKKKITGQRFWKKIVVRLVVQNDVPVVQLLNQAGDKQPFQ 776
            .    .|.:..|    ||.|.||.|.||.|...|.|..|.|::   .:..::||..:.|.::||:
Frog   368 DSIGISLSFTKPQPEDGWPMMLRIPEKKNIMSSRHWGPIYVKV---TESGMLQLFYEKGLEKPFR 429

  Fly   777 ELPLQPSYSVSEIGAQQYDQFGKIFTMKLQYIFYKERPGVRPGQVTKAERITNKLTKFAQYAIAG 841
            |..|:.::.:.|...|.||:.|:|.|:::..:.|:|:...:|
Frog   430 EYKLEQNHEILEPKLQNYDENGRIHTVRIDKVIYREKRKYQP----------------------- 471

  Fly   842 DYEGVKEFGSDLKKLGLP-VEHAPQSSQLFKIGSMNYEDMKQFSVCIEEALFKIPALRERAL--- 902
                            :| |.|..:..|:.|:|:.:|.|.......|::.||.:|...:.:.
Frog   472 ----------------MPLVTHTGEREQVVKLGTTDYSDFISMIANIQDILFMLPVTIDLSTVHQ 520

  Fly   903 TYKMEEVQVTAVDEITVEQDFEG-------KILKQIARVRLFFLAFLTGMPTIELGVNDMWRQGK 960
            .|..||:.|...||      |.|       |::.......::.|:|::||....:|:||:..:|.
Frog   521 NYTEEEITVDVRDE------FHGIVGKGDNKLIFHSVVTHIYILSFISGMADCRMGLNDILIKGN 579

  Fly   961 EVVGRHDIIPVATEEWIRLEAVEFHSVVNQKEYERTRTIKFQPPDANYIELLRFRVRPPKNRELP 1025
            |||.|:||:|..|.:|::|...:||:.|.:|.:..:|.:.|.|.||...||:|||. ....:.||
Frog   580 EVVARNDIMPTTTTKWVQLHECKFHATVEEKMFHSSRMVVFTPLDACKFELMRFRT-VFSEKTLP 643

  Fly  1026 LQLKATWCVSGNKVELRADILV-PGFTSRK--LGQIPCEDVSVRFPIPECWIYLFRVEKHFRYGS 1087
            ..|:...||.|.:|:|::.::: .||:|.:  |.|:|||:|::|.|:|..|:..||.:......|
Frog   644 FTLRTAVCVRGAEVQLQSWLVMSTGFSSNRDNLSQVPCENVTIRHPVPAEWVNYFRRDSMLGERS 708

  Fly  1088 VKSAHRRTGKIKGIERILGAVDTLQESLIEVTSGQAKYEHHHRAIVWRCPRLPKEGQGAYTTHQL 1152
            :|:...|.... |...:.|:     |..:.||.|.||||:.:.|:|||..|||.:..|....|..
Frog   709 LKAKINREASF-GSPGLSGS-----EPAMRVTLGTAKYENAYNAVVWRINRLPDKNSGWNHPHCF 767

  Fly  1153 VCRMALTSYDQIPSELAPYAFVEFTMPATQVSHTTVRSVSVQDSDGDEPPEKYVRYLARHEYKVG 1217
            .|.:.|.|..:||....||..|||.|||...|...|||:||::::.   .:|:|.|.|.:.|||.
Frog   768 YCHLELGSDREIPQSFVPYVEVEFDMPAASASKVAVRSLSVEENNS---VKKWVNYSAHYFYKVE 829

  Fly  1218 IE 1219
            ||
Frog   830 IE 831

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
stnB	NP_001036318.2	Trypan_PARP	377..496	CDD:114603	16/125 (13%)
stnB	NP_001036318.2	AP_MHD_Cterm	897..1219	CDD:299401	112/334 (34%)
gtf2a1	XP_031746336.1	Stonin2_N	1..296	CDD:403289	62/379 (16%)
		AP_MHD_Cterm	515..832	CDD:416027	114/333 (34%)
		TFIIA	869..1223	CDD:397322
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R1533
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	1.030