DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment stnB and Ston1

DIOPT Version :9

Sequence 1:	NP_001036318.2	Gene:	stnB / 4379834	FlyBaseID:	FBgn0016975	Length:	1262	Species:	Drosophila melanogaster
Sequence 2:	NP_891999.2	Gene:	Ston1 / 360202	RGDID:	727878	Length:	731	Species:	Rattus norvegicus

Alignment Length:	788	Identity:	200/788 - (25%)
Similarity:	313/788 - (39%)	Gaps:	201/788 - (25%)

- Green bases have known domain annotations that are detailed below.

  Fly   545 FDAFSAKFDSVKKDNISIMDGFGGSGAITPTG--GDAWG-------GSAFGSTTISANACGDTNS 600
            ||..|....|.||.::|:..    .|...|.|  .|..|       .|:.|||.:|:...
  Rat    12 FDDDSLFQSSPKKKDLSLET----QGVCRPNGLKLDLPGLRDLPNTPSSTGSTPLSSPMV----- 67

  Fly   601 ADDGFGNDDDDFYAMQAPARADSVESVDKDF----------SVVIRPMAEETS--------GVAP 647
                      |||....|.....:.:..|||          :.|:.|:.|.:|        |..|
  Rat    68 ----------DFYFSPGPPSNSPLSTPTKDFPGFPGIPKAGTHVLYPIPECSSSGPPTTAGGAGP 122

  Fly   648 QLAPPPPPA-------RGVNQAQTTSLPGLT--VNP------------FEDVSGFPAP------- 684
            .|:...|..       .|.:..|.|...|||  .:|            |:|...|..|
  Rat   123 PLSLTKPTCSPHVSLPSGHSHTQLTPTAGLTEDASPRGVQSEARQFEYFQDDCAFSNPFWKDEGG 187

  Fly   685 -GLPPTDGTAIKRTDSQDTPQTP--------------------LYDEDVSQPLEEFP-RLHYIG- 726
             ...|.|..|.::..|....:.|                    |...:...||.... :..|.|
  Rat   188 NSQFPFDSLASRKLFSPRDKEVPDDQKSLNQCSLNYICEKLEHLQSAETQDPLGNLSMQSSYAGG 252

  Fly   727 ---------------PGWEMQLRQPNKKKITGQRFWKKIVVRLVVQNDVPVVQLLNQAGDKQPFQ 776
                           .||...||.|.||.:...|.|..|.::::...   ::|:..:.|.::||:
  Rat   253 TFSFVPHTLFRSQPKAGWSFMLRIPEKKNMMSSRQWGPIFLKVLPGG---ILQMYYEKGLEKPFK 314

  Fly   777 ELPLQPSYSVSEIGAQQYDQFGKIFTMKLQYIFYKERPGVRPGQVTKAERITNKLTKFAQYAIAG 841
            |..|.|...:||...:.:...|||.|:|::::.|.|:
  Rat   315 EFQLNPHCRLSEPKLENFSMAGKIHTVKVEHVSYSEK---------------------------- 351

  Fly   842 DYEGVKEFGSDLKKLGLPVEHAPQSSQLFKIGSMNYEDMKQFSVCIEEALFKIPA-LRERALTYK 905
                 :::.|.::     |.|.|:..|:.|:||..:.|..:|...:||.|.|:|| .:.:...|:
  Rat   352 -----RKYHSKVE-----VVHEPEVEQMLKLGSTEHRDFLEFLTTVEEELVKLPATAKPKNKIYE 406

  Fly   906 MEEVQVTAVD----EITVEQDFEGKILKQIARVRLFFLAFLTGMPTIELGVNDMWRQGKEVVGRH 966
            .:|:.:..:|    ::|.|   |||:::.....::..|.||.|.....|.:||:..|.::
  Rat   407 EQEIHLDILDSFWGKVTKE---EGKLVESAVLTQVCCLCFLNGPAECFLALNDLELQKRD----- 463

  Fly   967 DIIPVATEEWIRLEA---------VEFHSVVNQKEYERTRTIKFQPPDANYIELLRFRVRPPKNR 1022
                   |.:...|.         ..||:.||.:|:||:|.|||.||||...||:|||. ..:..
  Rat   464 -------ERYFEKEPEKRGIDILNYHFHTCVNAEEFERSRIIKFVPPDACRFELMRFRT-SSEGD 520

  Fly  1023 ELPLQLKATWCVSGNKVELRADI-LVPGF-TSRKLGQI-PCEDVSVRFPIPECWIYLFRVEKHFR 1084
            |||..:|:...|.|..|||:|.: :.|.. .|...|.: .|.::.:.||:|..||.........|
  Rat   521 ELPFSVKSIVTVQGAYVELQAFVNMTPAVQRSPHAGSLRSCNNIMIHFPVPAQWIKALWTRNLQR 585

  Fly  1085 YGSVKSAHRR---TGKIKGIERILGAVDTLQESLIEVTSGQAKYEHHHRAIVWRCPRLPKEGQGA 1146
            ..|:|:...|   .|.::|.|         .|.:|:||.|.||||..:||:||:..|||.:....
  Rat   586 QKSLKAKMNRRACLGSLQGPE---------LEPVIQVTVGSAKYESAYRAVVWKIDRLPDKNTSP 641

  Fly  1147 YTTHQLVCRMALTSYDQIPSELAPYAFVEFTMPATQVSHTTVRSVSVQDSDGDEPPEKYVRYLAR 1211
            ...|.|..::.|.|..::||:..|:|.|:|:|.....|.|.|||:.|   :.|..|:|:|...|.
  Rat   642 DQPHCLSYKLELGSDQEVPSDWDPFATVQFSMSEACASRTEVRSLGV---ESDAQPQKHVCQRAC 703

  Fly  1212 HEYKVGIE 1219
            :..:|.||
  Rat   704 YNIQVEIE 711

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
stnB	NP_001036318.2	Trypan_PARP	377..496	CDD:114603
stnB	NP_001036318.2	AP_MHD_Cterm	897..1219	CDD:299401	103/340 (30%)
Ston1	NP_891999.2	AP_MHD_Cterm	397..712	CDD:299401	105/343 (31%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	187	1.000	Domainoid score	I3240
eggNOG	1	0.900	-	-		E1_KOG2677
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	1	1.000	-	-		otm45178
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR10529
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X2217
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	8	7.910