DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment stnB and Ston2

DIOPT Version :9

Sequence 1:	NP_001036318.2	Gene:	stnB / 4379834	FlyBaseID:	FBgn0016975	Length:	1262	Species:	Drosophila melanogaster
Sequence 2:	NP_001129346.1	Gene:	Ston2 / 314349	RGDID:	1311502	Length:	895	Species:	Rattus norvegicus

Alignment Length:	973	Identity:	256/973 - (26%)
Similarity:	393/973 - (40%)	Gaps:	235/973 - (24%)

- Green bases have known domain annotations that are detailed below.

  Fly   320 DLLH---DDLDETIG----EGEP---PEQEEPDTEQ--SNEISSRDEPVFTSLLIRPDESTHDIT 372
            ||.|   ||..|.:|    ...|   |.|..||...  ||.:...|:..:::            |
  Rat    62 DLSHSEQDDSSEKMGLISEAASPPGSPVQPTPDLASAISNWVQFEDDTPWSN------------T 114

  Fly   373 SQPQAATGLERQVNNMAAP--------------SGTASTQRATTP-------DIEITTVED---- 412
            |.|...|.|...|.....|              |.|..::..::|       |:::...|:
  Rat   115 SAPHKETALTLTVPCWTCPSLDSLRRCPLASESSWTTHSEDTSSPSVAPSYTDLQLINAEEQASG 179

  Fly   413 -LPRSDDEDEPEAMQEPETETKPQIEPDT------EPEIVSEHSPP---TERLVTQAALVDGELI 467
             ...:|..|...::||.|     ::|.:|      .|.:....:.|   |.|..:.....|.|:.
  Rat   180 RASGTDSTDNSSSLQEDE-----EVEMETISWWAGSPAMNGHPAVPQVTTARFPSWVTFEDNEVG 239

  Fly   468 AAEP---------EPEEMDTGLDFPLASSGQLSANPFASPDEEEPNFAPMPAAVANIFAVNDPDS 523
            ...|         .|.....|.|.|..|:|....:   .|.....|.:.:..  .:|.::|.|.|
  Rat   240 CPSPTVPSPKKPNAPSAATAGPDVPFNSTGSFKRD---RPKSTLMNLSKVQK--LDISSLNRPPS 299

  Fly   524 QMETPKAPSHTANIFASD------PDEFDAFSAKFDSVKKDNISIMDGFGGSGAITPTGGDAWGG 582
            ..|.|  |....|.|.::      |...:.|||.|:..::.:        .:.:|:.|.|.:...
  Rat   300 VTEAP--PWRATNPFLNESLQDIQPSPINPFSAFFEEQERRS--------QNSSISGTSGKSQRD 354

  Fly   583 SAFGSTTISANACGDTNSADDGFGNDDDDFYAMQAPARADSVESVDKDFSVVIRPMAEETSGVAP 647
            |..   .|..:|.    |.||          :.::.:..|::|.:.:                 .
  Rat   355 SLI---VIYQDAI----SFDD----------SGKSQSHPDAIEKLKQ-----------------L 385

  Fly   648 QLAPPPPPARGVNQAQTTSLPGLTVNPFEDVSGFPAPGLPPTDGTAIKRTDSQDTPQTPLYDEDV 712
            |:..|.|    |..|                      .||..|.||      ...|..|.....:
  Rat   386 QIDDPDP----VGNA----------------------ALPDDDPTA------SVEPDAPSPTSAL 418

  Fly   713 SQPLEEFPRLHYIGPGWEMQLRQPNKKKITGQRFWKKIVVRLVVQNDVPVVQLLNQAGDKQPFQE 777
            |||.:          ||.|.||.|.||.|...|.|..|.::|   .|...:||..:.|.::||:|
  Rat   419 SQPRD----------GWPMMLRIPEKKNIMSSRHWGPIYIKL---TDSGYLQLYYEQGLEKPFRE 470

  Fly   778 LPLQPSYSVSEIGAQQYDQFGKIFTMKLQYIFYKERPGVRPGQVTKAERITNKLTKFAQYAIAGD 842
            ..|:..:.|||...|.||:.|:|.::::..:.|||:...:|...
  Rat   471 FKLEICHEVSEPRLQNYDENGRIHSLRIDRVTYKEKKKYQPKPA--------------------- 514

  Fly   843 YEGVKEFGSDLKKLGLPVEHAPQSSQLFKIGSMNYEDMKQFSVCIEEALFKIPA----LRERALT 903
                             |.||.:..|:.|:|:.||:|...|...:::.|..:|.    |....|.
  Rat   515 -----------------VAHAAEREQVIKLGTTNYDDFLSFIHAVQDRLMDLPVQSMDLSTVGLN 562

  Fly   904 YKMEEVQVTAVDEI--TVEQDFEGKILKQIARVRLFFLAFLTGMPTIELGVNDMWRQGKEVVGRH 966
            |..||:.|...||.  ||.:. :.:||:.....|:..|:||:|:....||:||:..:|.|:|.|.
  Rat   563 YLEEEITVDIRDEFSGTVSKG-DNQILQHHVLTRIHILSFLSGLAECRLGLNDILIKGNEIVSRQ 626

  Fly   967 DIIPVATEEWIRLEAVEFHSVVNQKEYERTRTIKFQPPDANYIELLRFRVRPPKNRELPLQLKAT 1031
            ||:|..|.:||:|....||..|::..:..:|.|.|.|.||...||:|||. ....:.||..|:..
  Rat   627 DIMPTTTTKWIKLHECRFHGCVDEDVFNSSRVILFNPLDACRFELMRFRT-VFAEKTLPFTLRTA 690

  Fly  1032 WCVSGNKVELRADI-LVPGFTSRK--LGQIPCEDVSVRFPIPECWIYLFRVEKHFRYGSVKSAHR 1093
            ..::|.:||:::.: :.|||:|.:  |.|:|||:|.||:|:|..|:..||.|......|:|:...
  Rat   691 ASINGAEVEVQSWLRMSPGFSSNRDPLTQVPCENVMVRYPVPSEWVKNFRRESVLGEKSLKAKVN 755

  Fly  1094 RTGKIKGIERILGAVDTLQESLIEVTSGQAKYEHHHRAIVWRCPRLPKEGQGAYTTHQLVCRMAL 1158
            | |...|.....|:     |.::.||.|.|||||...:||||..|||.:...:...|...|.:.|
  Rat   756 R-GASFGSAGASGS-----EPVMRVTLGTAKYEHAFNSIVWRINRLPDKNSASGHPHCFFCHLEL 814

  Fly  1159 TSYDQIPSELAPYAFVEFTMPATQVSHTTVRSVSVQDSDGDEPPE--KYVRYLARHEYKVGIE 1219
            .|..::||..|.:..|||:||.|..|...|||:||:|.     |:  |:|.|.|.:.|||.||
  Rat   815 GSDREVPSRFANHVNVEFSMPTTSASKAAVRSISVEDK-----PDVRKWVNYSAHYSYKVEIE 872

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
stnB	NP_001036318.2	Trypan_PARP	377..496	CDD:114603	29/162 (18%)
stnB	NP_001036318.2	AP_MHD_Cterm	897..1219	CDD:299401	120/328 (37%)
Ston2	NP_001129346.1	Stonin2_N	1..337	CDD:288839	63/298 (21%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	10..101		12/38 (32%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	144..204		11/64 (17%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	236..279		9/45 (20%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	291..326		10/36 (28%)
		NPF 1	310..312		1/1 (100%)
		NPF 2	326..328		0/1 (0%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	386..424		15/79 (19%)
		AP_stonin-2_MHD	556..873	CDD:271169	122/330 (37%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	187	1.000	Domainoid score	I3240
eggNOG	1	0.900	-	-		E1_KOG2677
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0006875
OrthoInspector	1	1.000	-	-		otm45178
orthoMCL	1	0.900	-	-		OOG6_108692
Panther	1	1.100	-	-	LDO	PTHR10529
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X2217
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
	11	10.770