DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment RunxA and Runx1

DIOPT Version :9

Sequence 1:	NP_001259747.1	Gene:	RunxA / 4379817	FlyBaseID:	FBgn0083981	Length:	663	Species:	Drosophila melanogaster
Sequence 2:	XP_017453542.1	Gene:	Runx1 / 50662	RGDID:	2283	Length:	464	Species:	Rattus norvegicus

Alignment Length:	473	Identity:	172/473 - (36%)
Similarity:	220/473 - (46%)	Gaps:	131/473 - (27%)

- Green bases have known domain annotations that are detailed below.

  Fly    57 SNTEQNTPPTPA---QLLNEAY------------TKMTSDILAERTLGDFLTEHPGELIRTSSPL 106
            |.:.:.|||:.|   ..::||.            :|:.|   .:|::.:.|.:|||||:||.||.
  Rat    22 STSRRFTPPSTALSPGKMSEALPLGAPDGGAALASKLRS---GDRSMVEVLADHPGELVRTDSPN 83

  Fly   107 FVCTVLPPHWRSNKTLPVAFKVVSLGDIMDGTMVTVRAGNDENYCAELRNCTAVMKNQVAKFNDL 171
            |:|:|||.|||.|||||:|||||:|||:.|||:|||.|||||||.|||||.||.||||||:||||
  Rat    84 FLCSVLPTHWRCNKTLPIAFKVVALGDVPDGTLVTVMAGNDENYSAELRNATAAMKNQVARFNDL 148

  Fly   172 RFVGRSGRGKSFTLTITVSTNPPHIATYNKAIKVTVDGPREPRSKTMLSLLGQQQQFHFAFGQR- 235
            ||||||||||||||||||.||||.:|||::|||:||||||||| :....|..|.:....:|.:|
  Rat   149 RFVGRSGRGKSFTLTITVFTNPPQVATYHRAIKITVDGPREPR-RHRQKLDDQTKPGSLSFSERL 212

  Fly   236 --------------PFHFSTDP--------LSGFRMPPIGNCQSASNTH----WGYGSAASAYSP 274
                          |.|.:..|        .:.|...|....|.|....    |.|..:..
  Rat   213 SELEQLRRTAMRVSPHHPAPTPNPRASLNHSTAFNPQPQSQMQDARQIQPSPPWSYDQSYQ---- 273

  Fly   275 YLASSGLSSCTTPTSAQFNNPALGFTCSSNDQSNNQDFGGATNRDCVPMLPDSTASDL----DQH 335
            ||.|  ::|...|.:......|.|.|..|.:.|:..                |||.||    |..
  Rat   274 YLGS--ITSSVHPATPISPGRASGMTSLSAELSSRL----------------STAPDLTAFGDPR 320

  Fly   336 LSSLVGSTSGQMTHHSLLGAGGQTSISSTVNGASGGGSAGAGTAGGGAGSGGGAGGGAGGNSILV 400
            ....:.|.|....|:                       .||.|......||.|.|..|..::
  Rat   321 QFPTLPSISDPRMHY-----------------------PGAFTYSPPVTSGIGIGMSAMSST--- 359

  Fly   401 PRYHTNASNEYNVHSSQNGPRSLSDSSQAES-PVQEDLLTTNTPN----LGSTAGGGAAN--GGA 458
            .||||..            |.....||||:: |.|     |.:|:    .|::||....:  ||.
  Rat   360 SRYHTYL------------PPPYPGSSQAQAGPFQ-----TGSPSYHLYYGTSAGSYQFSMVGGE 407

  Fly   459 GS---------NAGSGAA 467
            .|         ||.:|||
  Rat   408 RSPPRILPPCTNASTGAA 425

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
RunxA	NP_001259747.1	Runt	95..216	CDD:279225	97/120 (81%)
Runx1	XP_017453542.1	Runt	68..194	CDD:395684	98/126 (78%)
Runx1	XP_017453542.1	RunxI	374..464	CDD:400691	18/57 (32%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	212	1.000	Domainoid score	I2685
eggNOG	1	0.900	-	-		E1_KOG3982
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000993
OrthoInspector	1	1.000	-	-		mtm8944
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR11950
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X738
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
	9	8.870