DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment RunxA and Runx2

DIOPT Version :9

Sequence 1:NP_001259747.1 Gene:RunxA / 4379817 FlyBaseID:FBgn0083981 Length:663 Species:Drosophila melanogaster
Sequence 2:XP_038939882.1 Gene:Runx2 / 367218 RGDID:2282 Length:652 Species:Rattus norvegicus


Alignment Length:286 Identity:131/286 - (45%)
Similarity:160/286 - (55%) Gaps:65/286 - (22%)


- Green bases have known domain annotations that are detailed below.


  Fly    86 RTLGDFLTEHPGELIRTSSPLFVCTVLPPHWRSNKTLPVAFKVVSLGDIMDGTMVTVRAGNDENY 150
            ||:.:.:.:||.||:||.||.|:|:|||.|||.|||||||||||:||::.|||:|||.|||||||
  Rat   212 RTMVEIIADHPAELVRTDSPNFLCSVLPSHWRCNKTLPVAFKVVALGEVPDGTVVTVMAGNDENY 276

  Fly   151 CAELRNCTAVMKNQVAKFNDLRFVGRSGRGKSFTLTITVSTNPPHIATYNKAIKVTVDGPREPR- 214
            .|||||.:||||||||:||||||||||||||||||||||.||||.:|||::||||||||||||| 
  Rat   277 SAELRNASAVMKNQVARFNDLRFVGRSGRGKSFTLTITVFTNPPQVATYHRAIKVTVDGPREPRR 341

  Fly   215 -------SK-----TMLSLLGQ-----------QQQFHFAFGQRPFHFS-------TDPLSGFRM 249
                   ||     ..||.||:           .|....:....|..|:       |||.     
  Rat   342 HRQKLDDSKPSLFSDRLSDLGRIPHPSMRVGVPPQNPRPSLNSAPSPFNPQGQSQITDPR----- 401

  Fly   250 PPIGNCQSASNTHWGYGSAASAYSPYLASSGLSSCTTPTSAQFNN--PALGFTCSSNDQSNNQDF 312
                  |:.|:..|.|..:..:|...:.|..:.| |||.|:....  ||:               
  Rat   402 ------QTQSSPPWSYDQSYPSYLSQMTSPSIHS-TTPLSSTRGTGLPAI--------------- 444

  Fly   313 GGATNRDCVPMLPDSTASDLDQHLSS 338
                 .|....:.||..|.||...|:
  Rat   445 -----TDVPRRISDSEPSTLDSQSST 465

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
RunxANP_001259747.1 Runt 95..216 CDD:279225 97/128 (76%)
Runx2XP_038939882.1 Runt 217..343 CDD:395684 97/125 (78%)
PHA03247 <319..606 CDD:223021 50/179 (28%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E1_KOG3982
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 1 1.000 - - FOG0000993
OrthoInspector 1 1.000 - - mtm8944
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 1 1.000 - -
TreeFam 1 0.960 - -
65.770

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