DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment RunxA and run

DIOPT Version :9

Sequence 1:	NP_001259747.1	Gene:	RunxA / 4379817	FlyBaseID:	FBgn0083981	Length:	663	Species:	Drosophila melanogaster
Sequence 2:	NP_001285501.1	Gene:	run / 33059	FlyBaseID:	FBgn0003300	Length:	510	Species:	Drosophila melanogaster

Alignment Length:	469	Identity:	161/469 - (34%)
Similarity:	223/469 - (47%)	Gaps:	123/469 - (26%)

- Green bases have known domain annotations that are detailed below.

  Fly     7 SSNSTASNA-NNNNNNTANNNNTSSNNNTTNTNGSSNNNTSGNNNNSSGNNSNTEQNTPPTPAQL 70
            |||:|.::| ..|...:..|.:|.|.::|    |||..:.|.||.:||.|.:.:.||:...|:.:
  Fly    40 SSNATTASAIAINPAQSLANTSTHSASST----GSSTPDLSTNNTSSSSNATTSPQNSAKMPSSM 100

  Fly    71 LNEAYTKMTSDILAERTLGDFLTEHPGELIRTSSPLFVCTVLPPHWRSNKTLPVAFKVVSLGDIM 135
                     :|:.|  :|.:.|.|:.|||.:|.||..:|:.||.||||||:||.||||::|.|:.
  Fly   101 ---------TDMFA--SLHEMLQEYHGELAQTGSPSILCSALPNHWRSNKSLPGAFKVIALDDVP 154

  Fly   136 DGTMVTVRAGNDENYCAELRNCTAVMKNQVAKFNDLRFVGRSGRGKSFTLTITVSTNPPHIATYN 200
            |||:|:::.|||||||.||||||..||||||||||||||||||||||||||||::|.|..||:|:
  Fly   155 DGTLVSIKCGNDENYCGELRNCTTTMKNQVAKFNDLRFVGRSGRGKSFTLTITIATYPVQIASYS 219

  Fly   201 KAIKVTVDGPREPRSKTMLSLLGQQQQFHFAFGQRPFHFSTDPLSGFRMPPIGNCQSASNTHWGY 265
            ||||||||||||||||         |.:.:            |..|...|.:.|.......:..|
  Fly   220 KAIKVTVDGPREPRSK---------QSYGY------------PHPGAFNPFMLNPAWLDAAYMTY 263

  Fly   266 GSAASAYSPYLASSGLSSCTTPTSAQFNNPALGFTCSSNDQSNNQDFGGATNRDCVPMLPDSTAS 330
            |     |:.|......:.     :||.::|||..:.:|:...|                |:.:.:
  Fly   264 G-----YADYFRHQAAAQ-----AAQVHHPALAKSSASSVSPN----------------PNPSVA 302

  Fly   331 DLDQHLSSLVGSTSGQMTHHSLLGAGGQTSISSTVNGAS--GGGSAGAGTAGGGAGSGGGAGGGA 393
                                        ||.||.|..:.  ...:|.|..||..|.......|.|
  Fly   303 ----------------------------TSSSSAVQPSEYPHPAAAVAAAAGQPAAMMPSPPGAA 339

  Fly   394 GGNSILVPRYHTN--------------ASNEYNVHSS------------QNGPRSLSDSS---QA 429
            ......:|::..|              |.:.||..::            |:.|..:|.:|   .:
  Fly   340 PATPYAIPQFPFNHVAAAAAAKAATPHAFHPYNFAAAAGLRARNAALHHQSEPVHVSPASSRPSS 404

  Fly   430 ESPVQED-LLTTNT 442
            .||.|:. ||..||
  Fly   405 SSPTQQHVLLKLNT 418

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
RunxA	NP_001259747.1	Runt	95..216	CDD:279225	87/120 (73%)
run	NP_001285501.1	Runt	114..235	CDD:279225	87/120 (73%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	132	1.000	Domainoid score	I3175
eggNOG	1	0.900	-	-		E1_KOG3982
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D109070at6656
OrthoFinder	1	1.000	-	-		FOG0000993
OrthoInspector	1	1.000	-	-		otm14562
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR11950
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X738
	8	7.920