DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment RunxA and runx1

DIOPT Version :9

Sequence 1:	NP_001259747.1	Gene:	RunxA / 4379817	FlyBaseID:	FBgn0083981	Length:	663	Species:	Drosophila melanogaster
Sequence 2:	XP_012813452.1	Gene:	runx1 / 100485449	XenbaseID:	XB-GENE-483164	Length:	500	Species:	Xenopus tropicalis

Alignment Length:	635	Identity:	201/635 - (31%)
Similarity:	277/635 - (43%)	Gaps:	178/635 - (28%)

- Green bases have known domain annotations that are detailed below.

  Fly    55 NNSNTEQNTPP----TPAQLLNEAYTKMTSDILA--------ERTLGDFLTEHPGELIRTSSPLF 107
            :.|.:.:.|||    :|.::.......:|....|        :|.:.:.|::|||||:||.||.|
Frog     6 DTSTSRRFTPPSTTLSPGKMSEPIPLNVTDSSAALVGKLRSTDRNMVEVLSDHPGELVRTDSPNF 70

  Fly   108 VCTVLPPHWRSNKTLPVAFKVVSLGDIMDGTMVTVRAGNDENYCAELRNCTAVMKNQVAKFNDLR 172
            :|:|||.|||.|||||:|||||:|||:.|||:|||.|||||||.|||||.||.||||||:|||||
Frog    71 LCSVLPTHWRCNKTLPIAFKVVALGDVPDGTLVTVMAGNDENYSAELRNATAAMKNQVARFNDLR 135

  Fly   173 FVGRSGRGKSFTLTITVSTNPPHIATYNKAIKVTVDGPREPRSKTMLSLLGQQQQFHFAFGQRPF 237
            |||||||||||||||||.||||.:|||::|||:|||||||||                    ||.
Frog   136 FVGRSGRGKSFTLTITVFTNPPQVATYHRAIKITVDGPREPR--------------------RPK 180

  Fly   238 HFSTDPLSGFRMPPI--GNCQSASNTHWGYGSAASAYSPY-LASSGLSSCTTPTSAQFNNPALGF 299
            :   ||:.|   |.:  |..|            |..||.| |..|..|||            :|.
Frog   181 Y---DPIIG---PGLVGGQIQ------------AEIYSIYSLGKSADSSC------------VGS 215

  Fly   300 TCSSNDQSNNQDFGGATNRDCVPMLPDSTASDLDQHLSSLVGSTSGQMTHHSLLGAGGQTSISST 364
            ......:.:.|...|..:.       ....|:| :||.......|   .||.          :.|
Frog   216 FTGHRQKLDEQTKSGTLSF-------SERLSEL-EHLRRTAMRVS---PHHP----------TPT 259

  Fly   365 VNGASGGGSAGAGTAGGGAGSGGGAGGGAGGNSILVPRYHTNASNEYNVHSSQNGPRS-LSDSS- 427
            .|                                  ||...|.|..:|..     |:| :.|:.
Frog   260 PN----------------------------------PRATLNHSTAFNPQ-----PQSQIQDTRQ 285

  Fly   428 -QAESPVQED-------LLTTNTPNLGSTAGGGAANGGAGSNAGSGAAGSGAGGAGGASSAVGNP 484
             ||..|...|       .:.|.:.:..:....|.|:.....:|...:..|||...    :|..:|
Frog   286 VQASPPWSYDQSYQYLGSIATQSVHPATPISPGRASSMTSLSAELSSRLSGASDL----TAFSDP 346

  Fly   485 AMLGANQNF---PGIVNQAQHSAASAYGGGTGVVGG-GHG-SAAAAAAGCNGSLYPVLPASLLYS 544
             .:|.::.|   |.|.:...|...:.....|.|..| |.| ||..:|...:..|.|..|.|   |
Frog   347 -RVGIDRQFSTLPSISDPRMHYPGAFTYTPTPVTSGIGIGMSAMTSATRYHTYLPPPYPGS---S 407

  Fly   545 QLYTAANQSAHGFHSHTLPAHASPNSSVHGELQSVMDHISNVGVRQQHNIMAGGGVTHPGDLTLI 609
            |..::..|:            :||:..::        :.::.|...|.::|:||..:.|..|...
Frog   408 QAQSSPFQT------------SSPSYHLY--------YGTSAGSYHQFSMMSGGDRSPPRILPPC 452

  Fly   610 GNC--GASVRNIEDGNSNRQVAALAAHRGHHNPTDNG------GSVWRPY 651
            .|.  |:::.|....|.|..|.|..:|  .::||:.|      .:|||||
Frog   453 TNASTGSTLLNPNLPNQNDVVEAEGSH--SNSPTNMGTTPRLEEAVWRPY 500

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
RunxA	NP_001259747.1	Runt	95..216	CDD:279225	97/120 (81%)
runx1	XP_012813452.1	Runt	58..178	CDD:279225	97/139 (70%)
runx1	XP_012813452.1	RunxI	407..500	CDD:285676	26/114 (23%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	213	1.000	Domainoid score	I2697
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000993
OrthoInspector	1	1.000	-	-		mtm9362
Panther	1	1.100	-	-	O	PTHR11950
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X738
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	7	7.010