DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment ND-49 and nduf-2.2

DIOPT Version :9

Sequence 1:	NP_001259064.1	Gene:	ND-49 / 43798	FlyBaseID:	FBgn0039909	Length:	468	Species:	Drosophila melanogaster
Sequence 2:	NP_498423.1	Gene:	nduf-2.2 / 188912	WormBaseID:	WBGene00006463	Length:	474	Species:	Caenorhabditis elegans

Alignment Length:	477	Identity:	305/477 - (63%)
Similarity:	375/477 - (78%)	Gaps:	34/477 - (7%)

- Green bases have known domain annotations that are detailed below.

  Fly    18 LRP-QLVAAGSAALTSQETRRGAAKWYPDPEFMKQF-SGPVMYPDEVTSLW---TVPPWNSKV-- 75
            |.| :.||....|::::::.   ..||||.:|.:|| :|..:     ..||   .|..::.::
Worm     6 LHPLRAVACARPAISNRDSH---TIWYPDAKFERQFKTGGTL-----GKLWMSERVSDFDDQIGL 62

  Fly    76 ---------TPV----------EKSVRNLTLNFGPQHPAAHGVLRLVLELDGETVMRADPHIGLL 121
                     .||          ||::.|:.||||||||||||||||||:|:||.:::|.||||||
Worm    63 DKLEKLAYSDPVLSDNYEGKKREKNLENMILNFGPQHPAAHGVLRLVLKLEGEVIIKAIPHIGLL 127

  Fly   122 HRGTEKLIEYKTYTQALPYFDRLDYVSMMCNEQCYSLAVEKLLNIDVPLRAKYIRTLFAEITRIL 186
            ||.||||||:|||||||||||||||||||||||.:|||:||||.||||.||||||.||.|:|||.
Worm   128 HRATEKLIEHKTYTQALPYFDRLDYVSMMCNEQAFSLAIEKLLGIDVPPRAKYIRILFGELTRIQ 192

  Fly   187 NHIMAVGTHALDVGALTPFFWLFEEREKMMEFYERVSGARMHAAYIRPGGVSLDMPLGLMDDIYE 251
            ||||.:.||||||||:|||||:||||||:.||.||||||||||.|:|||||:.|:|:|||||||:
Worm   193 NHIMGITTHALDVGAMTPFFWMFEEREKLFEFSERVSGARMHANYVRPGGVAWDLPVGLMDDIYD 257

  Fly   252 FASKFAERLDEVEDVLTTNRIWVQRTEDIGIVTAEEALNYGFSGVMLRGSGIKWDLRKQQPYDAY 316
            :|.||..|:||:||:||.||||..||.|||:|:|.:|||:||||||:||||||.|:||.:|||||
Worm   258 WAVKFPARIDELEDMLTENRIWKARTVDIGLVSASDALNWGFSGVMVRGSGIKQDVRKTEPYDAY 322

  Fly   317 NLVNFDVPIGTKGDCYDRYLCRVEEMRQSLRIIDQCLNQMPAGEIKTDDAKVAPPSRSEMKTSME 381
            ..:.||||||||||||||||||||||||||.|:.||||:||.||||:||.||.||.|:|||.:||
Worm   323 ADMEFDVPIGTKGDCYDRYLCRVEEMRQSLNIVHQCLNKMPTGEIKSDDHKVVPPKRAEMKENME 387

  Fly   382 ALIHHFKLFTQGYQVPPGATYTAIEAPKGEFGVYLISDGSSRPYRCKIKAPGFAHLAALEKIGKQ 446
            :||||||.||:|:||||||||..||||||||||||::||:.:||||.|:|||||||||:..:...
Worm   388 SLIHHFKFFTEGFQVPPGATYVPIEAPKGEFGVYLVADGTGKPYRCFIRAPGFAHLAAIHDVCYM 452

  Fly   447 HMLADVVAIIGTLDVVFGEIDR 468
            .::||:||:|||:|:||||:||
Worm   453 SLIADIVAVIGTMDIVFGEVDR 474

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
ND-49	NP_001259064.1	PRK06075	79..468	CDD:180385	285/388 (73%)
ND-49	NP_001259064.1	NuoD	79..468	CDD:223722	285/388 (73%)
nduf-2.2	NP_498423.1	PRK06075	85..474	CDD:180385	285/388 (73%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C160159970
Domainoid	1	1.000	428	1.000	Domainoid score	I304
eggNOG	1	0.900	-	-		E1_COG0649
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H56659
Inparanoid	1	1.050	629	1.000	Inparanoid score	I465
Isobase	1	0.950	-	0	Normalized mean entropy	S1889
OMA	1	1.010	-	-		QHG60638
OrthoDB	1	1.010	-	-		D212488at33208
OrthoFinder	1	1.000	-	-		FOG0003234
OrthoInspector	1	1.000	-	-		otm14271
orthoMCL	1	0.900	-	-		OOG6_101051
Panther	1	1.100	-	-	O	PTHR11993
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R3933
SonicParanoid	1	1.000	-	-		X2189
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
	17	16.750