DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment ND-49 and gas-1

DIOPT Version :9

Sequence 1:	NP_001259064.1	Gene:	ND-49 / 43798	FlyBaseID:	FBgn0039909	Length:	468	Species:	Drosophila melanogaster
Sequence 2:	NP_510569.1	Gene:	gas-1 / 181646	WormBaseID:	WBGene00001520	Length:	482	Species:	Caenorhabditis elegans

Alignment Length:	478	Identity:	311/478 - (65%)
Similarity:	375/478 - (78%)	Gaps:	31/478 - (6%)

- Green bases have known domain annotations that are detailed below.

  Fly    16 LRLRPQLVAAGSAALTSQETRRGAAKWYPDPEFMKQF-SGPVMYPDEVTSLW---TVPPWNSKV- 75
            ||.....|||.|:...:| ||.....||||.:|.:|| :|..:     ..||   .|..::.|:
Worm    11 LRANVPSVAATSSTPATQ-TRNSHTIWYPDAKFERQFKTGGTL-----GKLWMSERVSDFDEKIG 69

  Fly    76 ----------TPV----------EKSVRNLTLNFGPQHPAAHGVLRLVLELDGETVMRADPHIGL 120
                      .||          ||::.|:.||||||||||||||||||:|:||.:::|.|||||
Worm    70 LDKLEKLAYSDPVMSDNYSGKQREKNLENMILNFGPQHPAAHGVLRLVLKLEGEVIIKAIPHIGL 134

  Fly   121 LHRGTEKLIEYKTYTQALPYFDRLDYVSMMCNEQCYSLAVEKLLNIDVPLRAKYIRTLFAEITRI 185
            |||.||||||:|||||||||||||||||||||||.:||||||||.||:|.||||||||..|:|||
Worm   135 LHRATEKLIEHKTYTQALPYFDRLDYVSMMCNEQAWSLAVEKLLGIDIPTRAKYIRTLMGELTRI 199

  Fly   186 LNHIMAVGTHALDVGALTPFFWLFEEREKMMEFYERVSGARMHAAYIRPGGVSLDMPLGLMDDIY 250
            .||||.:.||||||||:|||||:||||||:.||.||||||||||.|:|||||:.|:|:|||||||
Worm   200 QNHIMGITTHALDVGAMTPFFWMFEEREKLFEFSERVSGARMHANYVRPGGVAWDLPIGLMDDIY 264

  Fly   251 EFASKFAERLDEVEDVLTTNRIWVQRTEDIGIVTAEEALNYGFSGVMLRGSGIKWDLRKQQPYDA 315
            ::|.||.||:||:||:||.||||..||.|||:|:|.:|||:||||||:||||||.|:||.:||||
Worm   265 DWAIKFPERIDELEDMLTENRIWKARTIDIGLVSAADALNWGFSGVMVRGSGIKQDVRKTEPYDA 329

  Fly   316 YNLVNFDVPIGTKGDCYDRYLCRVEEMRQSLRIIDQCLNQMPAGEIKTDDAKVAPPSRSEMKTSM 380
            |..:.||||||||||||||||||:|||||||.|:.||||:|||||||.||.||.||.|:|||.:|
Worm   330 YADMEFDVPIGTKGDCYDRYLCRIEEMRQSLNIVHQCLNKMPAGEIKVDDHKVVPPKRAEMKENM 394

  Fly   381 EALIHHFKLFTQGYQVPPGATYTAIEAPKGEFGVYLISDGSSRPYRCKIKAPGFAHLAALEKIGK 445
            |:||||||.||:|:||||||||..||||||||||||::||:.:||||.|:|||||||||:..:..
Worm   395 ESLIHHFKFFTEGFQVPPGATYVPIEAPKGEFGVYLVADGTGKPYRCFIRAPGFAHLAAIHDVCY 459

  Fly   446 QHMLADVVAIIGTLDVVFGEIDR 468
            ..::||:||:|||:|:||||:||
Worm   460 MSLIADIVAVIGTMDIVFGEVDR 482

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
ND-49	NP_001259064.1	PRK06075	79..468	CDD:180385	286/388 (74%)
ND-49	NP_001259064.1	NuoD	79..468	CDD:223722	286/388 (74%)
gas-1	NP_510569.1	NuoD	90..482	CDD:223722	286/391 (73%)
gas-1	NP_510569.1	PRK06075	93..482	CDD:180385	286/388 (74%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C160159969
Domainoid	1	1.000	428	1.000	Domainoid score	I304
eggNOG	1	0.900	-	-		E1_COG0649
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H56659
Inparanoid	1	1.050	629	1.000	Inparanoid score	I465
Isobase	1	0.950	-	0	Normalized mean entropy	S1889
OMA	1	1.010	-	-		QHG60638
OrthoDB	1	1.010	-	-		D212488at33208
OrthoFinder	1	1.000	-	-		FOG0003234
OrthoInspector	1	1.000	-	-		otm14271
orthoMCL	1	0.900	-	-		OOG6_101051
Panther	1	1.100	-	-	LDO	PTHR11993
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X2189
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
	17	16.720