Protein Alignment Pur-alpha and PURB

DIOPT Version :10

• Sequence 1: NP_524624.1
• Gene: Pur-alpha / 43797
• FlyBaseID: FBgn0022361
• Length: 275
• Species: Drosophila melanogaster
• Sequence 2: NP_150093.1
• Gene: PURB / 5814
• HGNCID: 9702
• Length: 312
• Species: Homo sapiens
• Alignment Length: 284
• Identity: 128/284 - (45%)
• Similarity: 177/284 - (62%)
• Gaps: 41/284 - (14%)

  Fly     9 DGISGSKYNVANMEGSSSRNDFDSSAKGGSGVE-QELATKMLQIQSKRFYLDVKQNRRGRFIKVA 72
            ||.|||:..     |......|..:::||...| ||||:|.|.||:||||||||||.:|||:|:|
Human     3 DGDSGSERG-----GGGGPCGFQPASRGGGEQETQELASKRLDIQNKRFYLDVKQNAKGRFLKIA 62

  Fly    73 EIGADGRRSQIYLALSTAAEFRDHLSSFSDYYASLGPPNTDNL---PEDG-----KLKSEMMIKD 129
            |:||.|.:|::.|:::.||||||.|..|.::||.|||.:.:.|   .|:|     .||||.::::
Human    63 EVGAGGSKSRLTLSMAVAAEFRDSLGDFIEHYAQLGPSSPEQLAAGAEEGGGPRRALKSEFLVRE 127

  Fly   130 YRRYYLDLKENARGRFLRVSQTITRGG-------------PRSQIALPAQGMIEFRDALTDLLEE 181
            .|:||||||||.||||||:.||:.|||             ....|||||||:|||||||..|:::
Human   128 NRKYYLDLKENQRGRFLRIRQTVNRGGGGFGAGPGPGGLQSGQTIALPAQGLIEFRDALAKLIDD 192

  Fly   182 FGAND--------------GGRFKGDLPEERHMKVDNKNFYFDIGQNNRGVYMRISEVKNNFRTS 232
            :|..|              ||...|:|||...:.||:|.|:||:|.|..||::|:||||.::|.:
Human   193 YGGEDDELAGGPGGGAGGPGGGLYGELPEGTSITVDSKRFFFDVGCNKYGVFLRVSEVKPSYRNA 257

  Fly   233 ITIPEKCWIRFRDIFNDYCEKMKK 256
            ||:|.|.|.:|...|..|.::||:
Human   258 ITVPFKAWGKFGGAFCRYADEMKE 281

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Pur-alpha	NP_524624.1	PurA	41..254	CDD:282672	117/248 (47%)
PURB	NP_150093.1	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1..32		10/33 (30%)
		DNA-binding. /evidence=ECO:0000250|UniProtKB:O35295	28..254		108/225 (48%)
		PurA	31..279	CDD:282672	116/247 (47%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	284..312