Protein Alignment Pur-alpha and PURA

DIOPT Version :10

• Sequence 1: NP_524624.1
• Gene: Pur-alpha / 43797
• FlyBaseID: FBgn0022361
• Length: 275
• Species: Drosophila melanogaster
• Sequence 2: NP_005850.1
• Gene: PURA / 5813
• HGNCID: 9701
• Length: 322
• Species: Homo sapiens
• Alignment Length: 266
• Identity: 126/266 - (47%)
• Similarity: 168/266 - (63%)
• Gaps: 22/266 - (8%)

  Fly     2 SDLGSGDDGISGSKYNVANMEGSSSRNDFDSSAKGGSGVE-QELATKMLQIQSKRFYLDVKQNRR 65
            |..|||..|..|.        |..........|.||...| ||||:|.:.||:||||||||||.:
Human    26 SGSGSGGGGGGGG--------GGGGSGGGGGGAPGGLQHETQELASKRVDIQNKRFYLDVKQNAK 82

  Fly    66 GRFIKVAEIGADGRRSQIYLALSTAAEFRDHLSSFSDYYASLGPPNTDNLPE-----DGKLKSEM 125
            |||:|:||:||.|.:|::.|::|.|.||||:|..|.::||.|||....:|.:     ...||||.
Human    83 GRFLKIAEVGAGGNKSRLTLSMSVAVEFRDYLGDFIEHYAQLGPSQPPDLAQAQDEPRRALKSEF 147

  Fly   126 MIKDYRRYYLDLKENARGRFLRVSQTITR----GGPRSQ-IALPAQGMIEFRDALTDLLEEFGAN 185
            ::::.|:||:|||||.||||||:.||:.|    |..:.| |||||||:|||||||..|::::|..
Human   148 LVRENRKYYMDLKENQRGRFLRIRQTVNRGPGLGSTQGQTIALPAQGLIEFRDALAKLIDDYGVE 212

  Fly   186 DGGRFKGDLPEERHMKVDNKNFYFDIGQNNRGVYMRISEVKNNFRTSITIPEKCWIRFRDIFNDY 250
            :.   ..:|||...:.||||.|:||:|.|..||:||:||||..:|.|||:|.|.|.:|...|..|
Human   213 EE---PAELPEGTSLTVDNKRFFFDVGSNKYGVFMRVSEVKPTYRNSITVPYKVWAKFGHTFCKY 274

  Fly   251 CEKMKK 256
            .|:|||
Human   275 SEEMKK 280

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Pur-alpha	NP_524624.1	PurA	41..254	CDD:282672	113/223 (51%)
PURA	NP_005850.1	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1..55		10/36 (28%)
		PurA	58..278	CDD:282672	112/222 (50%)
		PUR repeat I. /evidence=ECO:0000305|PubMed:20976240	60..125		37/64 (58%)
		PUR repeat II. /evidence=ECO:0000305|PubMed:20976240	142..213		39/70 (56%)
		PUR repeat III. /evidence=ECO:0000305|PubMed:20976240	215..281		34/66 (52%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	295..322