DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Pur-alpha and Purb

DIOPT Version :9

Sequence 1:	NP_001259062.1	Gene:	Pur-alpha / 43797	FlyBaseID:	FBgn0022361	Length:	275	Species:	Drosophila melanogaster
Sequence 2:	NP_001017503.2	Gene:	Purb / 498407	RGDID:	1559465	Length:	317	Species:	Rattus norvegicus

Alignment Length:	288	Identity:	128/288 - (44%)
Similarity:	176/288 - (61%)	Gaps:	44/288 - (15%)

- Green bases have known domain annotations that are detailed below.

  Fly     9 DGISGSKYNVANMEGSSSRNDFDSSAKGGSG-----VEQELATKMLQIQSKRFYLDVKQNRRGRF 68
            ||.|||:..    .|......|..:.:||.|     ..||||:|.|.||:||||||||||.:|||
  Rat     3 DGDSGSERG----GGGGGPGSFQPAPRGGGGPGGEQETQELASKRLDIQNKRFYLDVKQNAKGRF 63

  Fly    69 IKVAEIGADGRRSQIYLALSTAAEFRDHLSSFSDYYASLGPPNTDNL---PEDG-----KLKSEM 125
            :|:||:||.|.:|::.|:::.||||||.|..|.::||.|||.:.:.|   .|:|     .||||.
  Rat    64 LKIAEVGAGGSKSRLTLSMAVAAEFRDSLGDFIEHYAQLGPSSPEQLAAGAEEGGGPRRALKSEF 128

  Fly   126 MIKDYRRYYLDLKENARGRFLRVSQTITRGG-------------PRSQIALPAQGMIEFRDALTD 177
            ::::.|:||||||||.||||||:.||:.|||             ....|||||||:|||||||..
  Rat   129 LVRENRKYYLDLKENQRGRFLRIRQTVNRGGGGFGGGPGPGGLQSGQTIALPAQGLIEFRDALAK 193

  Fly   178 LLEEFGAND--------------GGRFKGDLPEERHMKVDNKNFYFDIGQNNRGVYMRISEVKNN 228
            |::::|..|              ||...|:|||...:.||:|.|:||:|.|..||::|:||||.:
  Rat   194 LIDDYGGEDDELAGGPGGGAGGPGGGLYGELPEGTSITVDSKRFFFDVGCNKYGVFLRVSEVKPS 258

  Fly   229 FRTSITIPEKCWIRFRDIFNDYCEKMKK 256
            :|.:||:|.|.|.:|...|..|.::||:
  Rat   259 YRNAITVPFKAWGKFGGAFCRYADEMKE 286

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Pur-alpha	NP_001259062.1	PurA	41..254	CDD:282672	116/247 (47%)
Purb	NP_001017503.2	PurA	36..284	CDD:282672	116/247 (47%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	202..222		3/19 (16%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	290..317
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166341841
Domainoid	1	1.000	222	1.000	Domainoid score	I2502
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	231	1.000	Inparanoid score	I3358
OMA	1	1.010	-	-		QHG59777
OrthoDB	1	1.010	-	-		D1248813at2759
OrthoFinder	1	1.000	-	-		FOG0001061
OrthoInspector	1	1.000	-	-		otm45056
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	LDO	PTHR12611
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X718
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	12	12.010