DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Pur-alpha and purbb

DIOPT Version :9

Sequence 1:	NP_001259062.1	Gene:	Pur-alpha / 43797	FlyBaseID:	FBgn0022361	Length:	275	Species:	Drosophila melanogaster
Sequence 2:	NP_956841.1	Gene:	purbb / 393519	ZFINID:	ZDB-GENE-040426-1478	Length:	297	Species:	Danio rerio

Alignment Length:	273	Identity:	131/273 - (47%)
Similarity:	177/273 - (64%)	Gaps:	47/273 - (17%)

- Green bases have known domain annotations that are detailed below.

  Fly    29 DFDS-SAKGGS--GVE--------QELATKMLQIQSKRFYLDVKQNRRGRFIKVAEIGADGRRSQ 82
            |.|| |.:|||  |::        ||||:|.|.||:||||||||||.:|||||:||:||.|.:|:
Zfish     3 DGDSGSERGGSSGGLQHFQREQETQELASKRLDIQNKRFYLDVKQNAKGRFIKIAEVGAGGSKSR 67

  Fly    83 IYLALSTAAEFRDHLSSFSDYYASLGPPNTDNLP-----EDG----KLKSEMMIKDYRRYYLDLK 138
            :.|::|.||||||:|..|.::||.|||.:.:.:.     :||    .||||.::::.|:||||||
Zfish    68 LTLSMSVAAEFRDYLGDFIEHYAQLGPSSPEQIAQSSGGDDGGPRRALKSEFLVRENRKYYLDLK 132

  Fly   139 ENARGRFLRVSQTITR---------GGP------RSQIALPAQGMIEFRDALTDLLEEFGAND-- 186
            ||.||||||:.||:.|         |||      ...|||||||:|||||||..|::::|..|
Zfish   133 ENQRGRFLRIRQTVNRGPGFGVGGGGGPGGGVQAGQTIALPAQGLIEFRDALAKLIDDYGGEDEE 197

  Fly   187 --------GGRFKGDLPEERHMKVDNKNFYFDIGQNNRGVYMRISEVKNNFRTSITIPEKCWIRF 243
                    ||  .|:|||...:.||:|.|:||:|.|..||::|:||||.::|.|||||.|.|.:|
Zfish   198 LSGGPGAAGG--YGELPEGTSIMVDSKRFFFDVGSNKYGVFLRVSEVKPSYRNSITIPFKAWGKF 260

  Fly   244 RDIFNDYCEKMKK 256
            ...|:.|.|:||:
Zfish   261 GGAFSRYAEEMKE 273

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Pur-alpha	NP_001259062.1	PurA	41..254	CDD:282672	121/254 (48%)
purbb	NP_956841.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..26		8/22 (36%)
		PurA	26..271	CDD:282672	121/246 (49%)
		PUR	28..90	CDD:197840	38/61 (62%)
		PUR	115..192	CDD:197840	40/76 (53%)
		PUR	211..272	CDD:197840	30/60 (50%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	275..297
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170581870
Domainoid	1	1.000	231	1.000	Domainoid score	I2363
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	238	1.000	Inparanoid score	I3330
OMA	1	1.010	-	-		QHG59777
OrthoDB	1	1.010	-	-		D1248813at2759
OrthoFinder	1	1.000	-	-		FOG0001061
OrthoInspector	1	1.000	-	-		otm25439
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	LDO	PTHR12611
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R4144
SonicParanoid	1	1.000	-	-		X718
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	12	12.040