DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Pur-alpha and Pura

DIOPT Version :9

Sequence 1:	NP_001259062.1	Gene:	Pur-alpha / 43797	FlyBaseID:	FBgn0022361	Length:	275	Species:	Drosophila melanogaster
Sequence 2:	NP_033015.1	Gene:	Pura / 19290	MGIID:	103079	Length:	321	Species:	Mus musculus

Alignment Length:	283	Identity:	128/283 - (45%)
Similarity:	174/283 - (61%)	Gaps:	31/283 - (10%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MSDLGSGDD------GISGSKYNVANMEGSSSRNDFDSSAKGGSG-----------VEQELATKM 48
            |:|..||.:      |..||..:..:..||..... .....||||           ..||||:|.
Mouse     1 MADRDSGSEQGGAALGSGGSLGHPGSGSGSGGGGG-GGGGGGGSGGGGGAPGGLQHETQELASKR 64

  Fly    49 LQIQSKRFYLDVKQNRRGRFIKVAEIGADGRRSQIYLALSTAAEFRDHLSSFSDYYASLGPPNTD 113
            :.||:||||||||||.:|||:|:||:||.|.:|::.|::|.|.||||:|..|.::||.|||....
Mouse    65 VDIQNKRFYLDVKQNAKGRFLKIAEVGAGGNKSRLTLSMSVAVEFRDYLGDFIEHYAQLGPSQPP 129

  Fly   114 NLPE-----DGKLKSEMMIKDYRRYYLDLKENARGRFLRVSQTITR----GGPRSQ-IALPAQGM 168
            :|.:     ...||||.::::.|:||:|||||.||||||:.||:.|    |..:.| |||||||:
Mouse   130 DLAQAQDEPRRALKSEFLVRENRKYYMDLKENQRGRFLRIRQTVNRGPGLGSTQGQTIALPAQGL 194

  Fly   169 IEFRDALTDLLEEFGANDGGRFKGDLPEERHMKVDNKNFYFDIGQNNRGVYMRISEVKNNFRTSI 233
            |||||||..|::::|..:.   ..:|||...:.||||.|:||:|.|..||:||:||||..:|.||
Mouse   195 IEFRDALAKLIDDYGVEEE---PAELPEGTSLTVDNKRFFFDVGSNKYGVFMRVSEVKPTYRNSI 256

  Fly   234 TIPEKCWIRFRDIFNDYCEKMKK 256
            |:|.|.|.:|...|..|.|:|||
Mouse   257 TVPYKVWAKFGHTFCKYSEEMKK 279

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Pur-alpha	NP_001259062.1	PurA	41..254	CDD:282672	112/222 (50%)
Pura	NP_033015.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..54		13/53 (25%)
		PurA	57..277	CDD:282672	112/222 (50%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	294..321
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167838064
Domainoid	1	1.000	224	1.000	Domainoid score	I2542
eggNOG	1	0.900	-	-		E1_KOG3074
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	229	1.000	Inparanoid score	I3444
Isobase	1	0.950	-	0	Normalized mean entropy	S3963
OMA	1	1.010	-	-		QHG59777
OrthoDB	1	1.010	-	-		D1248813at2759
OrthoFinder	1	1.000	-	-		FOG0001061
OrthoInspector	1	1.000	-	-		otm42992
orthoMCL	1	0.900	-	-		OOG6_106010
Panther	1	1.100	-	-	O	PTHR12611
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X718
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
	16	15.720