DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Thd1 and tdg.1

DIOPT Version :9

Sequence 1:	NP_001259060.1	Gene:	Thd1 / 43796	FlyBaseID:	FBgn0026869	Length:	1738	Species:	Drosophila melanogaster
Sequence 2:	NP_001018587.1	Gene:	tdg.1 / 553789	ZFINID:	ZDB-GENE-050522-44	Length:	441	Species:	Danio rerio

Alignment Length:	462	Identity:	165/462 - (35%)
Similarity:	226/462 - (48%)	Gaps:	105/462 - (22%)

- Green bases have known domain annotations that are detailed below.

  Fly   644 MGEELH---MHSPS----------HRHLDAVTT-----GPGRYGILVSNDTPECLSREMYRHSQQ 690
            |.|.|:   .|:||          .:||..:..     ..|..|.::.....:...::|..|.:.
Zfish     1 MDERLYGSLPHAPSEYLQQWVQSAQQHLQTLQAQYPHMANGSAGFMMEGQREDAGMQQMPVHPED 65

  Fly   691 STTV--------------LEQTDSSSCGINFKPMPK-------KRGRKKKLVAVNADTSQMTTPV 734
            :..:              ..||       |.:|.||       |.|.|.|    .|...:...|.
Zfish    66 AAQLQPAAAQTAPAKGKRARQT-------NKEPKPKGEPKPRAKPGPKPK----KAKEDKEAPPA 119

  Fly   735 D-QQKVSAGRADCEDGGGDQAAKPKERKKHDRFNGMSEEEVIKRTIPDHLCDNLDIVIVGINPGL 798
            : |:|:            |:..| |.::|.|||.|||||||:|||:||.|..|||.||:||||||
Zfish   120 EGQEKI------------DETFK-KVKRKVDRFKGMSEEEVMKRTLPDILIPNLDYVIIGINPGL 171

  Fly   799 FAAYKGHHYAGPGNHFWKCLYLAGLTQEQMSADEDHKL-IKQGIGFTNMVARATKGSADLTRKEI 862
            .|||.|..:.||||||||||:|:|.|::.::..:|..| .|.||||||||||||.||.||:.||:
Zfish   172 MAAYIGRWFPGPGNHFWKCLFLSGFTEKLLNHMDDQSLPEKYGIGFTNMVARATPGSKDLSSKEL 236

  Fly   863 KEGSRILLEKLQRFRPKVAVFNGKLIFEVFS----GK--KEFHFGRQPDRVDGTDTFIWVMPSSS 921
            :||.:||:||:::|:|.:||||||.|:|:|.    ||  |...||.||.::..:||.:::|||||
Zfish   237 REGGKILVEKIKQFKPLIAVFNGKCIYEMFCRELFGKKPKTLEFGLQPHKIPDSDTALYLMPSSS 301

  Fly   922 ARCAQLPRAADKVPFYAALKKFRDFLNGQIPHIDESECVFT-------DQRIRLCSAQQQVDIVG 979
            |||||.|||.|||.||..|::.||.|.|.|...:..|..:|       :...|:...::|.|
Zfish   302 ARCAQFPRAQDKVHFYIKLRELRDQLKGVIKQKEVEEVNYTFDLGLAKEDAKRIAVKEEQYD--- 363

  Fly   980 KINKTHQPPLGDHPSSLTVVSNCSG---PIAGDAE--CGIVAEESDQVQSEKMIPQMDPTVPSS- 1038
                         |..........|   |..|.:.  |...|.|.:...:||.     ||.||.
Zfish   364 -------------PGYEAAFGGAYGEAAPEGGQSNGICNFSASEENANTAEKA-----PTKPSDV 410

  Fly  1039 SNATDGK 1045
            ....||:
Zfish   411 GQVQDGQ 417

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Thd1	NP_001259060.1	UDG_like	714..962	CDD:294330	127/255 (50%)
tdg.1	NP_001018587.1	UDG_like	<114..357	CDD:294330	125/255 (49%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170594883
Domainoid	1	1.000	173	1.000	Domainoid score	I3647
eggNOG	1	0.900	-	-		E1_COG3663
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0006159
OrthoInspector	1	1.000	-	-		otm24883
orthoMCL	1	0.900	-	-		OOG6_104831
Panther	1	1.100	-	-	O	PTHR12159
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R1493
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
ZFIN	0	0.000	Not matched by this tool.
	11	10.730