Protein Alignment Tdg and tdg.1

DIOPT Version :10

• Sequence 1: NP_651925.1
• Gene: Tdg / 43796
• FlyBaseID: FBgn0026869
• Length: 1738
• Species: Drosophila melanogaster
• Sequence 2: NP_001018587.1
• Gene: tdg.1 / 553789
• ZFINID: ZDB-GENE-050522-44
• Length: 441
• Species: Danio rerio
• Alignment Length: 462
• Identity: 165/462 - (35%)
• Similarity: 226/462 - (48%)
• Gaps: 105/462 - (22%)

  Fly   644 MGEELH---MHSPS----------HRHLDAVTT-----GPGRYGILVSNDTPECLSREMYRHSQQ 690
            |.|.|:   .|:||          .:||..:..     ..|..|.::.....:...::|..|.:.
Zfish     1 MDERLYGSLPHAPSEYLQQWVQSAQQHLQTLQAQYPHMANGSAGFMMEGQREDAGMQQMPVHPED 65

  Fly   691 STTV--------------LEQTDSSSCGINFKPMPK-------KRGRKKKLVAVNADTSQMTTPV 734
            :..:              ..||       |.:|.||       |.|.|.|    .|...:...|.
Zfish    66 AAQLQPAAAQTAPAKGKRARQT-------NKEPKPKGEPKPRAKPGPKPK----KAKEDKEAPPA 119

  Fly   735 D-QQKVSAGRADCEDGGGDQAAKPKERKKHDRFNGMSEEEVIKRTIPDHLCDNLDIVIVGINPGL 798
            : |:|:            |:..| |.::|.|||.|||||||:|||:||.|..|||.||:||||||
Zfish   120 EGQEKI------------DETFK-KVKRKVDRFKGMSEEEVMKRTLPDILIPNLDYVIIGINPGL 171

  Fly   799 FAAYKGHHYAGPGNHFWKCLYLAGLTQEQMSADEDHKL-IKQGIGFTNMVARATKGSADLTRKEI 862
            .|||.|..:.||||||||||:|:|.|::.::..:|..| .|.||||||||||||.||.||:.||:
Zfish   172 MAAYIGRWFPGPGNHFWKCLFLSGFTEKLLNHMDDQSLPEKYGIGFTNMVARATPGSKDLSSKEL 236

  Fly   863 KEGSRILLEKLQRFRPKVAVFNGKLIFEVFS----GK--KEFHFGRQPDRVDGTDTFIWVMPSSS 921
            :||.:||:||:::|:|.:||||||.|:|:|.    ||  |...||.||.::..:||.:::|||||
Zfish   237 REGGKILVEKIKQFKPLIAVFNGKCIYEMFCRELFGKKPKTLEFGLQPHKIPDSDTALYLMPSSS 301

  Fly   922 ARCAQLPRAADKVPFYAALKKFRDFLNGQIPHIDESECVFT-------DQRIRLCSAQQQVDIVG 979
            |||||.|||.|||.||..|::.||.|.|.|...:..|..:|       :...|:...::|.|
Zfish   302 ARCAQFPRAQDKVHFYIKLRELRDQLKGVIKQKEVEEVNYTFDLGLAKEDAKRIAVKEEQYD--- 363

  Fly   980 KINKTHQPPLGDHPSSLTVVSNCSG---PIAGDAE--CGIVAEESDQVQSEKMIPQMDPTVPSS- 1038
                         |..........|   |..|.:.  |...|.|.:...:||.     ||.||.
Zfish   364 -------------PGYEAAFGGAYGEAAPEGGQSNGICNFSASEENANTAEKA-----PTKPSDV 410

  Fly  1039 SNATDGK 1045
            ....||:
Zfish   411 GQVQDGQ 417

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Tdg	NP_651925.1	UDG-like	714..962	CDD:444933	127/255 (50%)
		motif A	793..797	CDD:381679	3/3 (100%)
tdg.1	NP_001018587.1	UDG-like	<114..357	CDD:444933	125/255 (49%)
		motif A	166..170	CDD:381679	3/3 (100%)