Protein Alignment zfh2 and zfhx2

DIOPT Version :10

• Sequence 1: NP_524623.2
• Gene: zfh2 / 43795
• FlyBaseID: FBgn0004607
• Length: 3005
• Species: Drosophila melanogaster
• Sequence 2: XP_001335082.5
• Gene: zfhx2 / 795005
• ZFINID: ZDB-GENE-030131-6699
• Length: 1529
• Species: Danio rerio
• Alignment Length: 1850
• Identity: 351/1850 - (18%)
• Similarity: 600/1850 - (32%)
• Gaps: 616/1850 - (33%)

  Fly  1330 ESPKVAETEVGVQ-------CPLCLENHFREKQYLEDHLTSVHSVTRDGLSRLLLLV-------- 1379
            |.|:  ||.||..       ||||.|:| .:::.|..||:..|||....|.:||.:.
Zfish     3 EEPE--ETLVGASNKGSMWLCPLCQESH-ADRENLSHHLSDKHSVLPACLDKLLTIAAPKHPSIA 64

  Fly  1380 -DQKALKKESTDIACPTDKAPYANTNALERAPTPIENTCNVSLIKSTSANPSQSVSLQGLSCQQC 1443
             |:::..:...|   .|.:....|.|    :||......|.|.........|:...|.    ::.
Zfish    65 EDEESKSQNHAD---DTSQLNSENRN----SPTLAFQNENESTDAVDKCGSSEEKELD----EEI 118

  Fly  1444 EASFKHEEQLLKHAQQNQHFSLQNGEYLCLAASHISRPCFMTFRTIPTMISHFQDLHMSLIISER 1508
            |.. ::||..:...:.||    .|||              .|.:|....:|:.:.:..:.:..|.
Zfish   119 EGG-RNEEIDMGDLESNQ----DNGE--------------QTIKTSDASVSNGRSVCKNSVAYEF 164

  Fly  1509 HVYKYRCKQCSLAFKTQEKLTTHMLYHS------MRDAT--------------------KCSFCQ 1547
            ...:::|..|..:|..:..|:.|  |:|      ||..|                    :|:.|:
Zfish   165 DNSRFKCNACLESFPNRTALSVH--YNSTTHIQRMRTGTVKDSDSIPFLSRPYVSTKPYQCAICR 227

  Fly  1548 RNFRSTQALQKHMEQA-------HAEDGTPSTRTNS---------------PQTPMLSTEE---- 1586
            .::.....|:.|::..       .|.:.|||:..|:               ..|.:::|..
Zfish   228 VSYNHAITLESHLKSVLHQSRSRSAGNATPSSTANTGTGTMGTRLAPTTIGSNTQLVNTSTSNCV 292

  Fly  1587 THKHLLAESHAVEREVSGSDVSPIELETHLNKETRHLSPTPMSLDSQSHQKHLATFAALLKQQQ- 1650
            |..:|.|.:...:   .|..|.|            .|:|:.:|....|.|...|....|.....
Zfish   293 TQANLTATAVTTK---DGEQVQP------------QLAPSLLSSPVASAQAMSAILTLLTSSPNS 342

  Fly  1651 -------------CNSDAGGLHPEALSMSTGEMPPQLQGLQNLQHIQQHFGAVAAAAGLPINPVD 1702
                         .::..|...|:.:......||..|.|||:...:|..            |...
Zfish   343 LPHSILPPLFTTGTSATPGAATPQLIPQPQMLMPLVLNGLQSQTQVQGQ------------NQDS 395

  Fly  1703 MLNIMQFHHLMSLNFMNLAPPLVFGANAAGNAVSGPSALNNSITTSTATSASGLGDTHLTSGVSS 1767
            ...::|           .|.| |.|.:||..|:             .|...|||.......|:.:
Zfish   396 PKQLLQ-----------QAVP-VLGLSAAQQAL-------------LAQRLSGLQSQWAAFGLPA 435

  Fly  1768 IPVDSGKATAVPPQTQLNANANSQQLASNQKRARTRITD----DQLKILRAHFDINNSPSEESIM 1828
            ..:...:||               :||...|....:...    ||...||:..|.|....::.:.
Zfish   436 TKMSLEEAT---------------KLAERSKDMAVQCIKVEPCDQQMSLRSEEDWNIDGVKKDLC 485

  Fly  1829 EMSQKANLPMKVVKHWFRNTLFKERQRNKDSPYNFNNPPSTTLNLEEYERTGQAKVTPLNDTCSV 1893
            ..::...|..   ::...:....|::..::......|..|.....:...:..::.|||
Zfish   486 FKNENTQLQS---ENMMGDGTADEKEHEENEMDVEGNDESLCEGEDANSKVTKSSVTP------- 540

  Fly  1894 AVTGPMTSSTIS--LPP------SGNINLSSKENATSK-----VLAAGKANASGPVTFSATVPVS 1945
               |....|.:|  |.|      |.|||.|...|.|.:     :..||..:|...:..|:..||.
Zfish   541 ---GFQHESPLSCVLDPNQGLRHSHNINSSGTANYTFRNTNFALQFAGHRSAKDHLLLSSGRPVL 602

  Fly  1946 TPL----------SRPESTNSSGNISD--YIGNNIFFGQLGSKEQILPYSLDGQIKSEPQDDMIG 1998
            |..          ||.::..||....|  .:|..:..    |.|::..:.||
Zfish   603 TEFQSQVLWAFLESRDDAETSSPQREDCEALGREVGL----SGEEVRKWFLD------------- 650

  Fly  1999 ATDFAYQTKQHSSFSFLKQQQDLVDPPEQCLTNQNADTAQDQSLLAGSSLASNCQSQQQINIFET 2063
                |:|:|.                      ....|...|:|:           .:::.|:...
Zfish   651 ----AWQSKD----------------------KDRLDRFHDESM-----------EEEEGNLMID 678

  Fly  2064 KSESGSSDVLSRPPSPNSGAAGNVYGSMNDLLNQQLENMGSNMGPPKKMQIVGKTFEKNVAPMVT 2128
            :||.|.|     |.:..|.|..         |:...|......|.|:::             ::|
Zfish   679 ESEDGHS-----PSATGSHAID---------LSSSGERHRIGKGSPREL-------------LLT 716

  Fly  2129 SGSVSTQF-------ESNSSNSSSSSSSTSGGKRANRTRFTDYQI----KVLQEFFENNSYPKDS 2182
            |.|.:.:|       :..|.:||....|.|..|::::...|..:.    |||:   ....:..|:
Zfish   717 SDSENEEFYTSVIVTDEESQSSSMREESGSPIKQSSQVEPTPEKSSGGGKVLR---STTVFLSDA 778

  Fly  2183 DLEYLSKLLLLSPRVIVVWFQNARQKQRKIYENQPNNTLFENEETKKQNINYACKKCNLVFQRYY 2247
            :.||..:             |:.::|:||             .|..|:::.
Zfish   779 EDEYDDE-------------QSMKKKRRK-------------SEIAKEDVE-------------- 803

  Fly  2248 ELIRHQKNHCFKEENNKKSAKAQIAAAQIAQNLSSEDSNSSMDIHHVGICPPGSAVASHTLSTPG 2312
                      .|:|........|:.|.      :...:..|:.:...|:  |.:.:.|..:|.
Zfish   804 ----------IKQEKQDLDLDLQLEAQ------ADPPTPLSITVDQQGV--PANILQSLPISL-- 848

  Fly  2313 SAAPLPGQYTQHSFGALPS------------PQHLFAKS---SSLTDFSPSTTPTPPQRERSNSL 2362
            |.|||..|.......:|||            .:..|:.:   |:|:|  |...|:......||..
Zfish   849 SLAPLSTQLYSPYVLSLPSSVIGVGVSEGDRAKIAFSNTQPVSALSD--PLNAPSTTHSFLSNGN 911

  Fly  2363 DQIQRPPKFDCDKCELNFNQLEKLREH--------------QLLHLMNPGNICSDVGQNSNPEAN 2413
            |            ||...: |...:.|              |..||::        |....|...
Zfish   912 D------------CESALD-LSMGKNHSSTISVSTANRPSIQKSHLLD--------GLGLRPTTV 955

  Fly  2414 FGPF--GSILQSLQQAAAQQQQQHHQQPPTKKRKYSDCSS---NADEMQSLSELEASQKKHEYLY 2473
            ..|.  |.|:..::..:|.............:...:..|:   .|.|..:.|.:|..::|
Zfish   956 GVPTDGGLIVVQVKPDSAIAIPSSTNSTLINRNNLAKTSTVYMRAAEKVTTSLIEREKEK----- 1015

  Fly  2474 KYFMQNETSQEVK----QQFLMQQQQKKLEQGNECDFELDFLTNFY------QQNELKKVSNY-- 2526
                :.|..|:.|    ::|...::.:.:...:    :||.|...|      .::|.:::|.:
Zfish  1016 ----EREKEQDQKRPKVRRFRDMRRSRTIIHAD----QLDILYGCYFKDPNPGKHEFEQISEWVN 1072

  Fly  2527 ------DFLLQYYRTHE---EAKSSQQHTFSSSKKPTIEFLLQYYQLNESKKFFQLVASPQIIPD 2582
                  ....|..|..|   |.:.....|.::..||.|:|....     ||..|   ::|
Zfish  1073 LPKKVVQIWFQNMRARERKGEVRFISDGTLAAVGKPLIKFTWPL-----SKPIF---SNP----- 1124

  Fly  2583 VPGYKPSLRIPKSTSDEAPYIGETSLEQAT--------ELQREKQDEQLRIDRPSEENDLS---- 2635
                      |||.:  :|..|.||.:..|        :|:..|:..:.....||..|..:
Zfish  1125 ----------PKSNT--SPSTGWTSAKPQTGNILPKIEKLKEVKEPLKAPHQGPSRPNQTTSFTV 1177

  Fly  2636 ------MNKNKVENINNNNINVDQSNLTE------TNGGVPSVETK-----EECTQESSLIAMDD 2683
                  :.|.|.|......:.:....:|.      ...|:|:..:.     ||...||
Zfish  1178 VSTSPLIQKIKTEVAPITMVKIAPKTVTTPVAVPLLVSGIPTSRSAPKRKVEEVQAES------- 1235

  Fly  2684 ENKYLCTRSKQKDDKEKSHYLHNLEDFLDATMIENNSQTLTFNDDEKACQK-------------- 2734
                      :..|:|..|....||......|:...:.|........|.||
Zfish  1236 ----------EHTDEEDDHCQGGLESGTTNLMVPKLTTTPINKPAALASQKQNGLKYWPQKGPFK 1290

  Fly  2735 ------DEL---TQNSNAIEKRSSVSPVNVSS------------KQN---KRLRTTILPEQLNFL 2775
                  ::|   :|...|....::.||:.|::            :||   :|.||.:...||:.|
Zfish  1291 INTLSREQLGLSSQRPTATTTPTTPSPLTVTASPSQSQKEISYMQQNSTPRRPRTHLTSLQLSIL 1355

  Fly  2776 YECYQSESNPSRKMLEEISKKVNLKKRVVQVWFQNSRAKDKKSRNQRH--YAHISD-DNSYDGSS 2837
            ..||::.::|:....|.:..::.|..:|||:||||:|||:|:.|.|:.  ..:.|| ....|.||
Zfish  1356 QSCYETCAHPNALECEAVGTELGLPLKVVQIWFQNTRAKEKRWRLQQEKMSPNPSDPSKKIDVSS 1420

  Fly  2838 GKEV-YSDLRSN-------------------GITVDTDLETNLQDCQLCQV---TQVNIRKHAFS 2879
            |..: |:.||:|                   .|...|..||.:..|..|..   ::...|.|.||
Zfish  1421 GSYLQYNALRANRPILPKPVQLTVVDPAPSYNIGQTTVRETLIGKCDACGAEFESRAAARDHVFS 1485

  Fly  2880 VEHISKMKKLLEQTTELYAQ----SNGSGS 2905
            ..|::.::     ||....|    |||||:
Zfish  1486 ARHLATLR-----TTNFGLQASMVSNGSGT 1510

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
zfh2	NP_524623.2	C2H2 Zn finger	561..581	CDD:275368
		C2H2 Zn finger	616..633	CDD:275368
		C2H2 Zn finger	1515..1542	CDD:275371	10/52 (19%)
		C2H2 Zn finger	1543..1564	CDD:275371	4/27 (15%)
		Homeodomain	1798..1857	CDD:459649	9/62 (15%)
		Homeodomain	2155..2211	CDD:459649	9/59 (15%)
		Homeodomain	2761..2817	CDD:459649	21/55 (38%)
zfhx2	XP_001335082.5	C2H2 Zn finger	171..193	CDD:275368	7/23 (30%)
		zf-met	221..245	CDD:463736	4/23 (17%)
		C2H2 Zn finger	223..241	CDD:275368	4/17 (24%)
		Homeodomain	1039..1091	CDD:459649	9/55 (16%)
		Homeodomain	1341..1397	CDD:459649	21/55 (38%)