Protein Alignment zfh2 and Zfhx2

DIOPT Version :10

• Sequence 1: NP_524623.2
• Gene: zfh2 / 43795
• FlyBaseID: FBgn0004607
• Length: 3005
• Species: Drosophila melanogaster
• Sequence 2: NP_001092273.1
• Gene: Zfhx2 / 305888
• RGDID: 735143
• Length: 2558
• Species: Rattus norvegicus
• Alignment Length: 3048
• Identity: 653/3048 - (21%)
• Similarity: 959/3048 - (31%)
• Gaps: 1212/3048 - (39%)

  Fly   215 SDATLPS------SPQPVFRNVSELEPENKQETEQNRLLNQDREQEPESDQHTSSSKMAAPSAYI 273
            |..|:||      ||.|...:.|..:|..|...:........|..|| ..:|..|.:..||...|
  Rat     9 SSGTIPSPGHHVPSPSPETSSSSTSDPVTKDPPDAPSTAESIRSSEP-GGEHLESGRDLAPPKEI 72

  Fly   274 ----------PLSSPKVAG---------KLTVKFGSLNSATAKTNNLSKVSSTSSP----PSTYA 315
                      |: .||..|         .|.:....|.||..:...|:.:|.:...    |..:.
  Rat    73 GEPRHEPGCGPI-PPKDLGVSKEEKGILPLDLSNHLLFSAGGQAYLLANLSLSGGSELLLPKGFP 136

  Fly   316 SGEVL---SPSTDNISNHKSTH----------------------CNQETEPPSSSSSEVEMKIGS 355
            ..|..   .||...:::..|:|                      .:.:|..||.::  .|.:.||
  Rat   137 WDEASVKEEPSLPLLAHFPSSHLTTLHIQHGFDPVQGFSSSDQILSHDTSAPSLAA--CEGRDGS 199

  Fly   356 -----MSTSPQTNDSDVPCS------------------GFLQMQ----H-MTTGGAYTPQVSSFH 392
                 :..:|..:..|.|..                  ||.::|    | ::.|...||   :.|
  Rat   200 FWSYQLVPNPTEDPKDGPMGSRRGDHRAMFWICLLCRLGFGRLQAFIGHTLSHGVKLTP---AHH 261

  Fly   393 ASLAALAA--NESNDNRVKLITEFLQQQLQQHQSSLFPSPCPDHPDLNGVDCKTCEL-------- 447
            ..|....|  .|.:|..:..:: ||:.:|..|       |.|:.||.:.|..||...
  Rat   262 QGLLGSPAVLQEGHDGGMAFLS-FLEPKLLTH-------PSPEVPDTSTVTVKTNGAQAEDGPPE 318

  Fly   448 LDIQ-----------------------------QRSKSPSSSHHQFSQSLPQLQIQSQPQQTP-- 481
            .|:|                             |..:||.|.........|:.|.:......|
  Rat   319 ADVQALVLPGEEVMALSPPSPPTALATWDPSPTQAKESPVSRGEAGPDWFPEGQEEDGGLCLPLN 383

  Fly   482 HRSPCSNSVALPVSPSAS--SVASVGNASTATSSFTIGACSEHINGRPQGVDCARCEMLLNSARL 544
            ..||.|..||:..:|:.|  ..:....:...|..:|....:.      ||:..:....||:|
  Rat   384 QSSPTSKEVAVLPAPAGSPEDTSDPPQSCRLTDDYTPAPAAF------QGLSLSSHMSLLHS--- 439

  Fly   545 NSGVQMSTRNSCKTLKCPQCNWHYKYQETLEIHMREKHPDGESACGYCLAGQQHPRLARGESYSC 609
                    ||||||||||:||||||||:||::|||||||:..|.|.||.||..||||||||||:|
  Rat   440 --------RNSCKTLKCPKCNWHYKYQQTLDVHMREKHPESNSHCSYCSAGGAHPRLARGESYNC 496

  Fly   610 GYKPYRCEICNYSTTTKGNLSIHMQSDKHLNNMQELNSSQNMVAAAAAAAVTGKLLLSSSSPQVT 674
            |||||||::|||||||||||||||||||||.|:|
  Rat   497 GYKPYRCDVCNYSTTTKGNLSIHMQSDKHLANLQ------------------------------- 530

  Fly   675 AACPSNSGSGAGSGSSNIVGGTASLSGNATPSVTGANSSNANAGSNTNNAGTKPKPSFRCDICSY 739
                   |..||.|            |.|:|  ..|:....:.|...    .|.|.|::|.:|||
  Rat   531 -------GFQAGPG------------GQASP--PEASLPPPSIGEKE----PKTKSSWQCKVCSY 570

  Fly   740 DTSVARNLRIHMTSEKHTHNMAVLQNNI-------------------------KHIQAF--NFLQ 777
            :|:::||||||||||||..|:.:|...:                         :..|.|  ..|.
  Rat   571 ETNISRNLRIHMTSEKHMQNVLMLHQGLPLGLPPGLVGPGPPPPPGAAPTNPPELFQYFGPQALG 635

  Fly   778 QQQQSGTGNIASHSSGSFMPEVALADLAYNQALMIQLLHQQQQHQQSANTKLSPSSSPVSTPDQF 842
            |.|.|             ||...|..   ::.|..||| ....|...|..:..|:::|.|...:.
  Rat   636 QPQTS-------------MPGPGLRP---DKPLEAQLL-LNGFHHLGAPARKFPTAAPGSLSPET 683

  Fly   843 SFSPKPIKLNHGTGAAMGIGMAMGMGMSHSNEVSCELSGDPHPLTKTDKWPMAFYSCLVCDCYST 907
            ...|..:                 :|.|     |..||..|.|   .|..|:..:.||||..:||
  Rat   684 HLPPSQL-----------------LGSS-----SDGLSTSPSP---DDSPPLKVFRCLVCQAFST 723

  Fly   908 NNLDDLNQHLLLDRSRQSSSASSEIMVIHNNNYICRLCNYKTNLKANFQLHSKTDKHLQKLNFIN 972
            ::|:.|..|..:.|    :...:|...:..:.:.|:||.|.|.||||||||.|||||.||.....
  Rat   724 DSLELLLYHCSIGR----TLPEAEWKEVAGDTHRCKLCCYGTQLKANFQLHLKTDKHTQKYQLAA 784

  Fly   973 HIREGG-----PQNEYKMQYQQQQLAANVVQLKCNCCDFHTNSIQKLSLHTQQMRHDTMRMIFQH 1032
            |:||||     |.............:.:.:.|:||.|||.:||.:|:.||.:...|:....|::.
  Rat   785 HLREGGGAMGSPSPLSLGDGTSYGGSVSPLHLRCNICDFESNSKEKMQLHARGSAHEENSQIYKF 849

  Fly  1033 LLYIVQQSEMHNKSSGSAEDDPQCACPDEDQQLQLQSSKKLLLCQLCNFTAQNIHEMVQHVKGIR 1097
            ||      ||....:|          |:..          |..|.||.:...:...::||::...
  Rat   850 LL------EMEGAEAG----------PEPG----------LYHCLLCAWDTPSRLAVLQHLRMPA 888

  Fly  1098 HLQVEQFICLQRRSE-NQEIPALNEVFKVTEWVMENEDVSLAPGLNLARTTTNDATTDASYAAAS 1161
            |...:    .|||.: .|..||..|.....:.::     |.:.|    |..|.....|...|.
  Rat   889 HRDAQ----AQRRLQLLQSGPAAEEGLSALQSIL-----SFSRG----RLQTPGKAPDTPLAQ-- 938

  Fly  1162 SAAVPAIPDVSMFSPTSPSSCATSCDKNLSQIVLPNVNNLGSGVP------TTVFKCNLCEYFVQ 1220
                         .|||........::..|::....     :|.|      .|||.|..|.:...
  Rat   939 -------------PPTSEKDAQNRTEQRASEVTEDR-----TGPPRDSANQITVFCCPYCSFLSP 985

  Fly  1221 SKSEIAAHIETEHSCAESDEFITIPTNTAALQAFQTAVAAAALAAVHQRCAVINPPTQDTVDEDK 1285
            ...::..|..::|                |:|
  Rat   986 ECDQVRVHTLSQH----------------AVQ--------------------------------- 1001

  Fly  1286 DLDTNVSDGPVGIKQERLEQEVDRTTSMDVTKDLASQATDFGAPESPKVAETEVGVQCPLCLEN- 1349
                                                          ||       .:||||.|.
  Rat  1002 ----------------------------------------------PK-------YRCPLCQEQL 1013

  Fly  1350 ------HFREKQYLEDHLTSVHSVTRDGLSRLLLLVDQKALKKESTDIACPTDKAPYANTN---- 1404
                  ||        ||:.:|:|..:.:.:|||:.       .:.::...|...|....|
  Rat  1014 VGRPALHF--------HLSHLHNVVPECVEKLLLVA-------TTVEMTFATKMLPGPTLNPVED 1063

  Fly  1405 ALER-----APTP----IENTCNVSLIKSTSANPSQSVSLQGLSCQQCEASFKHEEQLLKHAQQN 1460
            .|||     .|||    :.::.|::...|....|.....|..:     |...:..|.    .||.
  Rat  1064 GLERPAPGPEPTPNRDQVADSSNLAPEASPDPPPPPEPPLAPV-----EGPMEPSES----PQQP 1119

  Fly  1461 QHFSLQNGEYLCLAASHISRPCFMT--FRTIPTMISHFQDLHMSLIISE-----------RHV-Y 1511
            .          ..|:|.:.||....  ...:|||....:.     ::.|           ||: |
  Rat  1120 P----------SPASSPVPRPDAQVEELTPLPTMSEEEEG-----VMGEPRSAEPSPADSRHLTY 1169

  Fly  1512 K----------------YRCKQCSLAFKTQEKLTTHMLY------HSMRDAT------------- 1541
            :                |:|..|..:|..:..|..|  |      |.|:.|.
  Rat  1170 RKTTNFALDKFLDPARPYKCTVCKESFTQKNILLVH--YNSVSHLHKMKKAAIDPSCPARGEAGI 1232

  Fly  1542 ------------KCSFCQRNFRSTQALQKHM----EQAHAEDGTPSTRTNSPQTPMLSTEETHKH 1590
                        ||:.|:.::..:..|:.||    .|..:.......||..|:.   |.||
  Rat  1233 PPPTTTASDKPFKCTVCRVSYNQSSTLEIHMRSVLHQTRSRGAKTDARTEGPER---SQEE---- 1290

  Fly  1591 LLAESHA---VEREVSGSDVS------PIELETHLNKETRHLSPTPMSLDSQSHQKHLATFAALL 1646
             |.|...   |..|..|.|.|      |.            |||.|..||       |..|.|.|
  Rat  1291 -LKEGETEGEVGTEKKGPDPSGFMSGLPF------------LSPPPPPLD-------LHRFPAPL 1335

  Fly  1647 KQQQCNSDAGGLHPEALSMSTGEMPPQLQGLQNLQHIQQHFGAVAAAAGLPINPVDMLNIMQFHH 1711
                       ..|..|       ||                       .|:.|..:|.:.|...
  Rat  1336 -----------FTPPVL-------PP-----------------------FPLVPESLLKLQQQQL 1359

  Fly  1712 LMS--LNFMNLAPPLVFGANAAGNAVSGPSALNNSITTSTATSASGLGDTHLTSGVSSIPVDSGK 1774
            |:.  |:.:.:.|.|         |::.|:                             |:.|..
  Rat  1360 LLPFYLHDLKVGPKL---------ALASPT-----------------------------PMLSLP 1386

  Fly  1775 ATAVPPQTQLNANANSQQLASNQKRARTRITDDQLKILRAHFDINNSPSEESIMEMSQKANLPMK 1839
            |...||                                                       ||.
  Rat  1387 AANPPP-------------------------------------------------------LPA- 1395

  Fly  1840 VVKHWFRNTLFKERQRNKDSPYNFNNPPSTTLNLEEYERTGQAKVTPLNDTCSVAVTGPMTSSTI 1904
                                      ||...|..:|:||       ||     :|..|  |.:..
  Rat  1396 --------------------------PPKAELAEQEWER-------PL-----IAEEG--TEAGP 1420

  Fly  1905 SLPPSGNINLSSK-------ENATSKVLA---AGKANASGPVTFSATVPVSTPLSRPESTNSSGN 1959
            |.||..:.|.:::       ||...:::.   .||         .|..|..|| ..|||...
  Rat  1421 SSPPHSSPNEAARTAAKALLENFGFELVIQYNEGK---------QAVPPPPTP-PPPESLGG--- 1472

  Fly  1960 ISDYIGNNIFFGQLG---SKEQILPYSLDGQIKSEPQDDMIGATDFAYQTKQHSSFSFLKQQQDL 2021
                 |:.:..|..|   |...||          :..::.:......::.....:..|.|....|
  Rat  1473 -----GDKLACGACGKLFSNMLIL----------KTHEEHVHRRFLPFEALSRYAAQFRKSYDSL 1522

  Fly  2022 VDPPEQCLTNQNADTAQDQSLLAGSSLASNCQSQQQINIFETKSESGSSDVLSRPPSPNSGAAGN 2086
            ..||.:                                                ||.|..|:
  Rat  1523 YPPPVE------------------------------------------------PPKPPDGS--- 1536

  Fly  2087 VYGSMNDLLNQQLENMGSNMGPPKKMQIVGKTFEKNVAPMVTSGSVSTQFESNSSNSSSSSSSTS 2151
                        ||:      ||:    :|..|   |.|....|.:.|..|...:.....|....
  Rat  1537 ------------LES------PPQ----LGPPF---VVPEPEVGGIHTSEERGLAGGPWPSEEEE 1576

  Fly  2152 G--------GKRANRTRFTDYQIKVLQEFFENNSYPKDSDLEYLSKLLLLSPRVIVVWFQNARQK 2208
            |        |:|.:||:||::|.:.||.|||.::||||.::|.|:.||.|:.||:||||||||||
  Rat  1577 GSRGSVVPVGRRFSRTKFTEFQTQALQSFFETSAYPKDGEVERLASLLGLASRVVVVWFQNARQK 1641

  Fly  2209 QRK-IYENQPNNTLFENEETKKQNINYACKKCNLVFQRYYELIRHQKNHCF-------KEENNKK 2265
            .|| ..|..|   :.....|...:   .|::|:..|...:||:||.|. ||       :||..:.
  Rat  1642 ARKNACEGGP---MTAGGATGGAS---GCRRCHATFACVFELVRHLKK-CFDDQPPAEEEEAERG 1699

  Fly  2266 SAKAQIAAAQIAQNLSSEDSNSSMDIHHVGICPPGSAVASHTLSTPGSAAPLPGQYTQHSFGALP 2330
            ..:.::...::      |:.|......| |...|..|.|...    |.|.|           ..|
  Rat  1700 EEEEEVEEEEV------EERNPEPAGRH-GDRSPERANAEDV----GQAEP-----------TRP 1742

  Fly  2331 SPQHLFAKSSSLTDFSPSTTPTPPQRERSNSLDQIQRPPKFDCDKCELNFNQLEKLREHQLLHLM 2395
            ..:....|:             ||.            ||...||:|.::|...:.|..|..||
  Rat  1743 ESKETEGKA-------------PPS------------PPAHTCDQCSISFPSQDLLTTHHRLH-- 1780

  Fly  2396 NPGNICSDVGQNSNPEANFGPFGSILQSLQQAAAQQ----------QQQHHQQPPTK------KR 2444
                                    .|.|:|.:|..|          ::......|:.      ||
  Rat  1781 ------------------------FLPSVQPSAPSQLLDLPLLVFGERNPVVSGPSSVTGTPLKR 1821

  Fly  2445 KYSD--CSSNADEMQSLSELEASQKKH----------EYLYKYFMQNETSQEVKQQFLMQQQQKK 2497
            |:.|  .|....|.....|.|..:.|.          |.||:::||:            ....:|
  Rat  1822 KHDDGSLSPTGSEAGGGGEGEPPKDKRLRTTILPEQLEILYRWYMQD------------SNPTRK 1874

  Fly  2498 LEQGNECDFELDFLTNFYQQNELKKVSNYDFLLQYYRTHEEAKSSQQHTFSSSKKPTIEFLLQYY 2562
            :         ||.::                        ||.         ..||..::...|..
  Rat  1875 M---------LDCIS------------------------EEV---------GLKKRVVQVWFQNT 1897

  Fly  2563 QLNESKKFFQL----VASPQIIPDV---PGYKPSLRI-------------PKSTSDEAPYIGETS 2607
            :..|.|..|:.    ||.|...|..   |...|...:             ||..:...||...|.
  Rat  1898 RARERKGQFRSTPGGVAGPAAKPTATPSPAPFPKFNLLLSKIEDETGKEAPKREAPAFPYPTVTP 1962

  Fly  2608 LEQATELQREKQDEQLRIDRPSEENDLSMNKNKVENINNNNINVDQSNLTETNGGVPSVETKEEC 2672
            ......|......:::....|.....|.                            ||..:::|.
  Rat  1963 AAAPGPLPFLAPGKEVTAPTPEPPPPLP----------------------------PSALSEDEG 1999

  Fly  2673 TQESSLIAMDDENKYLCTRSKQKDDKEKSHYLHNLEDFLDATMIENNSQTLTFNDDEKACQKDEL 2737
            .:|.|..:.:.|   .|:.|           ..:|.|...:::.|..|.....|......
  Rat  2000 PEEPSKASPESE---ACSPS-----------AGDLSDSSASSLAEPESPGAGGNGGGPGS----- 2045

  Fly  2738 TQNSNAIEKRSSVSPVNVSSKQNKRLRTTILPEQLNFLYECYQSESNPSRKMLEEISKKVNLKKR 2802
                         .|........:|.||.:...||..:..||::...|:.:..|.:.:::.|.||
  Rat  2046 -------------GPGVPDGMGQRRYRTQMSSLQLKIMKACYEAYRTPTMQECEVLGEEIGLPKR 2097

  Fly  2803 VVQVWFQNSRAKDKKSRNQRHYAHISDDNSYDGSSGKEVYSDLRSNGITVDTDLETNLQDCQLCQ 2867
            |:||||||:|||:||::.|    ..:...|..||.|...                ....||..|.
  Rat  2098 VIQVWFQNARAKEKKAKLQ----GTAPAGSGGGSEGPSA----------------AQRTDCPYCD 2142

  Fly  2868 VT---QVNIRKHAFSVEHISKMKKLLEQTTELYAQSNGSGSEDNDSDREKRFYNLSKA 2922
            |.   .|:.|.|.||.:|::|:|:.:.      ||...          |.:.|:|:.|
  Rat  2143 VKYDFYVSCRGHLFSRQHLAKLKEAVR------AQLKS----------ESKCYDLAPA 2184

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
zfh2	NP_524623.2	C2H2 Zn finger	561..581	CDD:275368	15/19 (79%)
		C2H2 Zn finger	616..633	CDD:275368	14/16 (88%)
		C2H2 Zn finger	1515..1542	CDD:275371	9/57 (16%)
		C2H2 Zn finger	1543..1564	CDD:275371	6/24 (25%)
		Homeodomain	1798..1857	CDD:459649	2/58 (3%)
		Homeodomain	2155..2211	CDD:459649	32/55 (58%)
		Homeodomain	2761..2817	CDD:459649	22/55 (40%)
Zfhx2	NP_001092273.1	C2H2 Zn finger	448..468	CDD:275368	15/19 (79%)
		zf-H2C2_5	501..525	CDD:404746	21/23 (91%)
		C2H2 Zn finger	503..520	CDD:275368	14/16 (88%)
		C2H2 Zn finger	1189..1211	CDD:275368	6/23 (26%)
		C2H2 Zn finger	1246..1264	CDD:275368	4/17 (24%)
		Homeodomain	1587..1644	CDD:459649	32/56 (57%)
		Homeodomain	1847..1903	CDD:459649	15/109 (14%)
		Homeodomain	2056..2112	CDD:459649	22/55 (40%)
		PHA03247	<2183..2296	CDD:223021	1/2 (50%)
		C2H2 Zn finger	2439..2482	CDD:275371
		C2H2 Zn finger	2483..2505	CDD:275371