DRSC/TRiP Functional Genomics Resources

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Protein Alignment zfh2 and zfh-2

DIOPT Version :9

Sequence 1:NP_524623.2 Gene:zfh2 / 43795 FlyBaseID:FBgn0004607 Length:3005 Species:Drosophila melanogaster
Sequence 2:NP_001370923.1 Gene:zfh-2 / 171670 WormBaseID:WBGene00022518 Length:1615 Species:Caenorhabditis elegans


Alignment Length:2545 Identity:563/2545 - (22%)
Similarity:814/2545 - (31%) Gaps:1187/2545 - (46%)


- Green bases have known domain annotations that are detailed below.


  Fly   447 LLDIQQRSKSPSSSHHQFSQSLPQLQIQSQPQQTPHRSPCSNSVALPVSPSASSV---------- 501
            ||.:...:|.|:||.          ..:|:....|.....:..:.|...||.:.:          
 Worm     5 LLTMDDNNKPPTSSE----------STESRETSPPMMPDSAEIMRLLTDPSTAQMFANENTKCQL 59

  Fly   502 -----ASVGNASTATSSF----TIGACSEHINGRPQGVDCARCEMLLNSARLNSGVQMSTRNSCK 557
                 ||..:.::.:|||    |:||.:          |.::..              |.|||.|
 Worm    60 GRILAASGFDEASLSSSFPFDPTLGAFA----------DISQFS--------------SLRNSSK 100

  Fly   558 TLKCPQCNWHYKYQETLEIHMREKHPDGESACGYCLAGQQHPRLARGESYSCGYKPYRCEICNYS 622
            |||||:|||||||||||||||:|||.|.:..|.:|...:.||:|||||:||||||||||::|.||
 Worm   101 TLKCPKCNWHYKYQETLEIHMKEKHNDVDVKCMFCAENRPHPKLARGETYSCGYKPYRCDLCRYS 165

  Fly   623 TTTKGNLSIHMQSDKHLNNMQELNSSQNMVAAAAAAAVTGKLLLSSSSPQVTAACPSNSGSGAGS 687
            |||||||||||||||||:.:|||.:|....|..|..|.     :|.|||                
 Worm   166 TTTKGNLSIHMQSDKHLHAVQELPNSIEFAANFACGAP-----VSRSSP---------------- 209

  Fly   688 GSSNIVGGTASLSGNATPSVTGANSSNANAGSNTNNAGTKPKPSFRCDICSYDTSVARNLRIHMT 752
                                                                             
 Worm   210 ----------------------------------------------------------------- 209

  Fly   753 SEKHTHNMAVLQNNIKHIQAFNFLQQQQQSGTGNIASHSSGSFMPEVALADLAYNQALMIQLLHQ 817
                                               ...|.||.:                     
 Worm   210 -----------------------------------IEESDGSLV--------------------- 218

  Fly   818 QQQHQQSANTKLSPSSSPVSTPDQFSFSPKPIKLNHGTGAAMGIGMAMGMGMSHSNEVSCELSGD 882
                                                                             
 Worm   219 ----------------------------------------------------------------- 218

  Fly   883 PHPLTKTDKWPMAFYSCLVCDCYSTNNLDDLNQHLLLDRSRQSSSASSEIMVIHNNNYICRLCNY 947
                            ||:|..::|.::.::.:|:..||||   :...::.|: |.::.|.||.|
 Worm   219 ----------------CLICGIFATESIAEMMEHVEQDRSR---TFQGDVTVL-NGSFRCHLCPY 263

  Fly   948 KTNLKANFQLHSKTDKHLQKLNFINHIREGGPQNE--YKMQYQQQQLAANVVQLKCNCCDFHTNS 1010
            .|.||||||||::|||||||:...||:|||...:.  |::...:..     ||:.|..|....:|
 Worm   264 NTTLKANFQLHTRTDKHLQKVQIANHLREGTRPHTAIYRLSSTKTS-----VQVLCRQCQEVISS 323

  Fly  1011 IQKLSLH---------TQQM-RHDTMRMIFQHLLYIVQQSEMHNKSSGSAEDDPQCACPDEDQQL 1065
            .:.|..|         .|:: |....|:.|..:|........|..|:          .|:|....
 Worm   324 GESLREHRHFHALLAAKQRLWRCKLCRLEFDSVLLAAGHMTCHEPST----------WPNESLDF 378

  Fly  1066 QLQSSKKLLLCQLCNFTAQNIHEMVQHVKGIRH-----LQVEQFICLQRRSENQEIPALNEVFKV 1125
            :.... ....|..|.||.:::.:..:|.||...     .|....:||:...:.::  .|.|..::
 Worm   379 KTMED-AAYACAGCEFTTKDVSDFEEHAKGHEEEAGASSQKACALCLEPTDDLEK--HLVEQHRI 440

  Fly  1126 TEWVMENEDVSLAPGLNLARTTTNDATTDASYAAASSAAVPAIPDVSMFSPTSPSSCATSCDKNL 1190
            .|..:|.        ..|...|..:|                             ||::|.:   
 Worm   441 AESAIEK--------FLLTERTAKEA-----------------------------SCSSSSE--- 465

  Fly  1191 SQIVLPNVNNLGSGVPTTVF--KCNLCEYFVQSKSEIAAH-----IETEHSCAESDEFITIPTNT 1248
                           |::.|  :|:.|....:|:|::..|     ..|.|.|             
 Worm   466 ---------------PSSEFAHRCSRCSMAFRSESQLQTHSLQHVFNTFHKC------------- 502

  Fly  1249 AALQAFQTAVAAAALAAVHQRCAVINPPTQDTVDEDKDLDTNVSDGPVGIKQERLEQEVDRTTSM 1313
                                      |...|:.||:..:                      |..:
 Worm   503 --------------------------PTCGDSFDENTIV----------------------THML 519

  Fly  1314 DVTKDLASQATDFGAPESPKVAETEVGVQCPLCLENHFREKQYLEDHLTSVHSVTRDGLSRLLLL 1378
            :.||:                       :|.:|.|. |..|:....||.|...            
 Worm   520 EHTKE-----------------------ECEMCSET-FATKEAFLSHLNSARH------------ 548

  Fly  1379 VDQKALKKESTDIACPTDKAPYANTNALERAPTPIENTCNVSLIKSTSANPSQSVSLQGL-SCQQ 1442
                                       |::|...:||    ||:...    ||.|..|.: .|..
 Worm   549 ---------------------------LQQAKKQLEN----SLVDLN----SQDVEKQRIYVCNV 578

  Fly  1443 CEASFKHEEQLLKHAQQNQHFSLQ------------NGEYLCLAASHISRPCFMTFRTIPTMISH 1495
            |:.|:.....|..|.:...|.|..            |||........|..|...:|....|..|.
 Worm   579 CKQSYPQAANLDVHMRSMTHQSRMSRLSELVATGELNGEKAVFEQPGIPAPTINSFIETTTNQSS 643

  Fly  1496 FQDLHMSL-----------------IISERHVYKYRCKQCSLAFKTQEKLTTHMLYHSMRDA--- 1540
            ..|| |||                 ::::..||. ..|..||..:...|:....|:...|.|   
 Worm   644 LNDL-MSLLTRSESDEIREEVNGLQVMTQIKVYG-ESKITSLVPELAGKIDNIALFDDSRAAEVS 706

  Fly  1541 -TKCSFCQRNFRSTQALQKHMEQAHAEDGTPSTRTNSPQTPMLSTEETHKHLLAESHAVEREVSG 1604
             ..||.|.:......||..|.|::|           |.:.|.....:..:.|||           
 Worm   707 KIDCSACGQQISGILALNLHYEESH-----------SSKIPSDVLRKFGERLLA----------- 749

  Fly  1605 SDVSPIELETHLNKE--TRHLSPTPMSLDSQSHQKHLATFAALLKQQQCNSDAGGLHPEALSMST 1667
                  .||..|::|  .::.|.:|:|.|.:..:|                          .|..
 Worm   750 ------ALEDGLSRENSVKNGSQSPLSNDDEPMEK--------------------------KMRL 782

  Fly  1668 GEMPPQLQGLQNLQHIQQHFGAVAAAAGLPINPVDMLNIMQFHHLMSLNFMNLAPPLVFGANAAG 1732
            ..|.|::.  :|           |||:          ....|..:|:. |..:|||    ..::|
 Worm   783 ENMLPEMD--KN-----------AAAS----------QFAMFQQMMNC-FPFMAPP----GTSSG 819

  Fly  1733 NAVSGPSALNNSITTSTATSASGLGDTHLTSGVSSIPVDSGKATAVPPQTQLNANANSQQLASNQ 1797
            |....|..:|..:..:.|.:|                     |||          |.:...|:|.
 Worm   820 NFGFSPEMINQLMNPAAAAAA---------------------ATA----------AAAAHAANNS 853

  Fly  1798 --KRARTRITDDQLKILRAHFDINNSPSEESIMEMSQKANLPMKVVKHWFRNTLFKERQRNKDSP 1860
              |||||||||||||:||.:|:|||||||..|.||||||:||.||:||||||||||||||:||||
 Worm   854 PAKRARTRITDDQLKVLRQYFNINNSPSEAQIKEMSQKASLPEKVIKHWFRNTLFKERQRDKDSP 918

  Fly  1861 YNFNNPPSTTLNLEEYERTGQAKVTPLNDTCSVAVTGPMTSSTISLPPSGNINLSSKENATSKVL 1925
            |||:.||...::|:.||:||:.||                             ||....|....|
 Worm   919 YNFSIPPQMGIDLDIYEKTGETKV-----------------------------LSLSNEAPKSEL 954

  Fly  1926 AAGKANASGPVTFSATVPVSTPLSRPESTNSSGNISDYIGNNIFFGQLGSKEQILPYSLDGQIKS 1990
            ::.:|        :.|:|...||...|.                                   |.
 Worm   955 SSARA--------TPTIPTPIPLIVEEK-----------------------------------KP 976

  Fly  1991 EPQDDMIGATDFAYQTKQHSSFSFLKQQQDLVDPPEQCLTNQNADTAQDQSLLAGSSLASNCQSQ 2055
            ||:.          ||...||     .|.:|                  |::|          ||
 Worm   977 EPKS----------QTPSSSS-----SQLNL------------------QAML----------SQ 998

  Fly  2056 QQINIFETKSESGSSDVLSRPPSPNSGAAGNVYGSMNDLLNQQLENMGSNMGPPKKMQIVGKTFE 2120
            .|.:.|:..:...:|                                                  
 Worm   999 MQGSFFDASNFMSAS-------------------------------------------------- 1013

  Fly  2121 KNVAPMVTSGSVSTQFESNSSNSSSSSSSTSGGKRANRTRFTDYQIKVLQEFFENNSYPKDSDLE 2185
              |.||..|        :.|.|:|||      |:|||||||||:|::.||:||:..:||||.|||
 Worm  1014 --VNPMTPS--------TPSCNTSSS------GRRANRTRFTDFQLRTLQQFFDKQAYPKDDDLE 1062

  Fly  2186 YLSKLLLLSPRVIVVWFQNARQKQRKIYENQPNNTLFENEE--TKKQNINYACKKCNLVFQRYYE 2248
            .|||.|.||||||||||||||||.|||||||||:   |:.:  .:....|:.||:|:.|||||||
 Worm  1063 ALSKKLQLSPRVIVVWFQNARQKARKIYENQPNH---ESSDRFVRTPGSNFQCKRCSQVFQRYYE 1124

  Fly  2249 LIRHQKNHCFKEENNKKSAKAQIAAAQIAQNLSSEDSNSSMDIHHVGICPPGSAVASHTLSTPGS 2313
            ||:||:..|:|::          .||..:.|.|.|:                             
 Worm  1125 LIQHQQKKCYKDD----------VAALASDNKSVEE----------------------------- 1150

  Fly  2314 AAPLPGQYTQHSFGALPSPQHLFAKSSSLTDFSPSTTPTPPQRERSNSLDQIQRPPKFDCDKCEL 2378
                                       |||           :.|:|..|.|              
 Worm  1151 ---------------------------SLT-----------EEEKSQLLAQ-------------- 1163

  Fly  2379 NFNQLEKLREHQLLHLMNPGNICSDVGQNS-NPEANFGPFGSILQSLQQAAAQQQQQHHQQPPTK 2442
              .|:.:|.....|....|..:...:|.|| .|.::             ||:|:           
 Worm  1164 --QQVAQLASTLELPKFQPAELLKMIGANSVTPSSS-------------AASQK----------- 1202

  Fly  2443 KRKYSDCSSNADEMQSLSE--LEASQKKHEYLYKYFMQNETSQEVKQQFLMQQQQKKLEQGNECD 2505
                   ||| |.:..:.|  :..|.......:|..:  ..:|:.|.:..|.:..          
 Worm  1203 -------SSN-DVLLKMCESIVGGSTPSTSSFHKLCI--FCAQDFKDRSAMSEHM---------- 1247

  Fly  2506 FELDFLTNFYQQNELKKVSNYDFLLQYYRTHEEAKSSQQHTFSSSKKPTIEFLLQYYQLNESKKF 2570
                                             |:...||           .||..:.|:     
 Worm  1248 ---------------------------------AQKHPQH-----------MLLPNFDLD----- 1263

  Fly  2571 FQLVASPQIIPDVPGYKPSLRIPKSTSDEAPYIGETSLEQATELQREKQDEQLRIDRPSEENDLS 2635
                    ::||..|                          .||..:.:|..|         |||
 Worm  1264 --------MMPDAGG--------------------------AELLMDLKDSAL---------DLS 1285

  Fly  2636 MNKNKVENINNNNINVDQSNLTETNGGVPSVETKEECTQESSLIAMDDENKYLCTRSKQKDDKEK 2700
                        ..:||..:         |:.|                     :.|:.:||.  
 Worm  1286 ------------GSSVDYRD---------SIST---------------------SPSRSEDDV-- 1306

  Fly  2701 SHYLHNLEDFLDATMIENNSQTLTFNDDEKACQKDELTQNSNAIEKRSSVSPVNVSSKQNKRLRT 2765
                  |.:.||              |...|....:|..:::..|.||..|        |||.||
 Worm  1307 ------LTEALD--------------DSAFAAFGLQLANSTSGSECRSPAS--------NKRFRT 1343

  Fly  2766 TILPEQLNFLYECYQSESNPSRKMLEEISKKVNLKKRVVQVWFQNSRAKDKKSRNQRHYAHISDD 2830
            .:.|.|:..:...:.....||....|.:.|:|.|.||||||||||:|||::|:|.          
 Worm  1344 HLTPMQVQMMKSVFNEYKTPSMAECELLGKEVGLHKRVVQVWFQNARAKERKTRG---------- 1398

  Fly  2831 NSYDGSSGKEVYSDLRSNGITVDTDLETNLQDCQLCQ---VTQVNIRKHAFSVEHISKMKKLL-- 2890
                                .||.|..:....|::|.   .|:::::.|.|:.:||..::..|  
 Worm  1399 --------------------AVDEDSRSGELHCEICDKTFATRLSLQDHLFAEQHIEFLRNNLKR 1443

  Fly  2891 EQTTELYAQS 2900
            |..:||...|
 Worm  1444 EGVSELTTAS 1453

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
zfh2NP_524623.2 C2H2 Zn finger 561..581 CDD:275368 17/19 (89%)
C2H2 Zn finger 616..633 CDD:275368 13/16 (81%)
C2H2 Zn finger 1515..1542 CDD:275371 7/30 (23%)
C2H2 Zn finger 1543..1564 CDD:275371 7/20 (35%)
HOX 1797..1853 CDD:197696 44/57 (77%)
Homeobox 2158..2210 CDD:278475 38/51 (75%)
Homeobox 2764..2816 CDD:278475 23/51 (45%)
zfh-2NP_001370923.1 C2H2 Zn finger 474..494 CDD:275368 5/19 (26%)
C2H2 Zn finger 502..525 CDD:275371 8/106 (8%)
C2H2 Zn finger 526..548 CDD:275371 8/22 (36%)
C2H2 Zn finger 576..598 CDD:275368 5/21 (24%)
HOX 856..915 CDD:197696 48/58 (83%)
COG5576 979..>1091 CDD:227863 67/220 (30%)
Homeobox 1035..1088 CDD:395001 38/52 (73%)
Homeobox 1342..1395 CDD:395001 23/52 (44%)
C2H2 Zn finger 1411..1433 CDD:275371 5/21 (24%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 1 0.930 - - C160165824
Domainoid 1 1.000 100 1.000 Domainoid score I4429
eggNOG 1 0.900 - - E1_KOG1146
Hieranoid 1 1.000 - -
Homologene 00.000 Not matched by this tool.
Inparanoid 1 1.050 456 1.000 Inparanoid score I889
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 1 1.010 - - D11071at33208
OrthoFinder 1 1.000 - - FOG0002899
OrthoInspector 1 1.000 - - oto17237
orthoMCL 1 0.900 - - OOG6_106078
Panther 1 1.100 - - LDO PTHR45891
Phylome 00.000 Not matched by this tool.
RoundUp 00.000 Not matched by this tool.
SonicParanoid 1 1.000 - - X1134
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
1110.890

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