Protein Alignment Asator and TTBK1

DIOPT Version :9

• Sequence 1: NP_651924.2
• Gene: Asator / 43794
• FlyBaseID: FBgn0039908
• Length: 1349
• Species: Drosophila melanogaster
• Sequence 2: XP_016866853.1
• Gene: TTBK1 / 84630
• HGNCID: 19140
• Length: 1409
• Species: Homo sapiens
• Alignment Length: 1472
• Identity: 410/1472 - (27%)
• Similarity: 599/1472 - (40%)
• Gaps: 392/1472 - (26%)

  Fly   152 KESVKMT----SEDLLQPGHVVKERWKVVRKIGGGGFGEIYEGQDLITREQVALKVESARQPKQV 212
            |:...|:    ..|:|...:|||:||||::||||||||||||..||:|||.||||||||:|||||
Human     9 KDETNMSGGGEQADILPANYVVKDRWKVLKKIGGGGFGEIYEAMDLLTRENVALKVESAQQPKQV 73

  Fly   213 LKMEVAVLKKLQGKEHVCRFIGCGRNDRFNYVVMQLQGKNLAELRRAQPRGAFSLSTTLRLGLQI 277
            ||||||||||||||:|||||||||||::||||||||||:|||:|||:||||.|:||||||||.||
Human    74 LKMEVAVLKKLQGKDHVCRFIGCGRNEKFNYVVMQLQGRNLADLRRSQPRGTFTLSTTLRLGKQI 138

  Fly   278 LKAIESIHSVGFLHRDIKPSNFSVGRLPYNCRRVYMLDFGLARQYTTGTGEVRCPRAAAGFRGTV 342
            |::||:||||||||||||||||::||||...|:.||||||||||||..||:||.||..|||||||
Human   139 LESIEAIHSVGFLHRDIKPSNFAMGRLPSTYRKCYMLDFGLARQYTNTTGDVRPPRNVAGFRGTV 203

  Fly   343 RYASINAHRNREMGRHDDLWSLFYMLVEFVNGQLPWRKIKDKEQVGLTKEKYDHRILLKHLPSDL 407
            ||||:|||:||||||||||||||||||||..|||||||||||||||:.||||:||:||||:||:.
Human   204 RYASVNAHKNREMGRHDDLWSLFYMLVEFAVGQLPWRKIKDKEQVGMIKEKYEHRMLLKHMPSEF 268

  Fly   408 KQFLEHIQSLTYGDRPDYAMLIGLFERCMKRRGVKESDPYDWEKVDSTAIGNISATGNPS----- 467
            ..||:||.||.|..:|||.:::.:||..||.||:.|::.:||||..:.|:.:.|.:..|.
Human   269 HLFLDHIASLDYFTKPDYQLIMSVFENSMKERGIAENEAFDWEKAGTDALLSTSTSTPPQQNTRQ 333

  Fly   468 ----------IPIKSDYMHGNITQMTVAASNASG------------------------------- 491
                      .|:..|.:..| |:..:...:.|.
Human   334 TAAMFGVVNVTPVPGDLLREN-TEDVLQGEHLSDQENAPPILPGRPSEGLGPSPHLVPHPGGPEA 397

  Fly   492 -----TEYIRKRAEIETAHITATD-------------------PLNIKEKVDKN---CNAT---- 525
                 |:..|.:..|....:||..                   |:..|..|..:   |.|:
Human   398 EVWEETDVNRNKLRINIGKVTAARAKGVGGLFSHPRFPALCPCPVPPKHPVPGHLPACPASVSRS 462

  Fly   526 -----SLAQPAKGSGEPMVQHGNAANNQNITSKG----LQQQSTLTNSQVAIANIQSAPSMIERE 581
                 ||..|:..|.........:|:::.|:...    |.|...:...|.....:.|:|.....:
Human   463 LPALASLCLPSSSSSVSFTLRRPSAHSRLISPSSWHSPLLQSPCVEEEQSRGMGVPSSPVRAPPD 527

  Fly   582 -------DVQYTKLEE-------------------------GAPTKFITMKPNGECDNVDIAAKC 614
                   .::|.::..                         |:|::........:..:||..
Human   528 SPTTPVRSLRYRRVNSPESERLSTADGRVELPERRSRMDLPGSPSRQACSSQPAQMLSVDTG--- 589

  Fly   615 IFEQKHVEANDDIVGRASLS-GVEQHYKSQIKKHNSPEIANKQIQRTGTVTNDKTSEV------- 671
                   .|:....||..:| .|||...|...: :.|....:.......|..||.:|:
Human   590 -------HADRQASGRMDVSASVEQEALSNAFR-SVPLAEEEDFDSKEWVIIDKETELKDFPPGA 646

  Fly   672 ----NRSTEEQKSTFGRLRVLTAPPMSVHDLPSGGGHSHQVSDLSGKQDPYAATSNAAPIGINSS 732
                :.:|:|:             |..:..||..|....::          .|.....|.|  .|
Human   647 EPSTSGTTDEE-------------PEELRPLPEEGEERRRL----------GAEPTVRPRG--RS 686

  Fly   733 STKFGSQHGQIFGLAAMPPI----NRRSATSTNLRPSSSASQRINSGSTIGGAVGNGSNTARS-- 791
            ......:..|......:||.    :.||.||....|.|.:...::||........:.:...|.
Human   687 MQALAEEDLQHLPPQPLPPQLSQGDGRSETSQPPTPGSPSHSPLHSGPRPRRRESDPTGPQRQVF 751

  Fly   792 SVAGDHSVTQFA---------------LID-DENVSALQQVTKGG---------ALTLA------ 825
            |||....|....               |.| .|....|.:|.:.|         .:.||
Human   752 SVAPPFEVNGLPRAVPLSLPYQDFKRDLSDYRERARLLNRVRRVGFSHMLLTTPQVPLAPVQPQA 816

  Fly   826 ----SQWKSQFDDSEDTTDNEWNREHQLQPNLEQLIKLD-----ISLPLNEAKPFPQHGVAGTGK 881
                .:.:.:.|:.|:..|.|...|.:.:...|:..:.:     .::.|.|... |:.|.:..|.
Human   817 NGKEEEEEEEEDEEEEEEDEEEEEEEEEEEEEEEEEEEEEEEAAAAVALGEVLG-PRSGSSSEGS 880

  Fly   882 ---------------LINPPGEAKGRPKRYTLNITGIENYEALRISIPNCWS----------EPA 921
                           |.:...|::||......::...|..:.|.:..|....          :|.
Human   881 ERSTDRSQEGAPSTLLADDQKESRGRASMADGDLEPEEGSKTLVLVSPGDMKKSPVTAELAPDPD 945

  Fly   922 MGNVLRKGLEPPAVQQAAFDDTVYRMDIARNVCVRETYSEITHLARPST-SSVLRNRLPSPFKKD 985
            :|.:  ..|.|   |......|..::|:                :.|.| ||||::. |.|....
Human   946 LGTL--AALTP---QHERPQPTGSQLDV----------------SEPGTLSSVLKSE-PKPPGPG 988

  Fly   986 SALQLNSTNDSLDKSRHRNSLPNVSVNDIFDDLQMKLNLDL----GSAIQENNCCISGRLEIRV- 1045
            :.|...:....:......:| |...|...|..:..|.:|::    |.|::.......|.|.:.:
Human   989 AGLGAGTVTTGVGGVAVTSS-PFTKVERTFVHIAEKTHLNVMSSGGQALRSEEFSAGGELGLELA 1052

  Fly  1046 -----IPKDTSHPDDS-----------VYYDAM-GAVKNTPTANEGHDHSDQAVNN-------CD 1086
                 :.:....|.::           :...|: ||.:.||        |:.|.|:       .|
Human  1053 SDGGAVEEGARAPLENGLALSGLNGAEIEGSALSGAPRETP--------SEMATNSLPNGPALAD 1109

  Fly  1087 EMEATSAVIAFPNKSISKIMSP-----PGRD--------ATEERTGASLCSLYSA---------- 1128
            .....|.:...|.|..:  :||     ||..        .:||.||:......||
Human  1110 GPAPVSPLEPSPEKVAT--ISPRRHAMPGSRPRSRIPVLLSEEDTGSEPSGSLSAKERWSKRARP 1172

  Fly  1129 -------------GVNKLKL-NGNTAPRTQFKKGSTDGFGENESEFDFPLLNPSKIPVRQSKCAS 1179
                         |...|:| :|.::..::.::.:::......||.|.|...|:....|:|   .
Human  1173 QQDLARLVMEKRQGRLLLRLASGASSSSSEEQRRASETLSGTGSEEDTPASEPAAALPRKS---G 1234

  Fly  1180 WAGADFISASKPLESAEVPQEIPYHPQSDTTYSVIDSIPVRKTTYSIALECPP---NISDLTP-- 1239
            .|.|......:|: ...:|..:.....:..::....::....|:..:.|:.||   ..:||.|
Human  1235 RAAATRSRIPRPI-GLRMPMPVAAQQPASRSHGAAPALDTAITSSRLQLQTPPGSATAADLRPKQ 1298

  Fly  1240 ------GLRRRRESTEGKYVTDPTQLPLKFQ-------RPRSRTSSR----------------TR 1275
                  |..|.:..........| :||....       .|||::.||                .|
Human  1299 PPGRGLGPGRAQAGARPPAPRSP-RLPASTSAARNASASPRSQSLSRRESPSPSHQARPGVPPPR 1362

  Fly  1276 GIPNAMLE----------NSDDNGTVMSAEKTGHGHVVKTEG 1307
            |:|.|..:          .....|.:.:...|..|.....||
Human  1363 GVPPARAQPDGTPSPGGSKKGPRGKLQAQRATTKGRAGGAEG 1404

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Asator	NP_651924.2	STKc_TTBK	172..433	CDD:270919	203/260 (78%)
		S_TKc	173..414	CDD:214567	194/240 (81%)
TTBK1	XP_016866853.1	None

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	393	1.000	Domainoid score	I774
eggNOG	1	0.900	-	-		E1_KOG1164
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0002285
OrthoInspector	1	1.000	-	-		otm42071
orthoMCL	1	0.900	-	-		OOG6_101431
Panther	1	1.100	-	-	O	PTHR11909
Phylome	0	0.000	Not matched by this tool.
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R3595
SonicParanoid	1	1.000	-	-		X1513
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	9	8.930