DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Asator and VRK3

DIOPT Version :9

Sequence 1:	NP_651924.2	Gene:	Asator / 43794	FlyBaseID:	FBgn0039908	Length:	1349	Species:	Drosophila melanogaster
Sequence 2:	NP_057524.3	Gene:	VRK3 / 51231	HGNCID:	18996	Length:	474	Species:	Homo sapiens

Alignment Length:	499	Identity:	107/499 - (21%)
Similarity:	182/499 - (36%)	Gaps:	151/499 - (30%)

- Green bases have known domain annotations that are detailed below.

  Fly    19 DGNQSCQPSSKQDQYLSPNRNCQKNLLRLYPPPPSKPPPLVGAILQTRLLHQI---SPSAIADAD 80
            ||:     ||:.:..||.:...:.:..|  ||.|...|.      :||...|:   ||
Human    79 DGD-----SSESEDTLSSSERSKGSGSR--PPTPKSSPQ------KTRKSPQVTRGSP------- 123

  Fly    81 ADLNAVGELLYPNVLQRSATLPAKHNRLG---VRSRVTFK---VPSSNLPAQDSYSHQPRNQVAV 139
                           |:::..|.|..:..   .|||||..   :|:..:....|...........
Human   124 ---------------QKTSCSPQKTRQSPQTLKRSRVTTSLEALPTGTVLTDKSGRQWKLKSFQT 173

  Fly   140 AAKDGILVDV-------------KAKESVKMTSEDLLQPGHVVKERWKVVRKIGGGGFGEIYEGQ 191
            ....|||.:.             |.|.|:|:.::|                       |.::..|
Human   174 RDNQGILYEAAPTSTLTCDSGPQKQKFSLKLDAKD-----------------------GRLFNEQ 215

  Fly   192 DLITREQVALKVESARQPKQVLKMEVAVLKKLQGKE----HVCRFIGCGRNDRFNYVVMQLQGKN 252
            :...|         |.:|.||.|.     |||....    ..|...|. ..|::.::|:...|::
Human   216 NFFQR---------AAKPLQVNKW-----KKLYSTPLLAIPTCMGFGV-HQDKYRFLVLPSLGRS 265

  Fly   253 LAELRRAQPRGAFSLSTTLRLGLQILKAIESIHSVGFLHRDIKPSNFSVGRLPYNCRRVYMLDFG 317
            |.......|:...|..:.|::..::|.|:|.:|...::|.::...|..|.  |.:..:|.:..:|
Human   266 LQSALDVSPKHVLSERSVLQVACRLLDALEFLHENEYVHGNVTAENIFVD--PEDQSQVTLAGYG 328

  Fly   318 LARQYTTGTGEVRCPRA-----AAGFR----GTVRYASINAHRNREMGRHDDLWSLFYMLVEFVN 373
            .|.:|        ||..     ..|.|    |.:.:.|::.|:.....|..||.||.|.:::::.
Human   329 FAFRY--------CPSGKHVAYVEGSRSPHEGDLEFISMDLHKGCGPSRRSDLQSLGYCMLKWLY 385

  Fly   374 GQLPWRK-IKDKEQVGLTKEKY-----------DHRILLKHLPSD-LKQFLEHIQSLTYGDRPDY 425
            |.|||.. :.:.|.:...|:|:           .|.|    .||: |:::|:.:.:|||.::|.|
Human   386 GFLPWTNCLPNTEDIMKQKQKFVDKPGPFVGPCGHWI----RPSETLQKYLKVVMALTYEEKPPY 446

  Fly   426 AMLIGLFERCMKRRGVKESDPYDWEKVDSTAIGNISATGNPSIP 469
            |||....|..::...|...||                .|.|.:|
Human   447 AMLRNNLEALLQDLRVSPYDP----------------IGLPMVP 474

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Asator	NP_651924.2	STKc_TTBK	172..433	CDD:270919	66/286 (23%)
Asator	NP_651924.2	S_TKc	173..414	CDD:214567	58/266 (22%)
VRK3	NP_057524.3	zinc_ribbon_2	4..26	CDD:289981
		DZR	5..>31	CDD:289539
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	41..152		24/107 (22%)
		Nuclear localization signal. /evidence=ECO:0000269\|PubMed:14645249	49..64
		DUF4551	<82..>150	CDD:291746	22/97 (23%)
		PKc_like	155..457	CDD:304357	76/353 (22%)
		SPS1	211..>467	CDD:223589	67/284 (24%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG1164
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.810