DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Asator and Ttbk1

DIOPT Version :9

Sequence 1:	NP_651924.2	Gene:	Asator / 43794	FlyBaseID:	FBgn0039908	Length:	1349	Species:	Drosophila melanogaster
Sequence 2:	XP_038939445.1	Gene:	Ttbk1 / 316229	RGDID:	1559518	Length:	1400	Species:	Rattus norvegicus

Alignment Length:	1489	Identity:	421/1489 - (28%)
Similarity:	624/1489 - (41%)	Gaps:	432/1489 - (29%)

- Green bases have known domain annotations that are detailed below.

  Fly   152 KESVKMT----SEDLLQPGHVVKERWKVVRKIGGGGFGEIYEGQDLITREQVALKVESARQPKQV 212
            |:...|:    ..|:|...:|||:||||::||||||||||||..||:|||.||||||||:|||||
  Rat     9 KDETNMSGGGEQADILPANYVVKDRWKVLKKIGGGGFGEIYEAMDLLTRENVALKVESAQQPKQV 73

  Fly   213 LKMEVAVLKKLQGKEHVCRFIGCGRNDRFNYVVMQLQGKNLAELRRAQPRGAFSLSTTLRLGLQI 277
            ||||||||||||||:|||||||||||::||||||||||:|||:|||:||||.|:||||||||.||
  Rat    74 LKMEVAVLKKLQGKDHVCRFIGCGRNEKFNYVVMQLQGRNLADLRRSQPRGTFTLSTTLRLGKQI 138

  Fly   278 LKAIESIHSVGFLHRDIKPSNFSVGRLPYNCRRVYMLDFGLARQYTTGTGEVRCPRAAAGFRGTV 342
            |::||:||||||||||||||||::||||...|:.||||||||||||..||:||.||..|||||||
  Rat   139 LESIEAIHSVGFLHRDIKPSNFAMGRLPSTYRKCYMLDFGLARQYTNTTGDVRPPRNVAGFRGTV 203

  Fly   343 RYASINAHRNREMGRHDDLWSLFYMLVEFVNGQLPWRKIKDKEQVGLTKEKYDHRILLKHLPSDL 407
            ||||:|||:||||||||||||||||||||..|||||||||||||||:.||||:||:||||:||:.
  Rat   204 RYASVNAHKNREMGRHDDLWSLFYMLVEFAVGQLPWRKIKDKEQVGMIKEKYEHRMLLKHMPSEF 268

  Fly   408 KQFLEHIQSLTYGDRPDYAMLIGLFERCMKRRGVKESDPYDWEKVDSTAIGNISATGNPSIPIKS 472
            ..||:||.||.|..:|||.:::.:||..||.||:.|::.:||||..:.|:.:.|.:..|....:.
  Rat   269 HLFLDHIASLDYFTKPDYQLIMSVFENSMKERGIAENEAFDWEKAGTDALLSTSTSTPPQQNTRQ 333

  Fly   473 DYMHGNITQMTVAASNASGTEYIRKRAE--IETAHITATDPLNIKEKVDKNCNATSL--AQPAK- 532
            ......:..:|....     :.:|:..|  ::..|::..:            ||..:  .:|.:
  Rat   334 TAAMFGVVNVTPVPG-----DLLRENTEDVLQGEHLSDQE------------NAPPILPGRPPEG 381

  Fly   533 -GSGEPMVQHGNAANNQNITSKGLQQQSTLTNSQVAIANIQSAPSMIEREDVQYTKLEEGAPTKF 596
             |.|..:|.|......:      :.:::.:..:::.| ||...| .:|.|..:..    |.|:..
  Rat   382 LGPGPHLVPHPGGPEAE------VWEETDVNRNKLRI-NIGKTP-CVEEEQSRGV----GVPSSP 434

  Fly   597 ITMKPNG----------------ECDNVDIAAKCIFEQKHVEANDDIVGRAS------------- 632
            :...|:.                |.:.:..||....|.:...:..|:.|..|
  Rat   435 VRAPPDSPTTPVRSLRYRRVNSPESERLSTAADGRAELQERRSRMDLPGSPSRQACSSQPAQMLS 499

  Fly   633 ---------LSG-------VEQHYKS---------QIKKHNSPE--IANKQIQ----------RT 660
                     .||       |||...|         :.:..:|.|  |.:|:.:          .|
  Rat   500 VDTGHADRQASGRMDVSASVEQEALSNAFRSVPLAEEEDFDSKEWVIIDKETELKDFPPGAEPST 564

  Fly   661 GTVTNDKTSEVNRSTEEQKSTFGRLRVLTAPPMSVHDLPSGGGHSHQVSDLSGKQDPYAATSNAA 725
            ...|:::..|:....||.:.   |.|:.|.|.:.    |.|.|     .....::||.......|
  Rat   565 SGTTDEEPEELRPLPEEGEE---RRRLGTEPTVR----PRGRG-----MQTLAEEDPRQMLPQPA 617

  Fly   726 PIGINSSSTKFGSQHGQIFGLAAMPPIN------RRSATST-----------------NLRPSSS 767
            |..::.:..:..:......|..:..|::      ||.:..|                 ...|...
  Rat   618 PPQLSQADGRSETSQPPTPGSPSHSPLHSGPRPRRRESDPTGPQRQLEEDRLSGHSLPRYSPLRR 682

  Fly   768 ASQRINSGSTI----------GGAVGNG------SNTARSS------------VAGDHSVTQFAL 804
            .:..:.|.||:          ||:.|:.      |.:|.||            .||:|.:....|
  Rat   683 LASSVFSSSTLETEHYPHPGGGGSSGSSGSLIQRSRSAESSPVRAPHRRHAPLAAGNHRLVPSVL 747

  Fly   805 --------------------------------------IDD--ENVSALQQVTKGG--------- 820
                                                  :.|  |....|.:|.:.|
  Rat   748 RISRSQLQQVFSVAPPFEVNGLPRAVPLGLPYQDFKRDLSDYRERARLLNRVRRVGFSHMLLTTP 812

  Fly   821 ALTLA-----SQWKSQFDDSEDTTDNEWNREHQLQPNLEQLIKLDISLPLNEAKPF-----PQHG 875
            .:.||     :..|...::.|:..:.|...|.:.:.:.|:..:.|......||...     |:.|
  Rat   813 QVPLAPFQPQANGKEGEEEEEEDEEEEEEEEEEDEEDEEEEDEEDEDEEEEEAGALGEVLGPRSG 877

  Fly   876 VAGTGK-----------LINPPGEAKGRPKRYTLNITGIENYEALRISIPNCWS----------E 919
            .:..|.           |.:...||:||......::...|..:.|.:..|....          :
  Rat   878 SSSEGSERSQEGAPSTLLADDQKEARGRASMADGDLEPEEGSKTLVLVSPGDMKKSPVTAELAPD 942

  Fly   920 PAMGNVLRKGLEPPAVQQAAFDDTVYRMDIARNVCVRETYSEITHLARPST-SSVLRNR------ 977
            |.:|.:  ..|.|   |......|..::|:                :.|.| ||:|::.
  Rat   943 PDLGTL--AALTP---QHERPQPTGSQLDV----------------SEPGTLSSILKSEPKPSGP 986

  Fly   978 -----------------LPSPFKKDSALQLNSTNDSLDKSRHRNSL------PNVSVNDIFDDLQ 1019
                             :.|||.|     :..|...:.:..|.|.:      |.........:|.
  Rat   987 GAGVGVGLVAPGAGVTAVTSPFTK-----VERTFVHIAEKSHLNVMSSGGQAPRPEELSTGGELG 1046

  Fly  1020 MKLNLDLGSAIQ------EN-------------NCCISGRLEIRVIPKDTSHPDDSVYYDAMGAV 1065
            :::..::|:|.:      ||             :|.:||.      |.:|  |.:.|
  Rat  1047 LEMLSEVGAAEEGAPQPLENGMALVGPDGTEMESCALSGP------PGET--PSEVV-------- 1095

  Fly  1066 KNTPTANEGHDHSDQAVNNCDEMEATSAVIAFPNKSISK---IMSP-----PGRD--------AT 1114
              |.:..:|...:|:...            |.|.:.|:|   |:||     ||..        .:
  Rat  1096 --TDSLPDGPALADEPAP------------ASPQEPITKKGTIISPSRHAMPGSRPRSRIPVLLS 1146

  Fly  1115 EERTGASLCSLYSA-----------------------GVNKLKL-NGNTAPRTQFKKGSTDGFGE 1155
            ||.||:......||                       |...|:| :|.::..::.::.:::....
  Rat  1147 EEDTGSEPSGSLSAKERWSKRARPQQDLARLVMEKRQGRLLLRLASGASSSSSEEQRRASETLSG 1211

  Fly  1156 NESEFDFPLLNPSKIPVRQSKCASWAGADF---ISASKPLESAEVPQEIPYHPQSDTTYSVIDSI 1217
            ..||.|.|...|:....|::..|:...:..   ||.|.|.|..::|.. | |..:..|.|.|
  Rat  1212 TGSEEDTPASEPAAALPRKAGRAATTRSRIPRPISVSMPAEGQQLPGR-P-HGAASATDSAI--- 1271

  Fly  1218 PVRKTTYSIALECPPNI---SDLTPGLRRRRESTEGK-YVTDPTQLPLKFQRPRSRTSSRTRGIP 1278
                 |..:.|:.||.:   :|..|.....|.|..|: .|:.|             .:.|:.|:|
  Rat  1272 -----TSRLQLQKPPGLATAADHRPKQPASRASGPGRAQVSKP-------------AAPRSPGLP 1318

  Fly  1279 NAMLENSDDNGTVMS---AEKTGHGHVVKTEGVKNFTTSENSSEVNPKCTISPPPGDPK 1334
            .:...:|..:....|   .|.:...|..:    ..|..|....:|..:...|  ||.||
  Rat  1319 TSTARHSSGSPRSQSLSRKESSSPSHQAR----PGFPPSRGVLQVRSQSEAS--PGGPK 1371

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Asator	NP_651924.2	STKc_TTBK	172..433	CDD:270919	203/260 (78%)
Asator	NP_651924.2	S_TKc	173..414	CDD:214567	194/240 (81%)
Ttbk1	XP_038939445.1	PKc_like	33..294	CDD:419665	203/260 (78%)
		PHA03307	324..>686	CDD:223039	60/402 (15%)
		PHA03307	1055..>1397	CDD:223039	76/376 (20%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	393	1.000	Domainoid score	I744
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0002285
OrthoInspector	1	1.000	-	-		otm46217
orthoMCL	1	0.900	-	-		OOG6_101431
Panther	1	1.100	-	-	O	PTHR11909
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X1513
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	9	8.910