DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Asator and Ttbk2

DIOPT Version :9

Sequence 1:	NP_651924.2	Gene:	Asator / 43794	FlyBaseID:	FBgn0039908	Length:	1349	Species:	Drosophila melanogaster
Sequence 2:	NP_542966.2	Gene:	Ttbk2 / 140810	MGIID:	2155779	Length:	1312	Species:	Mus musculus

Alignment Length:	1349	Identity:	425/1349 - (31%)
Similarity:	594/1349 - (44%)	Gaps:	280/1349 - (20%)

- Green bases have known domain annotations that are detailed below.

  Fly   161 DLLQPGHVVKERWKVVRKIGGGGFGEIYEGQDLITREQVALKVESARQPKQVLKMEVAVLKKLQG 225
            |:|..|.:|||||||:||||||||||||:..|::|||.||||||||:||||||||||||||||||
Mouse    78 DILSVGILVKERWKVLRKIGGGGFGEIYDALDMLTRENVALKVESAQQPKQVLKMEVAVLKKLQG 142

  Fly   226 KEHVCRFIGCGRNDRFNYVVMQLQGKNLAELRRAQPRGAFSLSTTLRLGLQILKAIESIHSVGFL 290
            |:|||||||||||||||||||||||:|||:|||:|.||.|::|||||||.|||::||||||||||
Mouse   143 KDHVCRFIGCGRNDRFNYVVMQLQGRNLADLRRSQSRGTFTISTTLRLGKQILESIESIHSVGFL 207

  Fly   291 HRDIKPSNFSVGRLPYNCRRVYMLDFGLARQYTTGTGEVRCPRAAAGFRGTVRYASINAHRNREM 355
            |||||||||::||.|..||:.:|||||||||:|...|:||.|||.||||||||||||||||||||
Mouse   208 HRDIKPSNFAMGRFPSTCRKCFMLDFGLARQFTNSCGDVRPPRAVAGFRGTVRYASINAHRNREM 272

  Fly   356 GRHDDLWSLFYMLVEFVNGQLPWRKIKDKEQVGLTKEKYDHRILLKHLPSDLKQFLEHIQSLTYG 420
            |||||||||||||||||.|||||||||||||||..||:||||::|||||.:...||:||.||.|.
Mouse   273 GRHDDLWSLFYMLVEFVVGQLPWRKIKDKEQVGSIKERYDHRLMLKHLPPEFSTFLDHISSLDYF 337

  Fly   421 DRPDYAMLIGLFERCMKRRGVKESDPYDWEKVDSTAIGNISATGNPSIPIKSDYMHGNITQMTVA 485
            .:|||.:|..:|:..:|..||.||||:||||  |...|:::.|...:.|    .:|..:|...:.
Mouse   338 TKPDYQLLTSVFDNSIKTFGVIESDPFDWEK--SGTDGSLTTTTTSATP----QLHTRLTPAAIG 396

  Fly   486 ASNASGT--EYIRKRAEIETAHITATDPLNIKEKVDKNCNATSL-AQPAK--GS-GEPMVQHGNA 544
            .:||:..  :.:|:.          ||.:...|::....|...: ..|.|  || |.|..|..:.
Mouse   397 IANATPIPGDLLREN----------TDEVFPDEQLSDGENGIPVGVSPDKLPGSLGHPRPQEKDV 451

  Fly   545 AN----NQNITSKGLQQQST-LTNSQVAIANIQSAPSMIE--REDVQYTKLEEGAP--------- 593
            ..    |:|....|:.:.:| ..||...:..|.:|||:..  |...:.|:.:...|
Mouse   452 WEEMDINKNKIKLGICKAATEEENSHGQVNGILNAPSLGSPIRVRSEITQPDRDVPLVRKLRSIH 516

  Fly   594 ----TKFITMKPNGECDNVDIAAKCIFEQKHVEANDDIVGRASLSGVEQ---------------- 638
                .|.:|::|..:.|            |.:|...:.:.:.|.:|.|.
Mouse   517 SFELEKRLTLEPKPDTD------------KFLETCMEKMQKDSSAGKEPVPPALPHKPCVPVVTH 569

  Fly   639 -----HYKSQ-IKKHNSPEIANKQIQRTGTVTNDKTSEVNRSTEEQKSTFGRLRVLTAPPMSVHD 697
                 ||..: :...:.|..||...|..|..:|...: ||.|:.:|: ...:..|:......:.|
Mouse   570 TDHIWHYDDEYLPDASKPASANTPEQADGGGSNGFIA-VNLSSCKQE-VDSKEWVIVDKEQDLQD 632

  Fly   698 LPSGGGHSHQVSDLSGKQDPYA----------ATSNAAPIGINSSSTKFGSQHGQIFGLAAMPPI 752
            ..:.....|:.:.....::|..          ......|...|....|..|  |.:..|:|..|.
Mouse   633 FRTNEVLGHKTTGSPSDEEPEVLQVLEGSPQDEKIQVGPWTDNHHLKKESS--GVVLALSAECPA 695

  Fly   753 NRRSATSTNL--RPSSSASQRINSGSTIG-GAVGNGSNTA----RSSVAGDHSV----------- 799
            ...|...|:.  ..:.:|||.|....|.. .|...|..||    |.|||...|.
Mouse   696 TAASELYTDRLDLQAGAASQFITVTPTSPMEAQAEGPLTAITIPRPSVASTQSTSGSFHYGPQPE 760

  Fly   800 ---------TQFALIDDENVSALQQVTKGGALTLASQWKS-----QFDDSEDTTDNEWNREHQLQ 850
                     |.......||.|.| .||:|   .|||....     |.|          :..|.:.
Mouse   761 KKDLQPLEPTVELYSPRENFSGL-VVTEG---ELASGGSRVDLGLQID----------HTGHDML 811

  Fly   851 PNLEQLIKLDISLPLNEAKPFPQHGVAGTGKLINPPGEAKGRPKRYTLNITGIENYEALRISIPN 915
            ||:..   .|.|..|....| |.|......:..:.|||.:.|..     :.|.||.:.......:
Mouse   812 PNMRD---GDTSQDLGPKDP-PDHNRLAVKEFEHLPGETEERSL-----LLGSENEDERLSKGQH 867

  Fly   916 CWSEPAMGNVLRKGLEPPAVQQAAFDDTVYRMDIARNVCVRETYSEITHLARPSTSSVLRNRLPS 980
            |....:.|.::                |..|..:|.        :|..|::.....|||.|:
Mouse   868 CIEVSSPGELV----------------TAERAQLAA--------TEPLHVSETQNCSVLPNQ--- 905

  Fly   981 PFKKDSALQLNSTNDSLDKSRHRNSLPNVSVNDIFD---DLQMKLNLDLGSAIQENNCCISGRLE 1042
                             ||:.....|..|..::|..   |...:..:...:|:|:|.......::
Mouse   906 -----------------DKTHEIMKLLAVGTSEISPQAIDPHAEGQIGQMAAMQKNKLFKDDGIQ 953

  Fly  1043 IRVIPK---DTS---H---------PDDSVYYDAMGAVKNTPTANEG---------HDHSDQAVN 1083
            ...:|:   |.|   |         |.:...|..:...::.|...:.         |........
Mouse   954 SESLPRQQGDLSAFLHQEGKREKVVPRNGELYHCVSENEHGPPTRKDMLRSSFVTRHSRIPVLAQ 1018

  Fly  1084 NCDEMEATSAVIAFPNKSISKIMSPPG--RDATEERTGASLCSLYSAGVNKL---KLNGNTAPRT 1143
            ..|....:|:.|:...|.:.|....|.  :...|:|...|.....|:..:||   ||.....|.:
Mouse  1019 EIDSTFESSSAISAKEKLLQKKAYQPEIVKLLVEKRQFKSFLGDLSSASDKLIEEKLAAVPVPFS 1083

  Fly  1144 Q------FKKGSTDGFGENESEFDF--PLLN---PSKIPVRQSKCASWAGADFISASKPLESAEV 1197
            :      |.:.:.|.......|..|  |:::   .||||    :..||...|.|:.|..
Mouse  1084 EEEVFAPFSRLAADSHLSRSVEDSFLSPIISQARKSKIP----RPVSWVSTDQINGSAS------ 1138

  Fly  1198 PQEIPYHPQSDTTYSVIDSIPVRKTTYSIALECPPNISD--------LTPGLRRRRESTEGKYVT 1254
            ||.:|..|....  .|...:..|...|.: |....:.||        |..|.::.|.:|:.|...
Mouse  1139 PQFLPRPPPGKP--PVRPGVEARLRRYKV-LGSSNSDSDLFSRLAQILQNGSQKSRSTTQCKSPG 1200

  Fly  1255 DP--TQLPLK---FQRPRSRTSSRTRGIPNAMLENSDDNGTVMSAEKTGHGHVVKTEGVKNFTTS 1314
            .|  .:.|.|   ..|.....|.|:..:|.....:....|.....:::...|:.:::...:.:.|
Mouse  1201 SPHNPKTPPKSPVVPRRSPSASPRSSSLPRTSSSSPSRAGRPHHDQRSSSPHLGRSKSPPSHSGS 1265

  Fly  1315 ENS-----------SEVNPK---------CTISPPPGDPKIENSARLRR 1343
            .:|           |:..||         .:...|||  |.:.:::|.|
Mouse  1266 SSSRRSCQQEHCKPSKNGPKGSGSLHHHSTSSKTPPG--KSKPASKLSR 1312

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Asator	NP_651924.2	STKc_TTBK	172..433	CDD:270919	204/260 (78%)
Asator	NP_651924.2	S_TKc	173..414	CDD:214567	194/240 (81%)
Ttbk2	NP_542966.2	STKc_TTBK2	89..350	CDD:271031	204/260 (78%)
Ttbk2	NP_542966.2	Pkinase	90..329	CDD:278497	193/238 (81%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167833628
Domainoid	1	1.000	393	1.000	Domainoid score	I772
eggNOG	1	0.900	-	-		E1_KOG1164
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0002285
OrthoInspector	1	1.000	-	-		otm44125
orthoMCL	1	0.900	-	-		OOG6_101431
Panther	1	1.100	-	-	LDO	PTHR11909
Phylome	0	0.000	Not matched by this tool.
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R3595
SonicParanoid	1	1.000	-	-		X1513
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	11	10.860