DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Asator and Ttbk1

DIOPT Version :9

Sequence 1:	NP_651924.2	Gene:	Asator / 43794	FlyBaseID:	FBgn0039908	Length:	1349	Species:	Drosophila melanogaster
Sequence 2:	NP_001156336.1	Gene:	Ttbk1 / 106763	MGIID:	2147036	Length:	1308	Species:	Mus musculus

Alignment Length:	1395	Identity:	409/1395 - (29%)
Similarity:	607/1395 - (43%)	Gaps:	347/1395 - (24%)

- Green bases have known domain annotations that are detailed below.

  Fly   152 KESVKMT----SEDLLQPGHVVKERWKVVRKIGGGGFGEIYEGQDLITREQVALKVESARQPKQV 212
            |:...|:    ..|:|...:|||:||||::||||||||||||..||:|||.||||||||:|||||
Mouse     9 KDETNMSGGGEQADILPANYVVKDRWKVLKKIGGGGFGEIYEAMDLLTRENVALKVESAQQPKQV 73

  Fly   213 LKMEVAVLKKLQGKEHVCRFIGCGRNDRFNYVVMQLQGKNLAELRRAQPRGAFSLSTTLRLGLQI 277
            ||||||||||||||:|||||||||||::||||||||||:|||:|||:||||.|:||||||||.||
Mouse    74 LKMEVAVLKKLQGKDHVCRFIGCGRNEKFNYVVMQLQGRNLADLRRSQPRGTFTLSTTLRLGKQI 138

  Fly   278 LKAIESIHSVGFLHRDIKPSNFSVGRLPYNCRRVYMLDFGLARQYTTGTGEVRCPRAAAGFRGTV 342
            |::||:||||||||||||||||::||||...|:.||||||||||||..||:||.||..|||||||
Mouse   139 LESIEAIHSVGFLHRDIKPSNFAMGRLPSTYRKCYMLDFGLARQYTNTTGDVRPPRNVAGFRGTV 203

  Fly   343 RYASINAHRNREMGRHDDLWSLFYMLVEFVNGQLPWRKIKDKEQVGLTKEKYDHRILLKHLPSDL 407
            ||||:|||:||||||||||||||||||||..|||||||||||||||:.||||:||:||||:||:.
Mouse   204 RYASVNAHKNREMGRHDDLWSLFYMLVEFAVGQLPWRKIKDKEQVGMIKEKYEHRMLLKHMPSEF 268

  Fly   408 KQFLEHIQSLTYGDRPDYAMLIGLFERCMKRRGVKESDPYDWEKVDSTAIGNISATGNPSIPIKS 472
            ..||:||.||.|..:|||.:::.:||..||.||:.|::.:||||..:.|:.:.|.:..|....:.
Mouse   269 HLFLDHIASLDYFTKPDYQLIMSVFENSMKERGIAENEAFDWEKAGTDALLSTSTSTPPQQNTRQ 333

  Fly   473 DYMHGNITQMTVAASNASGTEYIRKRAE--IETAHITATDPLNIKEKVDKNCNATSL--AQPAK- 532
            ......:..:|....     :.:|:..|  ::..|::..:            ||..:  .:|.:
Mouse   334 TAAMFGVVNVTPVPG-----DLLRENTEDVLQGEHLSDQE------------NAPPILPGRPPEG 381

  Fly   533 -GSGEPMVQHGNAANNQNITSKGLQQQSTLTNSQVAIANIQSAPSMIEREDVQYTKLEEGAPTKF 596
             |.|..:|.|......:      :.:::.:..:::.| ||...| .:|.|..:..    |.|:..
Mouse   382 LGPGPHLVPHPGGPEAE------VWEETDVNRNKLRI-NIGKTP-CVEEEQSRGV----GVPSSP 434

  Fly   597 ITMKPNG----------------ECDNVDIAAKCIFEQKHVEANDDIVGRAS------------- 632
            :...|:.                |.:.:..||....|.:...:..|:.|..|
Mouse   435 VRAPPDSPTTPVRSLCYRRVNSPESERLSTAADGRVELQERRSRMDLPGSPSRQACSSQPAQMLS 499

  Fly   633 ---------LSG-------VEQHYKS---------QIKKHNSPE--IANKQIQ----------RT 660
                     .||       |||...|         :.:..:|.|  |.:|:.:          .|
Mouse   500 VDTGHADRQASGRMDVSASVEQEALSNAFRSVPLAEEEDFDSKEWVIIDKETELKDFPPGAEPST 564

  Fly   661 GTVTNDKTSEVNRSTEEQKSTFGRLRVLTAPPMSVHDLPSGGGHSHQVSDLSGKQDPYAATSNAA 725
            ...|:::..|:....||.:.   |.|:.|.|.:.    |.|.| .|.:::    :||.......|
Mouse   565 SGTTDEEPEELRPLPEEGEE---RRRLGTEPTVR----PRGRG-MHTLTE----EDPRQMLPQPA 617

  Fly   726 PIGINSSSTKFGSQHGQIFGLAAMPPINRRSATSTNLRPSSSASQRINSGSTIGGAVGNGSNTAR 790
            |           .|..|..|         ||.||....|.|.:...::||........:.:...|
Mouse   618 P-----------PQLSQADG---------RSETSQPPTPGSPSHSPLHSGPRPRRRESDPTGPQR 662

  Fly   791 S--SVAGDHSV------TQFAL--------IDD--ENVSALQQVTKGG----ALTL--------- 824
            .  |||....|      ...||        :.|  |....|.:|.:.|    .||.
Mouse   663 QVFSVAPPFEVNGLPRAVPLALPYQDFKRDLSDYRERARLLNRVRRVGFSHMLLTAPQVPLAPFQ 727

  Fly   825 ----ASQWKSQFDDSEDTTDNEWNREHQLQPNLEQLIKLDISLPLNEAKPFPQHGVAGTGK---- 881
                ..:.:.:.::.|:..:.|...|.:.:...|:..:.:.:..|.|... |:.|.:..|.
Mouse   728 PQANGKEGEEEEEEEEEEEEEEEEEEEEEEEEEEEEEEEEEAGALGEVLG-PRSGSSSEGSERST 791

  Fly   882 -----------LINPPGEAKGRPKRYTLNITGIENYEALRISIPNCWS----------EPAMGNV 925
                       |.:...||:||......::...|..:.|.:..|....          :|.:|.:
Mouse   792 ERSQEGAPSTLLADDQKEARGRASMADGDLEPEEGSKTLVLVSPGDMKKSPVTAELAPDPDLGTL 856

  Fly   926 LRKGLEPPAVQQAAFDDTVYRMDIARNVCVRETYSEITHLARPST-SSVLRNR------------ 977
              ..|.|   |......|..::|:                :.|.| ||:|::.
Mouse   857 --AALTP---QHERPQPTGSQLDV----------------SEPGTLSSILKSEPKPSGPGAGGGV 900

  Fly   978 -----------LPSPFKK----------DSALQLNSTNDSLDKSRHRNS-----LPNVSVNDIFD 1016
                       :.|||.|          .|.|.:.|:.....:....::     |..:|...|.:
Mouse   901 GLVAPGAGVTAVTSPFTKVERTFVHIAEKSHLNVMSSGGQASRPEELSTGGELGLEVLSEGGIAE 965

  Fly  1017 DLQMKLNLDLGSAI------QENNCCISGRLEIRVIPKDTSHPDDSVYYDAMGAVKNTPTANEGH 1075
            : .....|:.|.|:      :..:|.:||.      |.:|  |.:.|    ..::.|.|...:|.
Mouse   966 E-GAPAPLENGMALAGLDGTEMESCALSGP------PGET--PSEVV----TDSLPNGPALADGP 1017

  Fly  1076 DHSDQAVNNCDEMEATSAVIAFPNKSISKIMSPPGRD---ATEERTGASLCSLYSA--------- 1128
            ..:.|     .|..........|::.......|..|.   .:||.||:......||
Mouse  1018 APASQ-----QEPVTKKGTTISPSRHAMPGSRPRSRIPVLLSEEDTGSEPSGSLSAKERWSKRAR 1077

  Fly  1129 --------------GVNKLKL-NGNTAPRTQFKKGSTDGFGENESEFDFPLLNPSKIPVRQSKCA 1178
                          |...|:| :|.::..::.::.:::......||.|.|...|:....|::..|
Mouse  1078 PQQDLARLVMEKRQGRLLLRLASGASSSSSEEQRRASETLSGTGSEEDTPASEPTTALPRKAVRA 1142

  Fly  1179 SWAGADF---ISASKPLESAEVPQEIPYHPQSDTTYSVIDSIPVRKTTYSIALECPPNISDLTPG 1240
            :...:..   ||.|.|:|..::|.. |:...|.|..::...:.::|.            |.|.|.
Mouse  1143 ATTRSRIPRPISVSMPVEGQQLPGR-PHGAASATDLAITSRLQLQKP------------SGLAPA 1194

  Fly  1241 --LRRRRESTEG-----KYVTDPTQLPLKFQRPRS-----RTSSRTRGIPNAMLENSDDNGTVMS 1293
              ||.::.::.|     ..|:.|.       .|||     .|:....|.|.:...:..::.:...
Mouse  1195 ADLRPKQSASRGPGPGRAQVSKPA-------APRSPGLPASTARHPSGSPRSQSLSRKESSSPSH 1252

  Fly  1294 AEKTGHGHVVKTEGVKNFTTSENSSEVNPK 1323
            ..:.|   |..:.||....:...:|.|.||
Mouse  1253 QARPG---VPPSRGVLQVRSQPEASPVAPK 1279

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Asator	NP_651924.2	STKc_TTBK	172..433	CDD:270919	203/260 (78%)
Asator	NP_651924.2	S_TKc	173..414	CDD:214567	194/240 (81%)
Ttbk1	NP_001156336.1	STKc_TTBK1	33..294	CDD:271032	203/260 (78%)
		PHA03307	324..>683	CDD:223039	71/419 (17%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	364..397		7/44 (16%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	418..448		6/34 (18%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	474..671		45/228 (20%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	720..899		29/200 (15%)
		PHA03307	963..>1305	CDD:223039	68/358 (19%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	985..1085		21/116 (18%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1097..1308		41/206 (20%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	393	1.000	Domainoid score	I772
eggNOG	1	0.900	-	-		E1_KOG1164
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0002285
OrthoInspector	1	1.000	-	-		otm44125
orthoMCL	1	0.900	-	-		OOG6_101431
Panther	1	1.100	-	-	O	PTHR11909
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R3595
SonicParanoid	1	1.000	-	-		X1513
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	11	10.840