DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Asator and Vrk3

DIOPT Version :9

Sequence 1:	NP_651924.2	Gene:	Asator / 43794	FlyBaseID:	FBgn0039908	Length:	1349	Species:	Drosophila melanogaster
Sequence 2:	NP_598706.1	Gene:	Vrk3 / 101568	MGIID:	2182465	Length:	453	Species:	Mus musculus

Alignment Length:	458	Identity:	94/458 - (20%)
Similarity:	174/458 - (37%)	Gaps:	96/458 - (20%)

- Green bases have known domain annotations that are detailed below.

  Fly    15 SAPDDGNQSCQPSSKQDQYLSPNRNCQKNLLRLYPPPPSKPPPLVGAILQTRLLHQISPSAIADA 79
            |.|...:..|..|...:...||:|   ....|..|..|...|          |.::.||..:.
Mouse    71 SLPLSRHSDCDSSGSDNTLTSPDR---ATGTRSRPLTPKGSP----------LSNRQSPQTLK-- 120

  Fly    80 DADLNAVGELLYPNVLQRSATLPAKHNRLGVRSRVTFKVPS----SNLPAQDSYSHQPRNQVAVA 140
                                           |:|||..:.:    :.|..|:. .|.....:.:.
Mouse   121 -------------------------------RTRVTTSLQALATGTELTDQNG-KHWTLGALQIR 153

  Fly   141 AKDGILVDVKAKESVKMTSEDLLQPGHVVKERWKVVRKIGGGGFGEIYEGQDLITREQVALKVES 205
            ...|||.:.:...:|         |.....::|:...|:.... |.::..|:...|  ||..::.
Mouse   154 DDQGILYEAEPTSAV---------PSESRTQKWRFSLKLDSKD-GRLFNEQNFFQR--VAKPLQV 206

  Fly   206 ARQPKQVLKMEVAVLKKLQGKEHVCRFIGCG-RNDRFNYVVMQLQGKNLAELRRAQPRGAFSLST 269
            .:..||.|...:|:        ..|  ||.| ..|::.::|....|::|.......|:...|...
Mouse   207 NKWKKQFLLPLLAI--------PTC--IGFGIHQDKYRFLVFPSLGRSLQSALDDNPKHVVSERC 261

  Fly   270 TLRLGLQILKAIESIHSVGFLHRDIKPSNFSVGRLPYNCRRVYMLDFGLARQYTTGTGEV----- 329
            .|::..::|.|:|.:|...::|.::...|..|.  |.:..:|.::.:|...:|..|...|
Mouse   262 VLQVACRLLDALEYLHENEYVHGNLTAENVFVN--PEDLSQVTLVGYGFTYRYCPGGKHVAYKEG 324

  Fly   330 -RCPRAAAGFRGTVRYASINAHRNREMGRHDDLWSLFYMLVEFVNGQLPWRK-IKDKEQVGLTKE 392
             |.|.     .|.:.:.|::.|:.....|..||.:|.|.:::::.|.|||.. :.:.|::...|:
Mouse   325 SRSPH-----DGDLEFISMDLHKGCGPSRRSDLQTLGYCMLKWLYGSLPWTNCLPNTEKITRQKQ 384

  Fly   393 KY---DHRIL-----LKHLPSDLKQFLEHIQSLTYGDRPDYAMLIGLFERCMKRRGVKESDPYDW 449
            ||   ..|::     .......|:::|:.:.:|.|.::|.||.|....|..::...|...||.|.
Mouse   385 KYLDSPERLVGLCGRWNKASETLREYLKVVMALNYEEKPPYATLRNSLEALLQDMRVSPYDPLDL 449

  Fly   450 EKV 452
            :.|
Mouse   450 QMV 452

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Asator	NP_651924.2	STKc_TTBK	172..433	CDD:270919	62/276 (22%)
Asator	NP_651924.2	S_TKc	173..414	CDD:214567	56/256 (22%)
Vrk3	NP_598706.1	zinc_ribbon_2	4..26	CDD:379084
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	30..123		15/97 (15%)
		Nuclear localization signal. /evidence=ECO:0000269\|PubMed:14645249	49..64
		PKc_like	134..436	CDD:389743	71/331 (21%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG1164
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.810