Protein Alignment Asator and ttbk2a

DIOPT Version :10

• Sequence 1: NP_651924.2
• Gene: Asator / 43794
• FlyBaseID: FBgn0039908
• Length: 1349
• Species: Drosophila melanogaster
• Sequence 2: XP_002665285.3
• Gene: ttbk2a / 100331590
• ZFINID: ZDB-GENE-120928-3
• Length: 1193
• Species: Danio rerio
• Alignment Length: 1301
• Identity: 395/1301 - (30%)
• Similarity: 534/1301 - (41%)
• Gaps: 365/1301 - (28%)

  Fly   161 DLLQPGHVVKERWKVVRKIGGGGFGEIYEGQDLITREQVALKVESARQPKQVLKMEVAVLKKLQG 225
            |:|..|.:||||||:::||||||||||||..||:||..||||.|||:||||||||||||||||||
Zfish     9 DILSTGILVKERWKILKKIGGGGFGEIYEALDLMTRTSVALKAESAQQPKQVLKMEVAVLKKLQG 73

  Fly   226 KEHVCRFIGCGRNDRFNYVVMQLQGKNLAELRRAQPRGAFSLSTTLRLGLQILKAIESIHSVGFL 290
            |:|||||:|||||||||||||:|||:|||:|||:..||.|::|||||||||||:|||||||||||
Zfish    74 KDHVCRFVGCGRNDRFNYVVMELQGRNLADLRRSMNRGTFTVSTTLRLGLQILEAIESIHSVGFL 138

  Fly   291 HRDIKPSNFSVGRLPYNCRRVYMLDFGLARQYTTGTGEVRCPRAAAGFRGTVRYASINAHRNREM 355
            |||||||||::||.|..||..||||||||||:|....|||.||..|||||||||||||||:|:||
Zfish   139 HRDIKPSNFAMGRFPSTCRTCYMLDFGLARQFTNSCQEVRPPRPVAGFRGTVRYASINAHKNKEM 203

  Fly   356 GRHDDLWSLFYMLVEFVNGQLPWRKIKDKEQVGLTKEKYDHRILLKHLPSDLKQFLEHIQSLTYG 420
            ||||||||||||||||:.|||||||||||||||..||.||||::|||||.....||:||.:|.|.
Zfish   204 GRHDDLWSLFYMLVEFLVGQLPWRKIKDKEQVGKLKETYDHRLMLKHLPPQFTVFLDHISNLDYF 268

  Fly   421 DRPDYAMLIGLFERCMKRRGVKESDPYDWEKVDSTAIGNISATGNPSIPIKSDYMHGNITQMTVA 485
            .:|||.:|..:||..|:...|.|:||||||::.|.                        :.||:.
Zfish   269 TKPDYQLLRTVFENSMRTYNVVENDPYDWERISSD------------------------SPMTIT 309

  Fly   486 ASNASGTEYIRKRAEIETAHITATDPLNIKEKVDKNCNATSLAQPAKGSGEPMVQHGNAANNQNI 550
            |                    ||..|
Zfish   310 A--------------------TANTP--------------------------------------- 315

  Fly   551 TSKGLQQQSTLTNSQVAIANIQSAPSMIEREDVQYTKLEEGAPTKFITMKPNGECDNVDIAAKCI 615
                 |..:.||.:|:.|.|....|..:.:|:.     ||....:.::...|...:|:..:.|..
Zfish   316 -----QHHTRLTPAQMGIINNSLVPGDLLKENT-----EEVLQDEHLSDGDNPRPENLLGSPKLP 370

  Fly   616 FEQKHVEANDDI------VGRASLS-GVEQHYKSQIKK--HNSPEIANKQIQRTGTVTNDKTSEV 671
            ...:.::..:|:      :..|.|. |.:..:.:|..:  |..|.|.:....|:..|.:|:.:.:
Zfish   371 LRNQEIDVWEDLDRNRNRISPAVLKIGTDDEHSNQGNQSPHAGPSIGSPVRVRSELVPSDRDTPL 435

  Fly   672 NRSTEEQKSTFGRLRVLTAPPMSVHDLPSGGGHSHQVSDLSGKQDPYAATSNAAPIGINSSSTKF 736
            .|......| |...:.||..|..        .....|...||||.|..|....|. |:...:...
Zfish   436 LRKLRNIHS-FELEKRLTLEPKP--------NTERFVEACSGKQPPGTAQERCAD-GVPGMAISN 490

  Fly   737 GSQHGQIFGLAAMPPINR-----RSATSTNLRPSSSASQRINSGSTIGGAVGNGSNTARSSVAGD 796
            ||            |..|     ....|.:.:|:|..|.....|:...|.|      ..||...|
Zfish   491 GS------------PTERVWHYDEEFRSGSPKPASPGSPEQGDGAANSGFV------HLSSGLQD 537

  Fly   797 HSVTQFALIDDENVSALQQVTKGGALT---LASQWKSQFDDSEDTTDNEWNREHQLQP------- 851
            ..:..:.:|  |.||.||...:....:   :|....|..::.|:..:       .|||
Zfish   538 VELRDWVMI--EKVSDLQDFKESAGSSPGHVAKLTNSPSEECEEEPE-------VLQPMDESPDK 593

  Fly   852 -NLEQLIKLDISLPLNEAKP----------FPQHGVAGTGKLINP--PGEAKGRPKRYTLNITGI 903
             :....::.||.:......|          ||..|    |..:.|  ||||..
Zfish   594 ESTPSAVQADIHMSHTVLSPQRMDRLELSVFPGSG----GPPVTPTSPGEALA------------ 642

  Fly   904 ENYEALRISIPNCWSEPAMGNVLRKGLEPPAVQQAAFDDTVYRMDIARNVCVRETYSEITHLARP 968
               |.....:|.                .||.|....        :||........|...|....
Zfish   643 ---EGALTQLPT----------------SPASQPEEL--------VARTCSPLHLRSPSPHTLLT 680

  Fly   969 STSSVLRNRLPSPFKKDSALQLNSTNDSLDKSRHRNSLPNVSVNDIFDDLQMKLNLDLGSAIQEN 1033
            :.|..|..|.|...::..:....:...|...|.| .|||..|                    |..
Zfish   681 TLSDPLHQRAPPGMRRSQSADYQNHPSSYTSSCH-GSLPLPS--------------------QPR 724

  Fly  1034 NCCISGRLEIRVIP---KDTSHPDDSVYYDAMGAVKNTPTANEGHDHSDQAVNNCDEMEATSAVI 1095
            .....||.::..||   .:|..|  ||.......::.. ||......|.|..::|..:|......
Zfish   725 AAHSPGRRKLPAIPATAANTKFP--SVIRITRAQLQQL-TAQRPSAMSSQCASDCGSLERRDTDN 786

  Fly  1096 A----FPNKSISKIMSPPGRDATEERTGASLCSLYSAGVNKLKLNGNTAPRTQFKKGSTDGFGEN 1156
            .    .|..:.:.|.||      :|:....|.:|.:..|:.| ||||               |..
Zfish   787 GNNGMHPQDNTADINSP------QEQAAFQLTNLVNVEVDPL-LNGN---------------GHQ 829

  Fly  1157 ESEFDFPLLNPS-------KIPVRQSKCASWAGADFISASKPLESAEVPQEIPYHPQSDTTYSVI 1214
            :.....|.|.||       :.|:..:.|                         :.|.|||..:..
Zfish   830 KPSSPVPSLIPSPRTPPSPRSPILMNGC-------------------------HTPPSDTRRNGN 869

  Fly  1215 DSIPVRK--TTYSIALECPPNISDLTPGLRRRREST---------------------------EG 1250
            :.:.|.|  .:.|:.||   :::|  |.|...:|:.                           |.
Zfish   870 EQLQVLKDLNSDSLTLE---HVND--PTLEEGKENAPATNGHSSPASTPKQDPSRRHSRIPVFEP 929

  Fly  1251 KYVTDPT--------------QLPLKFQRPRSRTSSRTR--------GIPNAMLENSDDNGTVMS 1293
            ..:.||.              ..||......|.:|.|..        .|.:|..|.|.|:.::|.
Zfish   930 SSILDPPHGSAKEKLLQRRVHHFPLSPSASPSLSSDRRAIMIAMQRDQISSASSERSQDDESLMG 994

  Fly  1294 AEKTGHGH------------VVKTEGVKNFTTSENSSEVNPKCTISPPPGDPKIENS--ARLRRY 1344
            :....||.            :.|::..:..|.:.:...:..:....||||.|...::  .|||||
Zfish   995 SRSDRHGDDALSLSSSSSPLLRKSKIPRPVTPTSSMETLTGQFMPRPPPGKPPSRSNVDGRLRRY 1059

  Fly  1345 R 1345
            |
Zfish  1060 R 1060

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Asator	NP_651924.2	STKc_TTBK	172..433	CDD:270919	197/260 (76%)
ttbk2a	XP_002665285.3	Protein Kinases, catalytic domain	20..281	CDD:473864	197/260 (76%)
		PRK07764	<614..>742	CDD:236090	34/191 (18%)