DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Asator and ttbk1b

DIOPT Version :9

Sequence 1:	NP_651924.2	Gene:	Asator / 43794	FlyBaseID:	FBgn0039908	Length:	1349	Species:	Drosophila melanogaster
Sequence 2:	XP_017207296.1	Gene:	ttbk1b / 100000353	ZFINID:	ZDB-GENE-100609-5	Length:	1219	Species:	Danio rerio

Alignment Length:	1297	Identity:	378/1297 - (29%)
Similarity:	516/1297 - (39%)	Gaps:	481/1297 - (37%)

- Green bases have known domain annotations that are detailed below.

  Fly   149 VKAKESVKMTSE--DLLQPGHVVKERWKVVRKIGGGGFGEIYEGQDLITREQVALKVESARQPKQ 211
            |...|::....|  |:|....:||:||||::||||||||||||..||:|||.||||||||:||||
Zfish     8 VHGDENMNGAGEQVDILPSNCLVKDRWKVLKKIGGGGFGEIYEAYDLLTRENVALKVESAQQPKQ 72

  Fly   212 VLKMEVAVLKKLQGKEHVCRFIGCGRNDRFNYVVMQLQGKNLAELRRAQPRGAFSLSTTLRLGLQ 276
            |||||||||||||||.|||:||||||||:||||||||||:|||:|||:||||.||:|||||||.|
Zfish    73 VLKMEVAVLKKLQGKNHVCKFIGCGRNDKFNYVVMQLQGRNLADLRRSQPRGTFSMSTTLRLGKQ 137

  Fly   277 ILKAIESIHSVGFLHRDIKPSNFSVGRLPYNCRRVYMLDFGLARQYTTGTGEVRCPRAAAGFRGT 341
            ||::||:||||||||||||||||::||||..||:.||||||||||||...||||.||:.||||||
Zfish   138 ILESIEAIHSVGFLHRDIKPSNFAMGRLPSTCRKCYMLDFGLARQYTNTNGEVRPPRSVAGFRGT 202

  Fly   342 VRYASINAHRNREMGRHDDLWSLFYMLVEFVNGQLPWRKIKDKEQVGLTKEKYDHRILLKHLPSD 406
            |||||||||:|:||||||||||||||||||..|||||||||||||||..||:|:||:||||:|::
Zfish   203 VRYASINAHKNKEMGRHDDLWSLFYMLVEFTVGQLPWRKIKDKEQVGQIKERYEHRMLLKHMPAE 267

  Fly   407 LKQFLEHIQSLTYGDRPDYAMLIGLFERCMKRRGVKESDPYDWEKVDSTAIGNISATGNPSIPIK 471
            ...|.:|:..|.|..:|||.:|:.:||..||.|.:.|::||||||
Zfish   268 FHIFYDHVLDLDYFTKPDYQLLMSVFENSMKDRVITENEPYDWEK-------------------- 312

  Fly   472 SDYMHGNITQMTVAASNASGTEYIRKRAEIETAHITATDPLNIKEKVDKNCNATSLAQPAKGSGE 536
                              |||:     ..:.|:  |.|.|
Zfish   313 ------------------SGTD-----TALPTS--THTPP------------------------- 327

  Fly   537 PMVQHGNAANNQNITSKGLQQQSTLTNSQVAIANIQSAPSMIEREDV------QYTKLEEGAPTK 595
                               ||.:..|.:.|.:.|:...|..:.||:.      ::...:|.||..
Zfish   328 -------------------QQNTRQTAAIVGVVNVTPVPGELPRENTDDVLQDEHLSDQENAPPA 373

  Fly   596 FITMKPN--------GEC-DNVDIAAKCIFEQKHVEANDDIVGRASLSGVEQHYKSQIKKHNSPE 651
            .|..:|:        ||. |..|      |.:..:        |.|:|      |:|:...:..|
Zfish   374 LIPSRPSEPAPAAPAGEAWDETD------FNRNQL--------RISIS------KTQVAAEDGDE 418

  Fly   652 IANKQIQRTGTVTNDKTSEVNRSTEEQKSTFGRLRVLTAPPMSVHDLPSGGGHSHQVSDLSGKQD 716
                                                           |:|||.|  ||...|
Zfish   419 -----------------------------------------------PAGGGRS--VSPARG--- 431

  Fly   717 PYAATSNAAPIGINSSSTKFGSQHGQIFGLAAMPPINRRSATSTNLRPSSSASQRINSGSTIG-G 780
                                |....|     |.||..|        |.:|..|:|::.....| |
Zfish   432 --------------------GEGDAQ-----ARPPRYR--------RVNSPESERLSGAEDRGDG 463

  Fly   781 A--------VGNGSNTARSS----------------VAGDHSVTQFALIDDENVSALQQVTKGGA 821
            |        :|:.|....||                ..|.|.|:.....:..:.:.::.|
Zfish   464 ADKRSRLDMLGSPSRHVYSSQPAQMLSLEGGQGERLAGGRHDVSADGDQEAHSNAFIRSV----- 523

  Fly   822 LTLASQWKSQFDDSEDTTDNEWNREHQLQPNLEQLIKLDISLPLNEAKPFPQHGVAGTGKLINPP 886
             .||        :.||....||             :.:|....|.:..|..:...:||..  ..|
Zfish   524 -PLA--------EEEDFDSREW-------------VMIDKETELKDFLPGAEPTTSGTTD--EEP 564

  Fly   887 GEAKGRPKRYTLNITGIENYEALRISIPNCWSEPAMGNVLRKGLEPPAVQQAAFDDTVYRMDIAR 951
            .|.  ||         :|::|..|..: :..:|..:....::|:...|.::.|...
Zfish   565 EEL--RP---------LEDHEERRRRV-HGGAEAVVRPKTQRGMMIVAEEEGAGPS--------- 608

  Fly   952 NVCVRETYSEITHLARPSTSSVLRNRLPSPFKKDSA-LQLNSTNDSLDKSRHRNSLPNVSVNDIF 1015
                 ..:|....|.|    |..|.|...||..|.. :.:...:.|..::|.:. :..||...:|
Zfish   609 -----PGHSSCHTLPR----SCPRRRESEPFGPDGPDIAVAEPSPSFSQTRMKR-VDFVSGVLMF 663

  Fly  1016 DDLQMKLNLDLGSAIQENNCCISGRLEIRVIPKDTSHPDDSVYYDAMGAVKNTPTANEGHDHSDQ 1080
            |||:.:                       |:....|..|.|            |.::||.
Zfish   664 DDLREE-----------------------VVKTGGSGSDGS------------PRSSEGS----- 688

  Fly  1081 AVNNCDEMEATSAVIAFPNKSISKIMSPPGRDATEERTGASLCSLYSAGVNKLKLNGNTAPRTQF 1145
                             |..:.|.:::|..||..:|. |:....|.|||      ||..:|
Zfish   689 -----------------PEGAASTLLAPAHRDHDQEE-GSRTLVLVSAG------NGQVSP---- 725

  Fly  1146 KKGSTDGFGENESEFDFPLLNPSKIPVRQSKCASWAGADFISASKPLESAEVPQEIPYHPQSDTT 1210
                .||.|.                              ::|..|.....||:|    .:..|.
Zfish   726 ----GDGQGT------------------------------LAALTPQGERPVPEE----SEPGTL 752

  Fly  1211 YSVIDS--IPVRKTTYSI---ALECPP-------------------------------------- 1232
            .|||.|  .|:..||.::   ....||
Zfish   753 SSVIKSEPRPIVMTTAAVITSGSSSPPFTKVERTFIHIAETSHLNVMTARHRPSGFDEPISVERE 817

  Fly  1233 --------------NISDLTPGLRRRRESTEGKYVTDPTQLPLKFQRPRSRTSSRTRGIPNAMLE 1283
                          .|...:.|::..||..|.|             :..|......:.:.|.::.
Zfish   818 EMGEEKEDRAGQLVEIERNSEGIKVEREGDEKK-------------KEESEAEKEKQEVENVIIS 869

  Fly  1284 NSDDNGTVMSAE-------KTGHGHVVKTEGVKNFTTSENSSEVNPKCTISPPPG-DPKIEN 1337
            :.::..||..||       |.......|.:..::..|:|...|.....::||... |.::|:
Zfish   870 SREEAETVFLAEQPVSIAIKENISIETKLDDEQDGVTTEKEQEQEESPSVSPEQNRDAEVED 931

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Asator	NP_651924.2	STKc_TTBK	172..433	CDD:270919	200/260 (77%)
Asator	NP_651924.2	S_TKc	173..414	CDD:214567	192/240 (80%)
ttbk1b	XP_017207296.1	STKc_TTBK1	33..294	CDD:271032	200/260 (77%)
ttbk1b	XP_017207296.1	SPS1	34..393	CDD:223589	233/447 (52%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	410	1.000	Domainoid score	I658
eggNOG	1	0.900	-	-		E1_KOG1164
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0002285
OrthoInspector	1	1.000	-	-		otm25618
orthoMCL	1	0.900	-	-		OOG6_101431
Panther	1	1.100	-	-	O	PTHR11909
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R3595
SonicParanoid	1	1.000	-	-		X1513
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	10	9.840