DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment bip2 and Ing2

DIOPT Version :9

Sequence 1:	NP_651923.2	Gene:	bip2 / 43793	FlyBaseID:	FBgn0026262	Length:	1406	Species:	Drosophila melanogaster
Sequence 2:	NP_075992.2	Gene:	Ing2 / 69260	MGIID:	1916510	Length:	281	Species:	Mus musculus

Alignment Length:	234	Identity:	57/234 - (24%)
Similarity:	97/234 - (41%)	Gaps:	42/234 - (17%)

- Green bases have known domain annotations that are detailed below.

  Fly  1190 KKRERDNSPELARFSPLVTGPPKNKQSETLHLGNSS----TAVLPVPSPVAVRAVQLPV-SQTSS 1249
            |.::.|:|.:..|....:.....|.|    .||:..    |.:|.:   |..||.|:.: ||.
Mouse    70 KYKKEDDSNQKKRLQQHLQRALINSQ----ELGDEKIQIVTQMLEL---VENRARQMELHSQC-- 125

  Fly  1250 NSAGWLSNPNNSNTAS--STLSASSVLLPQQLMLAPHTIMNNFVPAMCNSTGTVSKSGLCSSPPN 1312
                 ..:|..|..||  |.:.:|.   |::....|.....:....:|:.|..:..   |...|.
Mouse   126 -----FQDPAESERASDKSKMDSSQ---PERSSRRPRRQRTSESRDLCHMTNGIDD---CDDQPP 179

  Fly  1313 TSEENANAMQ----IAESSRPSSYVD--AEGNRIWICPACGKVDDGSAMIGCDG--CD-AWYHWI 1368
            ..:.:.:|.:    .|:..|.:|.|:  .:.|....| .|.:|..|. |||||.  |. .|:|:.
Mouse   180 KEKRSKSAKKKKRSKAKQEREASPVEFAIDPNEPTYC-LCNQVSYGE-MIGCDNEQCPIEWFHFS 242

  Fly  1369 CVGITFAPKDNDDWFCRVC--VTKKRIHGSEKKKRRNKK 1405
            ||.:|:.||..  |:|..|  ..:|.:..|.:|.::.::
Mouse   243 CVSLTYKPKGK--WYCPKCRGDNEKTMDKSTEKTKKERR 279

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
bip2	NP_651923.2	BTP	4..80	CDD:128846
bip2	NP_651923.2	PHD_TAF3	1342..1387	CDD:276997	19/47 (40%)
Ing2	NP_075992.2	ING	28..122	CDD:289749	14/58 (24%)
		TNG2	31..260	CDD:227367	53/213 (25%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	123..204		18/93 (19%)
		PHD_ING2	214..262	CDD:277153	20/51 (39%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	261..281		3/19 (16%)
		PBR. /evidence=ECO:0000250\|UniProtKB:Q9H160	265..281		3/15 (20%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5034
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.900