DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment bip2 and ing1

DIOPT Version :9

Sequence 1:	NP_651923.2	Gene:	bip2 / 43793	FlyBaseID:	FBgn0026262	Length:	1406	Species:	Drosophila melanogaster
Sequence 2:	NP_001035446.1	Gene:	ing1 / 678608	ZFINID:	ZDB-GENE-060421-4388	Length:	309	Species:	Danio rerio

Alignment Length:	386	Identity:	72/386 - (18%)
Similarity:	121/386 - (31%)	Gaps:	148/386 - (38%)

- Green bases have known domain annotations that are detailed below.

  Fly  1046 KHHKKLKKVKEGKNKKKKEKKDKSK------------KADQIGLPSFKSDRKIKANDKRQKKEKK 1098
            |:.:.|.::.|...|.::|.....:            :.:::|      |.||:.  ..|..|..
Zfish    45 KYQEILNELDEAYEKHRQESDPVQRRRLLHCIQRSLIRTEELG------DEKIQI--AGQMVEMV 101

  Fly  1099 KDKDKQILVHIPDDTEEFDKVPLANNDEPVLKSSSMTINPSLGAATSGISPNQIPKLTLKLSGKS 1163
            :::.:|:..|    .|.|.    |::|.|   .||:    |:|:..|.|:...:..::..|...|
Zfish   102 ENRSRQLEWH----GELFQ----ASHDSP---ESSV----SVGSTPSAITTTAMTTISDILLSAS 151

  Fly  1164 TLFSSSEKEMT------DAGKLKQTTILSSENKKRERDNSPELARFSPLVTGPPKNKQSETLHLG 1222
            .|.::..:|.|      ..||..:.....|||  ||..|. .|.....:.:|.||.|:
Zfish   152 KLTANRRREETPSSVDKSGGKRSRRQKNGSEN--RENSNY-SLEHIEDVSSGTPKEKK------- 206

  Fly  1223 NSSTAVLPVPSPVAVRAVQLPVSQTSSNSAGWLSNPNNSNTASSTLSASSVLLPQQLMLAPHTIM 1287
                                |.:..:|:.....|........|          |..|.:.|:.
Zfish   207 --------------------PKASATSSKKKKRSKSKQDREPS----------PTDLPIDPNE-- 239

  Fly  1288 NNFVPAMCNSTGTVSKSGLCSSPPNTSEENANAMQIAESSRPSSYVDAEGNRIWICPACGKVDDG 1352
                |..|                                                 .|.:|..|
Zfish   240 ----PTYC-------------------------------------------------LCEQVSYG 251

  Fly  1353 SAMIGCDGCDA---WYHWICVGITFAPKDNDDWFCRVC------VTKKRIHGSEKKKRRNK 1404
            . |||||..:.   |:|:.||.:...||..  |:|..|      ...|.:..|:|::..|:
Zfish   252 E-MIGCDNDECTIEWFHFSCVDLHHKPKGK--WYCPKCRGDNEKTMDKALERSKKERAYNR 309

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
bip2	NP_651923.2	BTP	4..80	CDD:128846
bip2	NP_651923.2	PHD_TAF3	1342..1387	CDD:276997	16/47 (34%)
ing1	NP_001035446.1	ING	17..111	CDD:289749	12/73 (16%)
		TNG2	18..287	CDD:227367	67/362 (19%)
		PHD_ING1_2	242..286	CDD:277059	17/95 (18%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5034
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	1	0.900