DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment bip2 and ING3

DIOPT Version :9

Sequence 1:	NP_651923.2	Gene:	bip2 / 43793	FlyBaseID:	FBgn0026262	Length:	1406	Species:	Drosophila melanogaster
Sequence 2:	NP_061944.2	Gene:	ING3 / 54556	HGNCID:	14587	Length:	418	Species:	Homo sapiens

Alignment Length:	398	Identity:	85/398 - (21%)
Similarity:	148/398 - (37%)	Gaps:	118/398 - (29%)

- Green bases have known domain annotations that are detailed below.

  Fly  1049 KKLKKVKEGKNKKKKEKKDKSKKADQIGLPSFKSDRKIKANDKRQ-------------KKEK--- 1097
            :.|:|:.:...|.|.|     .:||..|:......|.::.:...|             :|.|
Human    92 RHLRKLDQELAKFKME-----LEADNAGITEILERRSLELDTPSQPVNNHHAHSHTPVEKRKYNP 151

  Fly  1098 ------------KKDKDKQILVHIPDDTEEFDKVPLANNDEPVLKSSSMTINPS-------LGAA 1143
                        ||.|.:.:|..:..|..:.:.:...||:.....:::..:|.|       :|:.
Human   152 TSHHTTTDHIPEKKFKSEALLSTLTSDASKENTLGCRNNNSTASSNNAYNVNSSQPLGSYNIGSL 216

  Fly  1144 TSGISPNQIPKLTLKLSGKSTLFSSSEKEMTDAGKLKQTTILSSENKKRE--RDNSPELARFSPL 1206
            :||             :|...:..::.:.:....::|:....||.....|  ::|..:|
Human   217 SSG-------------TGAGAITMAAAQAVQATAQMKEGRRTSSLKASYEAFKNNDFQL------ 262

  Fly  1207 VTGPPKNKQSETLHLGNSSTAVLPVPSPVAVRAVQLPVSQTSSNSA-----GWLSNPNNSNTASS 1266
              |...:...||:...:||             |:...::|.:|:||     |..|  .|:|.:||
Human   263 --GKEFSMARETVGYSSSS-------------ALMTTLTQNASSSAADSRSGRKS--KNNNKSSS 310

  Fly  1267 TLSASSVLLPQQLMLAPHTIMNNFVPAMCNSTGTVSKSGLCSSPPNTSEENANAMQIAESSRPSS 1331
            ..|:||                       :|:.::|.   |||.....:|.:....:...|..:|
Human   311 QQSSSS-----------------------SSSSSLSS---CSSSSTVVQEISQQTTVVPESDSNS 349

  Fly  1332 YVD--AEGNRIWICPACGKVDDGSAMIGCDGCDA---WYHWICVGITFAPKDNDDWFCRVCVTKK 1391
            .||  .:.|....| .|.:|..|. |:|||..|.   |:|:.|||:|.|||..  |:|..|....
Human   350 QVDWTYDPNEPRYC-ICNQVSYGE-MVGCDNQDCPIEWFHYGCVGLTEAPKGK--WYCPQCTAAM 410

  Fly  1392 RIHGSEKK 1399
            :..||..|
Human   411 KRRGSRHK 418

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
bip2	NP_651923.2	BTP	4..80	CDD:128846
bip2	NP_651923.2	PHD_TAF3	1342..1387	CDD:276997	20/47 (43%)
ING3	NP_061944.2	ING	3..102	CDD:404028	2/9 (22%)
		TNG2	4..410	CDD:227367	82/388 (21%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	127..165		3/37 (8%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	286..325		15/66 (23%)
		PHD_ING3	362..406	CDD:277060	20/47 (43%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5034
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.900