DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment bip2 and ING2

DIOPT Version :9

Sequence 1:	NP_651923.2	Gene:	bip2 / 43793	FlyBaseID:	FBgn0026262	Length:	1406	Species:	Drosophila melanogaster
Sequence 2:	NP_001555.1	Gene:	ING2 / 3622	HGNCID:	6063	Length:	280	Species:	Homo sapiens

Alignment Length:	232	Identity:	55/232 - (23%)
Similarity:	95/232 - (40%)	Gaps:	38/232 - (16%)

- Green bases have known domain annotations that are detailed below.

  Fly  1190 KKRERDNSPELARFSPLVTGPPKNKQSETLHLGNSS----TAVLPVPSPVAVRAVQLPV-SQTSS 1249
            |.::.|:..:..|...|:.....|.|    .||:..    |.:|.:   |..||.|:.: ||.
Human    69 KYKKEDDLNQKKRLQQLLQRALINSQ----ELGDEKIQIVTQMLEL---VENRARQMELHSQC-- 124

  Fly  1250 NSAGWLSNPNNSNTASSTLSASSVLLPQQLMLAPHTIMNNFVPAMCNSTGTVSKSGLCSSPPNTS 1314
                 ..:|..|..||......| ..|::....|.....:....:|:....:..   |...|...
Human   125 -----FQDPAESERASDKAKMDS-SQPERSSRRPRRQRTSESRDLCHMANGIED---CDDQPPKE 180

  Fly  1315 EENANAMQ----IAESSRPSSYVD--AEGNRIWICPACGKVDDGSAMIGCDG--CD-AWYHWICV 1370
            :::.:|.:    .|:..|.:|.|:  .:.|....| .|.:|..|. |||||.  |. .|:|:.||
Human   181 KKSKSAKKKKRSKAKQEREASPVEFAIDPNEPTYC-LCNQVSYGE-MIGCDNEQCPIEWFHFSCV 243

  Fly  1371 GITFAPKDNDDWFCRVC--VTKKRIHGSEKKKRRNKK 1405
            .:|:.||..  |:|..|  ..:|.:..|.:|.:::::
Human   244 SLTYKPKGK--WYCPKCRGDNEKTMDKSTEKTKKDRR 278

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
bip2	NP_651923.2	BTP	4..80	CDD:128846
bip2	NP_651923.2	PHD_TAF3	1342..1387	CDD:276997	19/47 (40%)
ING2	NP_001555.1	ING_ING2	32..119	CDD:341094	14/56 (25%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	122..204		16/92 (17%)
		PHD_ING2	213..261	CDD:277153	20/51 (39%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	258..280		4/21 (19%)
		PBR. /evidence=ECO:0000269\|PubMed:16728974	264..280		3/15 (20%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5034
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.900