DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment bip2 and Ing1

DIOPT Version :9

Sequence 1:	NP_651923.2	Gene:	bip2 / 43793	FlyBaseID:	FBgn0026262	Length:	1406	Species:	Drosophila melanogaster
Sequence 2:	NP_036049.2	Gene:	Ing1 / 26356	MGIID:	1349481	Length:	279	Species:	Mus musculus

Alignment Length:	448	Identity:	79/448 - (17%)
Similarity:	139/448 - (31%)	Gaps:	190/448 - (42%)

- Green bases have known domain annotations that are detailed below.

  Fly   976 SLAGGADLIPLSRVSDSEYSSKIVPFSSLGGTIPNQIKISEEHNIFSTFSNYEDITITPTGLTSL 1040
            |.|.|..:..::.|.|...|.:.:||.     :...:.:..|.:     :.|::|      |..|
Mouse     3 SPANGEQIHLVNYVEDYLDSIESLPFD-----LQRNVSLMREID-----AKYQEI------LKEL 51

  Fly  1041 EPKMRKHHKKLKKVKEGKNKKKKEK--KDKSKKADQIGLPSFKSDRKIKANDKRQKKEKKKDKDK 1103
            :    .:::|.|:..:|..|::...  :....::.::|      |.||:.  ..|..|..:::.:
Mouse    52 D----DYYEKFKRETDGTQKRRVLHCIQRALIRSQELG------DEKIQI--VSQMVELVENRSR 104

  Fly  1104 QILVHIPDDTEEFDKVPLANNDEPVLKSSSMTINPSLGAATSGISPNQIPKLTLKLSGKSTLFSS 1168
            |:..|:    |.|:    |:.|              :...|.|             |||:....|
Mouse   105 QVDSHV----ELFE----AHQD--------------ISDGTGG-------------SGKAGQDKS 134

  Fly  1169 SEKEMTDAGKLKQTTILSSENKKR--------ERDNSPELARFSPLVTGPPKNKQSETLHLGNSS 1225
            ..:.:|.|.|         .|.||        .|:|:........:.:|.||.|:::|
Mouse   135 KSEAITQADK---------PNNKRSRRQRNNENRENASNNHDHDDITSGTPKEKKAKT------- 183

  Fly  1226 TAVLPVPSPVAVRAVQLPVSQTSSNSAGWLSNPNNSNTASSTLSASSVLLPQQLMLAPHTIMNNF 1290
                                          |.....:.|.:...||    |..|.:.|:.
Mouse   184 ------------------------------SKKKKRSKAKAEREAS----PADLPIDPNE----- 209

  Fly  1291 VPAMCNSTGTVSKSGLCSSPPNTSEENANAMQIAESSRPSSYVDAEGNRIWICPACGKVDDGSAM 1355
             |..|                                                 .|.:|..|. |
Mouse   210 -PTYC-------------------------------------------------LCNQVSYGE-M 223

  Fly  1356 IGCDGCDA---WYHWICVGITFAPKDNDDWFCRVC------VTKKRIHGSEKKKRRNK 1404
            ||||..:.   |:|:.|||:...||..  |:|..|      ...|.:..|:|::..|:
Mouse   224 IGCDNDECPIEWFHFSCVGLNHKPKGK--WYCPKCRGESEKTMDKALEKSKKERAYNR 279

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
bip2	NP_651923.2	BTP	4..80	CDD:128846
bip2	NP_651923.2	PHD_TAF3	1342..1387	CDD:276997	17/47 (36%)
Ing1	NP_036049.2	ING	15..111	CDD:315637	22/127 (17%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	115..206		27/167 (16%)
		PHD_ING1_2	212..256	CDD:277059	18/95 (19%)
		PBR. /evidence=ECO:0000250\|UniProtKB:Q9H160	262..279		3/16 (19%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5034
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.900