DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment bip2 and Taf3

DIOPT Version :9

Sequence 1:	NP_651923.2	Gene:	bip2 / 43793	FlyBaseID:	FBgn0026262	Length:	1406	Species:	Drosophila melanogaster
Sequence 2:	NP_082024.2	Gene:	Taf3 / 209361	MGIID:	2388097	Length:	932	Species:	Mus musculus

Alignment Length:	1442	Identity:	320/1442 - (22%)
Similarity:	471/1442 - (32%)	Gaps:	552/1442 - (38%)

- Green bases have known domain annotations that are detailed below.

  Fly     2 MADRYASDLALVVVAQITQTIGYSCTLSAPLELLQDILQKFVQEFARDMHRHMEHANRIEPNLKD 66
            |.:.|:..|..|.||||.|.:|:.....:...||.|:||:::|:..|..||:.|...|.:|.|.|
Mouse     1 MCESYSRSLLRVSVAQICQALGWDSVQLSACHLLTDVLQRYLQQLGRGCHRYSELYGRTDPILDD 65

  Fly    67 ARLSIKNLSINVQELLDYIGNVEPVGFIRDVPQFPIGKSVNMNFLKPGSAETLTRPVYIFEYLPP 131
            ...:.:.:.:|:.||.|||.|:|||.|...:|.||:.|:..:.|.:|||.:...|..||.:||||
Mouse    66 VGEAFQLMGVNLHELEDYIHNIEPVTFPHQIPSFPVSKNNVLQFPQPGSKDAEERKDYIPDYLPP 130

  Fly   132 MQDPELREIPADVQKEFSEKQEFCSKAEYSSTNAADKLGAKHIDSISPNTVINFRSNAFELDVGS 196
            :         ...|:|..|:|
Mouse   131 I---------VSSQEEEEEEQ-------------------------------------------- 142

  Fly   197 SVREMSSVVMTTGGFISPAIEGKLPED-------IIPDIVEKFLG---LDAPFSPTIIVNSLQKS 251
                    |.|.||..:.|::..|.||       :|.|  |.|||   ||:|        .:::.
Mouse   143 --------VPTDGGTSAEAMQVPLEEDDEMEEEEVIND--ENFLGKRPLDSP--------EVEEM 189

  Fly   252 PQLALSDRDKTVNPRKIIPSETKIFKQNAALLTSGHSESSIIYASNNHTMLTVTTPKKNRKQKHD 316
            |.:.        .||.:   .||....:..||.:....|||    |......|.:|.  |.|...
Mouse   190 PSMK--------RPRLL---STKGDSLDVVLLEAREPLSSI----NPQKTPPVLSPV--RVQDRA 237

  Fly   317 LICEPGQSELLTNPFEKAQEKSQRKALKMYKQTSKNQRDSSINQIQNMKKLKKKFNRGSFDPNKK 381
            .:..|.....:..||.|                         :|:...|.|:.|    ||.|..|
Mouse   238 DLAPPSPQPPMLAPFAK-------------------------SQLPIAKPLETK----SFTPKTK 273

  Fly   382 HLEKIFKKQSKLKQNDLQLDIDEKHFLQNSQTTSGLAIKANSNENALQADIPSQPPTVTSQIENN 446
                  .|.|...|                        |..|.:.||      .|..:.|.|.:
Mouse   274 ------TKASSPGQ------------------------KTKSPKAAL------SPARLGSPIRS- 301

  Fly   447 FRNSIYPVQPSVIQQTQVLLAEKKSGSEPERSKLDIFKKISKPRTPR-PDIGATLVPPGTGVSVF 510
                     |..|.:      ||||   |.|||        .|::|: |.|.|.:  |.|.|...
Mouse   302 ---------PKTIPK------EKKS---PGRSK--------SPKSPKSPKIVAHV--PQTPVRPE 338

  Fly   511 GSTMTPSALISLPSGTTITPTPSLGLNSENKNVPSMKINPCNIFDGTIP-LTKAGVEMSIIDSPK 574
            ....||||::   ...|:..|           :|.||  |..    |.| :.|..:||      :
Mouse   339 TPNRTPSAMV---VEKTVKET-----------IPVMK--PTQ----TPPEVVKLNIEM------Q 377

  Fly   575 PKKRGRKPGGKNVIKQTNVVSQPLINKVERKKSSQAITLPLSSSPMIITQSSLNVSPPTEPLNLC 639
            |||              .||:...|:               .|...:|.::.....|  :|....
Mouse   378 PKK--------------PVVTDKTID---------------DSIDAVIARACAEREP--DPFEFS 411

  Fly   640 N-TEQPSNNFLSNLYAKEKKDRKKYKSLPENVMQLDKSCSPEKASTLHNSI-----RPTKQNNDV 698
            : :|...:.|.|                |:.:.  ...|:..||||..|:.     .|...::..
Mouse   412 SGSESEGDTFTS----------------PKRIS--GSECATPKASTSSNNFTKSLATPLPLSSGT 458

  Fly   699 QCSDKFVT----ISNALSNASIYPGIQTGMVPLLPLLQFPPRPGLIPTGPGLFPAVTGLVGFGNH 759
            ..||...|    |...:..|.:  |..:.|.|..|.:.
Mouse   459 SSSDNSWTMDASIDEVVRKAKL--GAPSNMPPTFPYIS--------------------------- 494

  Fly   760 GNRIPISPFIDYPGPE------ESVADTVRCPPIKDSPVTDSDQFLSRSSTQTDLQMDRNYCNVA 818
                  ||.|..|.||      |..|.......:|.....:....|.:...|.|.:.:|......
Mouse   495 ------SPSISPPTPEPLHKGYEEKAKLPSSVDVKKKLKKELKTKLKKKEKQRDRERERERNKER 553

  Fly   819 PLVPDSMKFAECKSVSCASTILENPSAQATSKINTKPLLEASGNPD-DP----IEVSDDSDESMH 878
            ....|.|:              |....:...|....|..|...:.| ||    |:..:|.|.:..
Mouse   554 SKEKDKMR--------------EREKEKEAGKELKYPWRELMKDEDSDPYKFKIKEFEDIDAAKV 604

  Fly   879 NRQ--MVQRKTPISSPTYVKTSFAELNPSSFTSAASNGEEKSKMDLRNIVSLSSNEPLKKFKKLV 941
            ..:  :|:|:             .|.:.........:..||.|.:         .|.||:..:..
Mouse   605 RLKDGIVRRE-------------REKHKDKKKDRERSKREKDKRE---------RERLKEKNRED 647

  Fly   942 KQSFPDVKSVPHTPASHSSFPQFNLPNFMGGDKFSLAGGADLIPLSRVSDSEYSSKIVPFSSLGG 1006
            |...|..:.|  .|....:.|.|:
Mouse   648 KIKAPPTQLV--LPPKEMALPLFS----------------------------------------- 669

  Fly  1007 TIPNQIKISEEHNIFSTFSNYEDITITPTGLTSLEPKMRKHHKKLKKVKEGKNKKKKEKKDKSKK 1071
              |:.:::......||        .:.|..|  .|.|.:...|:.||.|:.|.|||:::|:|.||
Mouse   670 --PSAVRVPAMLPAFS--------PMLPEKL--FEEKEKPKEKERKKDKKEKKKKKEKEKEKEKK 722

  Fly  1072 ADQIGLPSFKSDRKIKANDKRQKKEKKKDKDKQILVHIPDDTEEFDKVPLANNDEPVLKSSSMTI 1136
                     :.:|: |...:|:|:||:|:|.|.            :|:.:    |||:.:.|..
Mouse   723 ---------ERERE-KERREREKREKEKEKHKH------------EKIKV----EPVIPAPSPV- 760

  Fly  1137 NPSLGAATSGISPNQIPKLTLKLSGKSTLFSSSEKEMTDAGKLKQTTILSSENKKRERDNSPELA 1201
                           ||:|||::.               ||:.|  .::|......|...:|.|.
Mouse   761 ---------------IPRLTLRVG---------------AGQDK--IVISKVVPAPEAKPAPSLN 793

  Fly  1202 RFSPLVTGPPKNKQSETLHLGNSSTAVLPVPSPVAVRAVQLPVSQTSSNSAGWLSNPNNSNTASS 1266
            |        ||...              |.|.|:.||....|           |..|
Mouse   794 R--------PKTPP--------------PAPVPIPVRVSPTP-----------LQPP-------- 817

  Fly  1267 TLSASSVLLPQQLMLAPHTIMNNFVPAMCNSTGTVSKSGLCSSPPNTSEENANAMQIAESSRPSS 1331
             |...:.:.| .||.:|       .||:       |..|...:|          ::...:...|:
Mouse   818 -LLTQAAVCP-ALMPSP-------APAL-------SGIGSAKAP----------VRSVVTETVST 856

  Fly  1332 YV--DAEGNRIWICPACGKVDDGSAMIGCDGCDAWYHWICVGITFAPKDNDDWFCRVCVTKKRIH 1394
            ||  |..||:|||||.|.|.||||.|||||.||.||||.||||..||.:...|||..|..|
Mouse   857 YVIRDEWGNQIWICPGCNKPDDGSPMIGCDDCDDWYHWPCVGIMAAPPEEMQWFCPKCANK---- 917

  Fly  1395 GSEKKKRRNKKK 1406
              .||.:::||:
Mouse   918 --IKKDKKHKKR 927

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
bip2	NP_651923.2	BTP	4..80	CDD:128846	24/75 (32%)
bip2	NP_651923.2	PHD_TAF3	1342..1387	CDD:276997	29/44 (66%)
Taf3	NP_082024.2	BTP	5..79	CDD:128846	24/73 (33%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	130..201		25/152 (16%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	213..347		51/233 (22%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	403..465		15/81 (19%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	480..579		22/147 (15%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	607..657		11/71 (15%)
		RSB_motif	607..>656	CDD:292910	11/70 (16%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	681..746		27/96 (28%)
		PHD_TAF3	869..914	CDD:276997	29/44 (66%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167837879
Domainoid	1	1.000	77	1.000	Domainoid score	I8873
eggNOG	1	0.900	-	-		E1_COG5034
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	216	1.000	Inparanoid score	I3596
Isobase	1	0.950	-	0	Normalized mean entropy	S5668
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0006535
OrthoInspector	1	1.000	-	-		oto93501
orthoMCL	1	0.900	-	-		OOG6_108171
Panther	1	1.100	-	-	LDO	PTHR46452
Phylome	0	0.000	Not matched by this tool.
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R1475
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
	11	10.820