DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CaMKI and Stk17b

DIOPT Version :9

Sequence 1:	NP_524622.1	Gene:	CaMKI / 43792	FlyBaseID:	FBgn0016126	Length:	405	Species:	Drosophila melanogaster
Sequence 2:	NP_598571.2	Gene:	Stk17b / 98267	MGIID:	2138162	Length:	372	Species:	Mus musculus

Alignment Length:	291	Identity:	101/291 - (34%)
Similarity:	157/291 - (53%)	Gaps:	33/291 - (11%)

- Green bases have known domain annotations that are detailed below.

  Fly    25 VSIEEKYNLHGL----LGTGAFSEVRLAESKDSPGEHFAVKIIDKKALKGKEESLE--NEIRVLR 83
            :..|...|.:.|    ||.|.|:.||...|| |.|:.:|.|.: ||..:|::...|  :||.||
Mouse    23 IKTENFNNFYTLTPKELGRGKFAVVRQCISK-STGQEYAAKSL-KKRRRGQDCRAEILHEIAVL- 84

  Fly    84 RFSANHFDGKCLNGTRLTHPNIVQLLETYEDKSKVYLVMELVTGGELFD----RIVEKGSYTEKD 144
                 .....|        |:::.|.|.||:.:::.||:|...|||:|:    .:.|..|  |.|
Mouse    85 -----ELARSC--------PHVINLHEVYENATEIILVLEYAAGGEIFNLCLPELAEMVS--END 134

  Fly   145 ASHLIRQILEAVDYMHEQGVVHRDLKPENLLYYS--PDDDSKIMISDFGLS-KMEDSGIMATACG 206
            ...||:||||.|.|:|:..:||.||||:|:|..|  |..|.||:  |||:| |:.::..:....|
Mouse   135 VIRLIKQILEGVHYLHQNNIVHLDLKPQNILLSSIYPLGDIKIV--DFGMSRKIGNASELREIMG 197

  Fly   207 TPGYVAPEVLAQKPYGKAVDVWSIGVISYILLCGYPPFYDENDANLFAQILKGDFEFDSPYWDEI 271
            ||.|:|||:|...|...|.|:|:||:|:|:||....||..|::...:..|.:.:.::....:..:
Mouse   198 TPEYLAPEILNYDPITTATDMWNIGIIAYMLLTHTSPFVGEDNQETYLNISQVNVDYSEEMFSSV 262

  Fly   272 SESAKHFIKNLMCVTVEKRYTCKQALGHAWI 302
            |:.|..||::|:....|||.|.:..|.|:|:
Mouse   263 SQLATDFIQSLLVKNPEKRPTAESCLSHSWL 293

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CaMKI	NP_524622.1	STKc_CaMKI	27..301	CDD:270985	100/286 (35%)
CaMKI	NP_524622.1	S_TKc	31..302	CDD:214567	99/283 (35%)
Stk17b	NP_598571.2	STKc_DRAK2	24..293	CDD:271100	100/288 (35%)
		S_TKc	37..293	CDD:214567	97/275 (35%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	305..348
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG0032
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.810