DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CaMKI and STK17A

DIOPT Version :9

Sequence 1:	NP_524622.1	Gene:	CaMKI / 43792	FlyBaseID:	FBgn0016126	Length:	405	Species:	Drosophila melanogaster
Sequence 2:	NP_004751.2	Gene:	STK17A / 9263	HGNCID:	11395	Length:	414	Species:	Homo sapiens

Alignment Length:	364	Identity:	123/364 - (33%)
Similarity:	184/364 - (50%)	Gaps:	44/364 - (12%)

- Green bases have known domain annotations that are detailed below.

  Fly    37 LGTGAFSEVRLAESKDSPGEHFAVKIIDKKALKGKEESLE--NEIRVLRRFSANHFDGKCLNGTR 99
            ||.|.|:.||....||| |:.||.|.: :|..||::..:|  :||.||.....|
Human    67 LGRGKFAVVRKCIKKDS-GKEFAAKFM-RKRRKGQDCRMEIIHEIAVLELAQDN----------- 118

  Fly   100 LTHPNIVQLLETYEDKSKVYLVMELVTGGELFDRIV--EKGSYTEKDASHLIRQILEAVDYMHEQ 162
               |.::.|.|.||..|::.||:|...|||:||:.|  .:.::.|||...|:|||||.|.::|.:
Human   119 ---PWVINLHEVYETASEMILVLEYAAGGEIFDQCVADREEAFKEKDVQRLMRQILEGVHFLHTR 180

  Fly   163 GVVHRDLKPENLLYYSPDDDSKIMISDFGLSK-MEDSGIMATACGTPGYVAPEVLAQKPYGKAVD 226
            .|||.||||:|:|..|......|.|.|||||: :::|..:....|||.|||||:|:..|...|.|
Human   181 DVVHLDLKPQNILLTSESPLGDIKIVDFGLSRILKNSEELREIMGTPEYVAPEILSYDPISMATD 245

  Fly   227 VWSIGVISYILLCGYPPFYDENDANLFAQILKGDFEFDSPYWDEISESAKHFIKNLMCVTVEKRY 291
            :|||||::|::|.|..||...:....|..|.:.:..:....:|.:||||..||:.|:....|.|.
Human   246 MWSIGVLTYVMLTGISPFLGNDKQETFLNISQMNLSYSEEEFDVLSESAVDFIRTLLVKKPEDRA 310

  Fly   292 TCKQALGHAWISGNEASSRNIHGTVSEQLKKNFAKSRWKQAYYAATVIRQMQRMALNSNSNANFD 356
            |.::.|.|.|:            |.|...:.:|   |.::|...|..:::.     :|....|.|
Human   311 TAEECLKHPWL------------TQSSIQEPSF---RMEKALEEANALQEG-----HSVPEINSD 355

  Fly   357 SSNSSNQDSTTPTAATGAWTSNVLSSQQSVQSHAQEMNK 395
            :..|..::|.. |......||..|.  |..||..::|.:
Human   356 TDKSETKESIV-TEELIVVTSYTLG--QCRQSEKEKMEQ 391

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CaMKI	NP_524622.1	STKc_CaMKI	27..301	CDD:270985	103/268 (38%)
CaMKI	NP_524622.1	S_TKc	31..302	CDD:214567	103/269 (38%)
STK17A	NP_004751.2	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..40
		STKc_DRAK1	51..321	CDD:271099	103/269 (38%)
		S_TKc	64..321	CDD:214567	103/269 (38%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	342..363		4/25 (16%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG0032
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.810