DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CaMKI and DCLK1

DIOPT Version :9

Sequence 1:	NP_524622.1	Gene:	CaMKI / 43792	FlyBaseID:	FBgn0016126	Length:	405	Species:	Drosophila melanogaster
Sequence 2:	NP_001317000.1	Gene:	DCLK1 / 9201	HGNCID:	2700	Length:	740	Species:	Homo sapiens

Alignment Length:	377	Identity:	138/377 - (36%)
Similarity:	212/377 - (56%)	Gaps:	37/377 - (9%)

- Green bases have known domain annotations that are detailed below.

  Fly    16 KDLKELNKQV--SIEEKYNLHGLLGTGAFSEVRLAESKDSPGEHFAVKIIDKKALKGKEESLENE 78
            :::.|...|:  :|.|:|.:...:|.|.|:.|:....: |....:|:|||.|...:|||..::||
Human   373 EEVSEEGFQIPATITERYKVGRTIGDGNFAVVKECVER-STAREYALKIIKKSKCRGKEHMIQNE 436

  Fly    79 IRVLRRFSANHFDGKCLNGTRLTHPNIVQLLETYEDKSKVYLVMELVTGGELFDRIVEKGSYTEK 143
            :.:||               |:.|||||.|:|..:..:::|||||||.||:|||.|.....|||:
Human   437 VSILR---------------RVKHPNIVLLIEEMDVPTELYLVMELVKGGDLFDAITSTNKYTER 486

  Fly   144 DASHLIRQILEAVDYMHEQGVVHRDLKPENLLYYSPDDDSK-IMISDFGLSKMEDSGIMATACGT 207
            |||.::..:..|:.|:|...:||||:||||||.|...|.|| :.:.||||:.:.| |.:.|.|||
Human   487 DASGMLYNLASAIKYLHSLNIVHRDIKPENLLVYEHQDGSKSLKLGDFGLATIVD-GPLYTVCGT 550

  Fly   208 PGYVAPEVLAQKPYGKAVDVWSIGVISYILLCGYPPFYDENDAN--LFAQILKGDFEFDSPYWDE 270
            |.|||||::|:..||..||:|:.|||:||||||:|||....|..  ||.|||.|..:|.|||||.
Human   551 PTYVAPEIIAETGYGLKVDIWAAGVITYILLCGFPPFRGSGDDQEVLFDQILMGQVDFPSPYWDN 615

  Fly   271 ISESAKHFIKNLMCVTVEKRYTCKQALGHAWISGNEASSRNIHGTVSEQLKKNFAKSRWKQAYYA 335
            :|:|||..|..::.|.|::|::..|.|.|.|::.:.........:|:.::||:|.......:..|
Human   616 VSDSAKELITMMLLVDVDQRFSAVQVLEHPWVNDDGLPENEHQLSVAGKIKKHFNTGPKPNSTAA 680

  Fly   336 ATVI---------RQMQRMALNSNSNANFDSS------NSSNQDSTTPTAAT 372
            ...:         ||:.|...|.:..:.:.:.      ||.::|.:..::.|
Human   681 GVSVIATTALDKERQVFRRRRNQDVRSRYKAQPAPPELNSESEDYSPSSSET 732

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CaMKI	NP_524622.1	STKc_CaMKI	27..301	CDD:270985	122/276 (44%)
CaMKI	NP_524622.1	S_TKc	31..302	CDD:214567	120/273 (44%)
DCLK1	NP_001317000.1	DCX1_DCLK1	55..143	CDD:340660
		DCX2	182..265	CDD:340589
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	287..378		0/4 (0%)
		STKc_DCKL1	383..650	CDD:271085	123/283 (43%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	697..740		6/36 (17%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG0032
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D330091at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	3	2.820