Protein Alignment CaMKI and MAPKAPK5

DIOPT Version :10

• Sequence 1: NP_524622.1
• Gene: CaMKI / 43792
• FlyBaseID: FBgn0016126
• Length: 405
• Species: Drosophila melanogaster
• Sequence 2: NP_001358408.1
• Gene: MAPKAPK5 / 8550
• HGNCID: 6889
• Length: 479
• Species: Homo sapiens
• Alignment Length: 331
• Identity: 116/331 - (35%)
• Similarity: 179/331 - (54%)
• Gaps: 59/331 - (17%)

  Fly    13 AKAKDLKELNKQVSIEEKYNLHGL--LGTGAFSEVRLAESKDSPGEHFAVKI-IDKKALKGKEES 74
            ::..|:.:..|:.||.|:|:::..  ||.|....||:...| |..|.||:|| :|:...:
Human     2 SEESDMDKAIKETSILEEYSINWTQKLGAGISGPVRVCVKK-STQERFALKILLDRPKAR----- 60

  Fly    75 LENEIRVLRRFSANHFDGKCLNGTRLTHPNIVQLLETYED----------KSKVYLVMELVTGGE 129
              ||:|              |:....|||||||::|.:.:          ::::.:|||::.|||
Human    61 --NEVR--------------LHMMCATHPNIVQIIEVFANSVQFPHESSPRARLLIVMEMMEGGE 109

  Fly   130 LFDRIVEKGSYTEKDASHLIRQILEAVDYMHEQGVVHRDLKPENLLYYSPDDDSKIMISDFGLSK 194
            ||.||.:...:|||.||.:.:||..|:.:.|...:.||||||||||:.....|:.:.:.|||.:|
Human   110 LFHRISQHRHFTEKQASQVTKQIALALRHCHLLNIAHRDLKPENLLFKDNSLDAPVKLCDFGFAK 174

  Fly   195 MEDSGIMATACGTPGYVAPEVL-AQK-----------------PYGKAVDVWSIGVISYILLCGY 241
            : |.|.:.|...||.||||:|| ||:                 .|.|:.|:||:|||.|::||||
Human   175 I-DQGDLMTPQFTPYYVAPQVLEAQRRHQKEKSGIIPTSPTPYTYNKSCDLWSLGVIIYVMLCGY 238

  Fly   242 PPFYDENDA-----NLFAQILKGDFEFDSPYWDEISESAKHFIKNLMCVTVEKRYTCKQALGHAW 301
            ||||.::.:     ::..:|:.|.|||....|.:|||.||..::.|:.|..|:|.|.:..|.|.|
Human   239 PPFYSKHHSRTIPKDMRRKIMTGSFEFPEEEWSQISEMAKDVVRKLLKVKPEERLTIEGVLDHPW 303

  Fly   302 ISGNEA 307
            ::..||
Human   304 LNSTEA 309

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CaMKI	NP_524622.1	STKc_CaMKI	27..301	CDD:270985	110/309 (36%)
MAPKAPK5	NP_001358408.1	STKc_MAPKAPK5	15..304	CDD:271073	111/311 (36%)