DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CaMKI and NNK1

DIOPT Version :9

Sequence 1:	NP_524622.1	Gene:	CaMKI / 43792	FlyBaseID:	FBgn0016126	Length:	405	Species:	Drosophila melanogaster
Sequence 2:	NP_012750.1	Gene:	NNK1 / 853683	SGDID:	S000001654	Length:	928	Species:	Saccharomyces cerevisiae

Alignment Length:	438	Identity:	98/438 - (22%)
Similarity:	167/438 - (38%)	Gaps:	90/438 - (20%)

- Green bases have known domain annotations that are detailed below.

  Fly     2 PLFGKKDSGKKAKAKDLKELNKQVSIEEKYNLHGLLGTGAFSEVRLAESKD-SPGEHFAVKIIDK 65
            ||.|......:...|.::.|.        :.|..::|.||:..:|  |..| ..|....:||:..
Yeast   428 PLSGSAGGSARPDDKGMEILG--------HRLGKIIGFGAWGIIR--ECFDIETGVGRVIKIVKF 482

  Fly    66 KALKGKEESLENEIRVLRRFSANHFDGKCLNGTRLTHPNIVQLLE-TYEDKSKVYLVMELVTGGE 129
            |..:..::.:..|:.:.|               .|.|..|:.||: ..:|...:|.:.|.:..|.
Yeast   483 KGHQNIKKHVLREVAIWR---------------TLKHNRILPLLDWKLDDNYAMYCLTERINDGT 532

  Fly   130 LFDRIVEKGSYTEKDAS------------HLIRQILEAVDYMHEQGVVHRDLKPENLLYY--SPD 180
            |:|.::   |:.|...|            .|..|:|.|:.|||.:.:||.|:|.||.|..  ...
Yeast   533 LYDLVI---SWDEFKRSKIPFAERCRLTIFLSLQLLSALKYMHSKTIVHGDIKLENCLLQKEGKK 594

  Fly   181 DDSKIMISDFGLSKMEDSGIMATACGTPGYVAPEVLAQKPYGKAVDVWSIG-------VISYILL 238
            .|.|:.:.|||:|...|.              ..|.....:.:.:   |.|       .|....|
Yeast   595 SDWKVFLCDFGMSCHFDE--------------KHVYRNDTFDENL---SSGNSHRKRKSIEQTNL 642

  Fly   239 CGYPP--FYDENDANLF--AQILKGDFE--FDSPYWDE-ISESAKHFIKNLMCVTVEKRYTCKQA 296
            ..||.  |..::..|.|  ::.||..||  ...|:..: :..|:.|.:|:|.    :...:....
Yeast   643 IKYPTTNFLPDDRTNDFDASENLKYQFENRKHQPFTPKGMVSSSSHSLKHLN----QPSSSSSSN 703

  Fly   297 LGHAWISGNEASSRN-IHG----TVSEQLKKNFAKSRWKQAYYAATVIRQMQRMALNSNSNANFD 356
            |.|...|..:...|: .||    |....|:...:|......|.:..::|........|.....:|
Yeast   704 LFHKPASQPQPQHRSPFHGRHKTTDFSNLEPEPSKYIGSLPYASPELLRYSDARRSKSVEMHIYD 768

  Fly   357 SSNSSNQDSTTPTAATGAWTSNVLSSQQSVQSHAQEMNKSGGSTNAAS 404
            |.:||..:    .:|..:.:||:.|...|.::.|  :..||.:|::.|
Yeast   769 SPDSSQSE----ISAASSSSSNLSSLSSSTKASA--VTNSGVTTSSPS 810

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CaMKI	NP_524622.1	STKc_CaMKI	27..301	CDD:270985	69/303 (23%)
CaMKI	NP_524622.1	S_TKc	31..302	CDD:214567	69/300 (23%)
NNK1	NP_012750.1	PKc	455..>613	CDD:270622	47/191 (25%)
NNK1	NP_012750.1	PKc_like	<817..864	CDD:419665
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG0032
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.900