Protein Alignment CaMKI and CAMK1

DIOPT Version :10

• Sequence 1: NP_524622.1
• Gene: CaMKI / 43792
• FlyBaseID: FBgn0016126
• Length: 405
• Species: Drosophila melanogaster
• Sequence 2: XP_005265573.1
• Gene: CAMK1 / 8536
• HGNCID: 1459
• Length: 413
• Species: Homo sapiens
• Alignment Length: 369
• Identity: 213/369 - (57%)
• Similarity: 272/369 - (73%)
• Gaps: 28/369 - (7%)

  Fly     3 LFGKKDSGKKAKAKDLKELNKQVSIEEKYNLHGLLGTGAFSEVRLAESKDSPGEHFAVKIIDKKA 67
            :.|..:..:..:|:|::::         |:...:|||||||||.|||.|.:. :..|:|.|.|:|
Human     1 MLGAVEGPRWKQAEDIRDI---------YDFRDVLGTGAFSEVILAEDKRTQ-KLVAIKCIAKEA 55

  Fly    68 LKGKEESLENEIRVLRRFSANHFDGKCLNGTRLTHPNIVQLLETYEDKSKVYLVMELVTGGELFD 132
            |:|||.|:||||.||.               ::.|||||.|.:.||....:||:|:||:||||||
Human    56 LEGKEGSMENEIAVLH---------------KIKHPNIVALDDIYESGGHLYLIMQLVSGGELFD 105

  Fly   133 RIVEKGSYTEKDASHLIRQILEAVDYMHEQGVVHRDLKPENLLYYSPDDDSKIMISDFGLSKMED 197
            ||||||.|||:|||.||.|:|:||.|:|:.|:||||||||||||||.|:||||||||||||||||
Human   106 RIVEKGFYTERDASRLIFQVLDAVKYLHDLGIVHRDLKPENLLYYSLDEDSKIMISDFGLSKMED 170

  Fly   198 SG-IMATACGTPGYVAPEVLAQKPYGKAVDVWSIGVISYILLCGYPPFYDENDANLFAQILKGDF 261
            .| :::|||||||||||||||||||.||||.||||||:||||||||||||||||.||.||||.::
Human   171 PGSVLSTACGTPGYVAPEVLAQKPYSKAVDCWSIGVIAYILLCGYPPFYDENDAKLFEQILKAEY 235

  Fly   262 EFDSPYWDEISESAKHFIKNLMCVTVEKRYTCKQALGHAWISGNEASSRNIHGTVSEQLKKNFAK 326
            ||||||||:||:|||.||::||....|||:||:|||.|.||:|:.|..:|||.:||||:||||||
Human   236 EFDSPYWDDISDSAKDFIRHLMEKDPEKRFTCEQALQHPWIAGDTALDKNIHQSVSEQIKKNFAK 300

  Fly   327 SRWKQAYYAATVIRQMQRMALNSNSNANFDSSNSSNQDSTTPTA 370
            |:||||:.|..|:|.|:::.|.::...  ....:|:.:..||.|
Human   301 SKWKQAFNATAVVRHMRKLQLGTSQEG--QGQTASHGELLTPVA 342

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CaMKI	NP_524622.1	STKc_CaMKI	27..301	CDD:270985	179/274 (65%)
CAMK1	XP_005265573.1	STKc_CaMKI_alpha	16..278	CDD:271069	181/286 (63%)