DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CaMKI and DUN1

DIOPT Version :9

Sequence 1:	NP_524622.1	Gene:	CaMKI / 43792	FlyBaseID:	FBgn0016126	Length:	405	Species:	Drosophila melanogaster
Sequence 2:	NP_010182.1	Gene:	DUN1 / 851457	SGDID:	S000002259	Length:	513	Species:	Saccharomyces cerevisiae

Alignment Length:	354	Identity:	128/354 - (36%)
Similarity:	192/354 - (54%)	Gaps:	60/354 - (16%)

- Green bases have known domain annotations that are detailed below.

  Fly     2 PLFGKKDSGKKAKAKDLKELNK--QVSIEEKYNLHGLLGTGAFSEVRLAESKDSPGEHFAVKII- 63
            |......|.....:..:::|||  .||..:||.|...||.|.::.|:.|::|.: |:..||||.
Yeast   169 PQISATSSQNATTSAAIRKLNKTRPVSFFDKYLLGKELGAGHYALVKEAKNKKT-GQQVAVKIFH 232

  Fly    64 -----DKKALKGKEESLENEIRVLRRFSANHFDGKCLNGTRLTHPNIVQLLETYED---KSKV-- 118
                 |:|    |.:....|..:|               .|:.|||||.||:::.:   ||::
Yeast   233 AQQNDDQK----KNKQFREETNIL---------------MRVQHPNIVNLLDSFVEPISKSQIQK 278

  Fly   119 YLVMELVTGGELFDRIVEKGSYTEKDASHLIRQILEAVDYMHEQGVVHRDLKPENLLY------- 176
            |||:|.:..||||:|||.|....:.::..|.:|:|..:.|:|||.::|||:||||:|.
Yeast   279 YLVLEKIDDGELFERIVRKTCLRQDESKALFKQLLTGLKYLHEQNIIHRDIKPENILLNITRREN 343

  Fly   177 --------YSPDD-DSKIMISDFGLSKMEDSGIMA---TACGTPGYVAPEVLAQKPYGKAVDVWS 229
                    :..|: |.::.|:||||:|.  :|.|.   |.||||.|||||||.:|.|...||:||
Yeast   344 PSQVQLGPWDEDEIDIQVKIADFGLAKF--TGEMQFTNTLCGTPSYVAPEVLTKKGYTSKVDLWS 406

  Fly   230 IGVISYILLCGYPPFYDE-NDANLFAQILKGDFEFDSPYWDEISESAKHFIKNLMCVTVEKRYTC 293
            .|||.|:.|||:|||.|: ...:|..|||:..:.|.|||||:|.:|..|.|.||:.:..::||..
Yeast   407 AGVILYVCLCGFPPFSDQLGPPSLKEQILQAKYAFYSPYWDKIDDSVLHLISNLLVLNPDERYNI 471

  Fly   294 KQALGHAWISGNEASSRNIHGTVSEQLKK 322
            .:||.|.|.:..:..|     :||.:|::
Yeast   472 DEALNHPWFNDIQQQS-----SVSLELQR 495

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CaMKI	NP_524622.1	STKc_CaMKI	27..301	CDD:270985	116/304 (38%)
CaMKI	NP_524622.1	S_TKc	31..302	CDD:214567	115/301 (38%)
DUN1	NP_010182.1	FHA	36..136	CDD:238017
DUN1	NP_010182.1	STKc_CAMK	199..479	CDD:270687	116/301 (39%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R2171
SonicParanoid	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.940